Preliminary Study of Effects of Multiple Oral Dosing of Clarithromycin on the Pharmacokinetics of Cyclosporine in Dogs

Abstract

Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough level in human and feline organ transplant patients. However, the interaction of CLM with CsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM on the pharmacokinetics of CsA in three healthy beagles were investigated. The treatments included CsA 10 mg/kg alone and CsA 10 mg/kg + multiple-dose of CLM 10 mg/kg. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of CLM may decrease the required CsA dosage in CsA-based immunosuppressive therapy in renal transplanted dogs.

Ciclosporin 10 years on: indications and efficacy

“…In people, erythromycin has been shown to increase bioavailability of ciclosporin from 75 per cent to 215 per cent (Campana and others 1996). A similar effect has been demonstrated in the dog with clarithromycin and erythromycin, whereas clindamycin and lincomycin did not increase ciclosporin availability (Steffan 2004, Katayama and others 2013). The interaction between ciclosporin and cimetidine, an H2 receptor antagonist and a potent inhibitor of the CYP 3A system, has been studied in dogs (Daigle and others 2001).…”

The Effects of Gender and Multiple Oral Dosing on the Pharmacokinetics and Bioavailability of Morroniside in Beagle Dogs: A Pilot Study

“…Dogs were fasted for at least 12 h with free access to water prior to the pharmacokinetic studies [10][11][12][13] . Three male and three female dogs were used to determine gender-related difference of morroniside.…”