StatementThis prospective longitudinal study systematically described the temporal changes of CT findings in COVID-19 pneumonia and summarized the CT findings at the time of hospital discharge. Key ResultsThe extent of CT abnormalities progressed rapidly after symptom onset, peaked during illness days 6-11, and followed by persistence of high levels.The predominant pattern of abnormalities after symptom onset was ground-glass opacity; the percentage of mixed pattern peaked during illness days 12-17, and became the second most prevalent pattern thereafter.Sixty-six of the 70 patients (94%) discharged had residual disease on final CT scans, with ground-glass opacity the most common pattern. Abbreviations: COVID-19: corona virus disease 2019 SARS-CoV-2: severe acute respiratory syndrome coronavirus 2 rRT-PCR: real-time reverse transcriptase-polymerase chain reaction I n P r e s s Abstract Background: CT may play a central role in the diagnosis and management of COVID-19 pneumonia.Purpose: To perform a longitudinal study to analyze the serial CT findings over time in patients with COVID-19 pneumonia. Materials and Methods:During January 16 to February 17, 2020, 90 patients (male:female, 33:57; mean age, 45 years) with COVID-19 pneumonia were prospectively enrolled and followed up until they were discharged or died, or until the end of the study. A total of 366 CT scans were acquired and reviewed by 2 groups of radiologists for the patterns and distribution of lung abnormalities, total CT scores and number of zones involved. Those features were analyzed for temporal change.Results: CT scores and number of zones involved progressed rapidly, peaked during illness days 6-11 (median: 5 and 5), and followed by persistence of high levels. The predominant pattern of abnormalities after symptom onset was ground-glass opacity (35/78 [45%] to 49/79 [62%] in different periods). The percentage of mixed pattern peaked (30/78 [38%]) on illness days 12-17, and became the second most predominant pattern thereafter. Pure ground-glass opacity was the most prevalent sub-type of groundglass opacity after symptom onset (20/50 [40%] to 20/28 [71%]). The percentage of ground-glass opacity with irregular linear opacity peaked on illness days 6-11 (14/50 [28%)]) and became the second most prevalent subtype thereafter. The distribution of lesions was predominantly bilateral and subpleural. 66/70 (94%) patients discharged had residual disease on final CT scans (median CT scores and zones involved: 4 and 4), with ground-glass opacity (42/70 [60%]) and pure ground-glass opacity (31/42 [74%]) the most common pattern and subtype. Conclusion:The extent of lung abnormalities on CT peaked during illness days 6-11. The temporal changes of the diverse CT manifestations followed a specific pattern, which might indicate the progression and recovery of the illness.

These data suggest that a single dose of 15 microg of hemagglutinin antigen without alum adjuvant induces a typically protective immune response in the majority of subjects between 12 and 60 years of age. Lesser immune responses were seen after a single dose of vaccine in younger and older subjects. (ClinicalTrials.gov number, NCT00975572).

A novel coronavirus, designated as SARS-CoV-2, first emerged in Wuhan City, Hubei Province, China, in late December 2019. The rapidly increasing number of cases has caused worldwide panic. In this review, we describe some currently applied diagnostic approaches, as well as therapeutics and vaccines, to prevent, treat and control further outbreaks of SARS-CoV-2 infection.

Most children infected with EV71 have a good prognosis if they are diagnosed early and receive proper supportive treatment.

Background To investigate the clinical characteristics of Epstein–Barr virus (EBV) infection in the pediatric nervous system (NS). Methods We retrospectively analyzed the clinical data and follow-up results of 89 children with neurological damage caused by EBV who were hospitalized in the children’s hospital of Chongqing Medical University from January 2008 to April 2019. Results EBV infection of the NS can occur at any time of the year. The highest incidence was seen in the age group of 0–4 years. Fever is the main clinical feature (74/89, 83.1%). The main clinical types were encephalitis/meningoencephalitis (64/89, 71.9%), acute myelitis (2/89, 2.2%), acute disseminated encephalomyelitis (ADEM) (3/89, 3.4%), Guillain–Barré Syndrome (GBS) (15/89, 16.9%), neurological damage caused by EBV-hemophagocytic lymphohistiocytosis (EBV-HLH) (4/89, 4.5%), and NS-post-transplant lymphoproliferative disorder (NS-PTLD) (1/89, 1.1%). Anti-N-methyl-D-aspartate receptor encephalitis was found during the convalescence of EBV encephalitis. EBV encephalitis/meningitis showed no symptoms of tonsillitis, lymph node enlargement, skin rash, hepatosplenomegaly. Acute motor axonal neuropathy is the chief complication in GBS caused by EBV. Conclusion There were significant differences in neurological complications caused by EBV. The prognosis of EBV infection in the NS is generally good. These illnesses are often self-limiting. A few cases may show residual sequelae.

Passive seismic methods in highly populated urban areas have gained much attention from geophysics and civil engineering communities because traditional seismic surveys, especially in complex urbanized environments, might be improperly applied. In passive seismic methods, directional noise sources will inevitably bring azimuthal effects and spatial aliasing to dispersion measurements due to the fact that true randomness of ambient noise cannot be achieved in reality. To solve these problems, multichannel analysis of passive surface (MAPS) waves based on long noise sequence crosscorrelations is proposed. We have introduced a hybrid method of seismic interferometry and the roadside passive multichannel analysis of surface waves (MASW) using crosscorrelation to produce common virtual source gathers from 1 h multichannel noise records. Common virtual source gathers are then used to do dispersion analysis with an active scheme based on phase-shift measurement. Synthetic tests demonstrated the advantages of this method with azimuthal adjustment and dispersion imaging for directional noise source distribution. Two field applications were conducted, and results from the roadside passive MASW, MAPS, and spatial autocorrelation method were compared. Our study indicated the superiority of MAPS over the roadside passive MASW on the validity of azimuth detection, feasibility of combining the active MASW and MAPS, and accuracy in determining dispersion energy trends, especially at a relative low-frequency range ([Formula: see text]) in urban areas.

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