The efficacy and safety of Jinhua Qinggan granule (JHQG) in the treatment of coronavirus disease 2019 (COVID-19)

Abstract

Background: Currently, the global number of infected novel coronavirus has exceeded 2.6 million and the death toll has exceeded 170,000, but the specific drug for the treatment of COVID-19 has been not appears. In the process of fighting COVID-19 in China, JHQG has been promoted by the Chinese government and widely used in the treatment of COVID-19. The purpose of this study is to systematically evaluate the efficacy and safety of JHQG for COVID-19.Methods: We are going to search the electronic databases: PubMed, EMBASE, Cochrane library, Web of Science (WOS), Google scholar, China National Knowledge Infrastructure (CNKI), Chinese Biomedical literature Database (CBM), Chinese Scientific and Journal Database (VIP), Wan Fang database (Wanfang) for published clinical trails and search clinical trials register platforms of Chinese Clinical Trial Registry (ChiCTR) and ClinicalTrials.gov (www.ClinicalTrials.gov/) for ongoing trials of Jinhua Qinggan granule for COVID-19. The primary outcomes of the included studies contain Clinical symptom disappearance rate and the secondary outcomes obtain: TCM syndrome scale score, Hamilton anxiety scale score, and adverse events. We will use RevMan V5.3 software to perform the calculations. PRISMA-P checklist was used in writing this report. Results:The study results will be submitted to a peer-reviewed journal for publication. Conclusion:This study will provide a high-quality evidence of the efficacy and safety of Jinhua Qinggan granule on patients with COVID-19.

The therapeutic effects of traditional chinese medicine on COVID-19: a narrative review

“…However, clinical studies have shown that it has therapeutic efficacy against viral infections. In 2011, a clinical trial with 403 patients was conducted to verify the effectiveness of Jinhua Qinggan and oseltamivir in treating H1N1 influenza [ 11 ]. This study showed that when compared to placebo, the combination of Jinhua Qinggan and oseltamivir shortened the time patients experienced a fever ( P < 0.001), with the fever time for patients in the combination group being 19% shorter than the oseltamivir group ( P = 0.05).…”

“…Jinhua Qinggan granules Jinhua Qinggan granules are composed of honeysuckle, gypsum, ephedra (honey), bitter almond, baicalin, forsythia, fritillaria, burdock seed, artemisia annua, mint, and licorice [11]. Jinhua Qinggan has traditionally been used for the treatment of plague diseases.…”

Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining

“…In the combat against COVID-19, National Health Commission of China approved both LHQWC and JHQGG as clinical therapies in China, and observational studies showed that both can effectively relieve fever, fatigue, cough and phlegm in the early stage of COVID-19, contributing to reductions in risks of rapid clinical deterioration. Supportively, in vitro studies have revealed that both formulae have anti-inflammatory effects, providing fundamental evidence for clinical application of both formulae in the fight against COVID-19 Duan, 2020;Runfeng et al, 2020;Zhang et al, 2020).…”

Natural biflavones are potent inhibitors against SARS-CoV-2 papain-like protease

“…Of note, G. biloba , P. orientalis and L. japonica are frequently used TCMs for antiviral treatment. Remarkably, considerable research has indicated that extracts and formulas of L. japonica are effective for multiple coronaviruses including SARS-CoV-2 ( Hu et al, 2021b ; Zhang et al, 2020 ). Our findings suggested that these biflavones might act as antiviral ingredients of the above TCMs by inhibiting PL pro .…”