The efficacy and safety of terbinafine in children

Abstract

Terbinafine is an allylamine antifungal agent that has been effective and safe in the treatment of superficial and some deep mycotic infections in adults. An increasing amount of data is available where terbinafine has been used in the paediatric population to treat superficial fungal infections, in particular tinea capitis. The data suggest that terbinafine is effective and safe using treatment regimens that involve short duration therapy, leading to an increased compliance and providing a cost-effective means of treating paediatric superficial fungal infections such as tinea capitis. Terbinafine has been approved for the treatment of tinea capitis in many countries worldwide, and provides good efficacy rates for Trichophyton tinea capitis using shorter regimens than the gold standard griseofulvin. The adverse events profile for children is similar to that in adults with few adverse effects associated with its use. The evidence favours the use of terbinafine in the treatment of superficial infections in children.

Efficacy of Itraconazole Versus Terbinafine for the Treatment of Tineacruris.

“…Itraconazole is a wider spectrum Thiazole group of fungistati c drugs which inhibit sterol 14 α demethylase impairing biosynthesis of fungal ergosterol. Similarly Terbinafi ne is broad specturmallylamine group of fungicidal acti vity which inhibits squalene 2, 3 epoxidase enzyme thus inhibit fungal biosynsthesis of ergosterol [3][4][5] . These two drugs have been needed conventi onally as a pulse and conti nuous therapy.…”

“…This drug is lipophilic, widely distributed in the body and strongly plasma protein bound. Common side eff ect may be GIT upset and rashes 4,5 . These two drugs have been needed conventi onally as a pulse and conti nuous therapy in case of any sorts of dermatophyte infecti ons.…”

A “Solution” for Patients Unable to Swallow a Pill: Crushed Terbinafine Mixed With Syrup

“…For children, the recommended dosing of terbinafine with a 250-mg tablet is based on weight: one-quarter of a tablet for a child weighing 10 to 20 kg; one-half of a tablet for a child weighing 20 to 40 kg; and a full tablet for a child weighing more than 40 kg. 5 Because terbinafine tablets are not scored, a combined pill splitter-crusher can be used (also available at pharmacies or on Amazon; the price of this device is within the same price range as a pill crusher).…”

Neoplastische und nicht neoplastische synoviale Erkrankungen

“…DieTineac apitis wird durchI nfektion mit verschiedenenD ermatophytenh ervorgerufen (7,11) (6). Somitist derEinsatz der neueren Antimykotika, Fluconazol, Itraconazol und Te rbinafin immer ein individueller Heilversuch (Urteil derB undessozialgerichtes vom 19.…”