The efficacy and safety of long-term <i>Helicobacter</i> species quadruple therapy in asymptomatic cats with naturally acquired infection

Khoshnegah, Javad; Jamshidi, Shahram; Mohammadi, Marjan; Sasani, Farhang

doi:10.1016/j.jfms.2010.10.003

Cited by 10 publications

(9 citation statements)

References 21 publications

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“…Our results show that extending the duration of therapy can be more effective than using additional antibiotics in the therapeutic protocol such as was carried out in the study of Khoshnegah et al (2011). Although, a previous study has shown that triple therapy for seven days using clarithromycin, amoxicillin and lansoprazole was effective in 100% of dogs (Anacleto et al 2011), in human medicine, therapies of shorter duration are no longer recommended since it has been demonstrated that a 14-day triple therapy has an approximately 12% better cure rate than a 7-day therapy (Vilaichone et al 2006).…”

Section: Discussionmentioning

confidence: 67%

“…Khoshnegah et al (2011) assessed a quadruple therapy (omeprazole, amoxicillin, metronidazole and clarithromycin for 14 days) in 13 asymptomatic, naturally infected cats, but they suggested that antibiotic regimens that are effective against Helicobacter pylori in people cannot eliminate Helicobacter species in cats with naturally acquired infections (Khoshnegah et al 2011). However, our results showed the effectiveness of a 21-day threedrug regimen in dogs using omeprazole, amoxicillin and clarithromycin.…”

Section: Discussionmentioning

confidence: 73%

“…However, an optimal method has yet to be established (DeNovo and Magne 1995;Neiger and Simpson 2000;Graham et al 2003;Fischbach et al 2004;Gatta et al 2005;Gisbert et al 2005;Qasim et al 2005;Khoshnegah et al 2011;Georgopoulos et al 2012). In fact, previous studies have shown that triple or quadruple therapies are not 100% effective and, thus, further studies are needed in this regard.…”

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confidence: 99%

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Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to determine the efficacy of a triple anti-Helicobacter therapy using omeprazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation of treatment, a second molecular analysis of gastric biopsies revealed complete eradication of Helicobacter DNA with negative quantitative urease testing in all 15 dogs. Our results confirmed the high prevalence of gastric Helicobacter-like organisms (GHLOs) in the stray dog population of Shiraz, Iran, and the effectiveness of our therapeutic regimen for the complete eradication of these microorganisms in stray dogs. In conclusion, for the complete elimination of non-pylori Helicobacter spp. from the gastric mucosa of dogs, a 21-day three-drug regimen with omeprazole, amoxicillin and clarithromycin is suggested.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 73%

mentioning

confidence: 99%

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Eradication of gastric Helicobacter spp. by triple therapy in dogs

Mirzaeian¹,

Sarchahi²,

Tabrizi³

et al. 2013

Vet. Med. - Czech

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“…The hamsters (n=150) were assigned to five groups of 30 rodents each (Table 1): group 1 - uninfected controls (n=30); group 2 - hamsters treated with antibiotics (ABx) (clarithromycin 7.5 mg/kg BID+ metronidazole 20mg/kg BID + amoxicillin 20 mg/kg BID), omeprazole 0.7 mg/kg BID and sucralfate 300 mg/kg) twice a day for 14 days, as described (Khoshnegah et al, 2011); group 3 - O. viverrini infected hamsters; group 4 - O. viverrini -infected hamsters treated with ABx for 14 days; group 5 - O. viverrini -infected hamsters treated with ABx for 14 days and then treated with praziquantel (PZQ) (Biltricide, Bayer, Pittsburgh, PA) suspended in 2% Cremophor EI (Sigma, St. Louis, MO) at 400mg/kg body weight twice, with an interval of two weeks between treatments aiming to eradicate the parasites. Hamsters were euthanized, after which colorectal feces, stomach, gallbladder, liver and worms were collected from each group for DNA extraction.…”

Section: Methodsmentioning

confidence: 99%

The Carcinogenic Liver Fluke Opisthorchis viverrini is a Reservoir for Species of Helicobacter

Deenonpoe

Chomvarin²,

Pairojkul³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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There has been a strong, positive correlation between opisthorchiasis-associated cholangiocarcinoma and infection with Helicobacter. Here a rodent model of human infection with Opisthorchis viverrini was utilized to further investigate relationships of apparent co-infections with O. viverrini and H. pylori. A total of 150 hamsters were assigned to five groups: i) Control hamsters not infected with O. viverrini; ii) O. viverrini-infected hamsters; iii) non-O. viverrini infected hamsters treated with antibiotics (ABx); iv) O. viverrini-infected hamsters treated with ABx; and v) O. viverrini-infected hamsters treated both with ABx and praziquantel (PZQ). Stomach, gallbladder, liver, colonic tissue, colorectal feces and O. viverrini worms were collected and the presence of species of Helicobacter determined by PCR-based approaches. In addition, O. viverrini worms were cultured in vitro with and without ABx for four weeks, after which the presence of Helicobacter spp. was determined. In situ localization of H. pylori and Helicobacter-like species was performed using a combination of histochemistry and immunohistochemistry. The prevalence of H. pylori infection in O. viverrini-infected hamsters was significantly higher than that of O. viverrini-uninfected hamsters (p≤0.001). Interestingly, O. viverrini-infected hamsters treated with ABx and PZQ (to remove the flukes) had a significantly lower frequency of H. pylori than either O. viverrini-infected hamsters treated only with ABx or O. viverrini-infected hamsters, respectively (p≤0.001). Quantitative RT-PCR strongly confirmed the correlation between intensity H. pylori infection and the presence of liver fluke infection. In vitro, H. pylori could be detected in the O. viverrini worms cultured with ABx over four weeks. In situ localization revealed H. pylori and other Helicobacter-like bacteria in worm gut. The findings indicate that the liver fluke O. viverrini in the biliary tree of the hamsters harbors H. pylori and Helicobacter-like bacteria. Accordingly, the association between O. viverrini and H. pylori may be an obligatory mutualism.

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“…CLM has been used primarily to treat respiratory tract infections in humans and is considered to be one of the safe drugs with fewer side effects [4, 11]. In dogs, CLM can be used as one of the therapeutic options for the treatment of severe or refractory leproid granuloma [14].…”

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confidence: 99%

Preliminary Study of Effects of Multiple Oral Dosing of Clarithromycin on the Pharmacokinetics of Cyclosporine in Dogs

Katayama

Kawakami

Katayama

et al. 2014

The Journal of Veterinary Medical Science

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Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough level in human and feline organ transplant patients. However, the interaction of CLM with CsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM on the pharmacokinetics of CsA in three healthy beagles were investigated. The treatments included CsA 10 mg/kg alone and CsA 10 mg/kg + multiple-dose of CLM 10 mg/kg. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of CLM may decrease the required CsA dosage in CsA-based immunosuppressive therapy in renal transplanted dogs.

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The efficacy and safety of long-term Helicobacter species quadruple therapy in asymptomatic cats with naturally acquired infection

Cited by 10 publications

References 21 publications

Eradication of gastric Helicobacter spp. by triple therapy in dogs

Eradication of gastric Helicobacter spp. by triple therapy in dogs

The Carcinogenic Liver Fluke Opisthorchis viverrini is a Reservoir for Species of Helicobacter

Preliminary Study of Effects of Multiple Oral Dosing of Clarithromycin on the Pharmacokinetics of Cyclosporine in Dogs

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