The efficacy and safety of 0.75% levobupivacaine vs 0.75% bupivacaine for peribulbar anaesthesia

Birt, David; Cummings, G.C.

doi:10.1038/sj.eye.6700313

Cited by 15 publications

(14 citation statements)

References 22 publications

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“…Similar results were reported for retrobulbar and PBs when comparing different concentrations of levobupivacaine to bupivacaine 1215. Some patients experienced mild pain during the injection of local anesthetic but trivial pain was reported at the end of the procedure and before discharge.…”

Section: Discussionsupporting

confidence: 80%

“…However, Lai et al 13. found that a mixture of bupivacaine 0.75% and lidocaine 2% provided better akinesia than a mixture of levobupivacaine 0.75% and lidocaine 2% but in our study akinesia at 10 min did not differ from previous studies that used longer needles for injection 812. Hence anterior injection of anesthetics improves safety without decreasing the block quality 14…”

Section: Discussioncontrasting

confidence: 54%

“…Birt and Cummings12 reported similar efficacy of 0.75% levobupivacaine and 0.75% bupivacaine, both mixed with hyluronidase or peribulbar anesthesia. They12 did not use the study drug in a mixture with lidocaine as we did and they used a longer needle (31 mm) with 5 ml primary volume. We rather used a relatively diluted drug concentration of 0.5% with a shorter needle (15 mm).…”

Section: Discussionmentioning

confidence: 93%

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Comparison of levobupivacaine 0.5% or bupivacaine 0.5% both in a mixture with lidocaine 2% for superficial extraconal blockade

Ahmad

Zahoor

Assiri

et al. 2012

Middle East Afr J Ophthalmol

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Purpose:To evaluate the quality and efficacy of Peribulbar blockade for superficial extraconal anesthesia with levobupivacaine 0.5% versus bupivacaine 0.5%, both combined with lidocaine 2% for patients undergoing phacoemulsification.Materials and Methods:In this prospective, double blind study, 150 patients were randomly divided into two groups: group-1 received a Peribulbar block (PB) with a mixture of evobupivacaine 0.5% and lidocaine 2% while group-2 received a PB with a mixture of bupivacaine 0.5% and lidocaine 2%. The block was performed by insertion of a short needle (15 mm) in infra-temporal space just above inferior orbital notch. An initial volume of 6 9 ml of either mixture was injected until total upper eyelid drop. Akinesia score was assessed at 2, 5, and 10 min after the block. The degree of pain was assessed by a verbal rating scale immediately after block, at the end of surgery and 4 h postoperatively. The patients and surgeons were asked to rate their satisfaction level of the quality of block postoperatively. Data were analyzed with the unpaired, two-tailed t-test and the Chi-square test as appropriate. P < 0.05 was considered statistically significant.Results:There were no significant differences between groups with respect to the akinesia score (P = 0.2) at 2, 5, and 10 min, the number of supplementary injections (P = 0.84) and initial and total required volume of local anesthetics (P = 0.80 and 0.81, respectively). There was no significant difference between the groups regarding surgeon and patient satisfaction (P = 0.53 and P = 0.74, respectively). Similarly the verbal rating scales assessed at three different occasions were not significantly different between the groups (P > 0.05 all cases). The need for additional intra-operative topical anesthetic was also similar between the groups. (P = 0.69).Conclusions:Superficial extra-conal block with a mixture of levobupivicaine 0.5% and lidocaine 2% or bupivicaine 0.5% and lidocaine 2% provides similar block quality and efficacy.

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Section: Discussionsupporting

confidence: 80%

Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 93%

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Comparison of levobupivacaine 0.5% or bupivacaine 0.5% both in a mixture with lidocaine 2% for superficial extraconal blockade

Ahmad

Zahoor

Assiri

et al. 2012

Middle East Afr J Ophthalmol

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“…In der oph thal mo lo gi schen An äs the sie wur den mit 0,75igem Le vo bu pi va cain in 3 Ar bei ten kei ne Un ter schie de zu Bu piva cain [83,84,85] oder Ro pi va cain [85] ge se hen; in ei ner Stu die wur den schlechte re Ope ra ti ons be din gun gen be ob ach tet [86]. In der Zahn-Mund-Kie fer-(ZMK-)An äs the sie zeig te Le vo bu pi va cain Vor teile ge gen über Li do cain und Pla ce bo [87] und war ver gleich bar mit Bu pi va cain [88].…”

Section: An De Re Kli Ni Sche An Wen Dun Genunclassified

Levobupivacain in der Regionalanästhesie

Urbanek

Kapral

2006

Anaesthesist

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Levobupivacaine [S(-)bupivacaine], the levorotatory S-enantiomer of racemic bupivacaine, is commercially available in the U.S. and in most European countries. We performed a systematic review (MEDLINE database) and identified 88 articles on the clinical application of levobupivacaine in more than 3,000 patients. The use of levobupivacaine is described for epidural, caudal, and spinal anesthesia, for peripheral nerve blocks, for ophthalmic and dental anesthesia, for different pediatric indications and for intravenous regional anesthesia. In these regional techniques, levobupivacaine was used for all common indications in a wide range of clinical settings. Epidural levobupivacaine was combined with fentanyl, morphine, sufentanil, epinephrine, and clonidine, spinal levobupivacaine was combined with sufentanil, fentanyl, and epinephrine. In most studies, levobupivacaine was compared to bupivacaine and/or ropivacaine.

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“…A bupivacaína tem longa duração, possui efeito anestésico e analgésico, o início de sua ação anestésica varia entre 2 a 10 minutos e seu efeito pode durar até 7 horas em alguns pacientes, o que é aproximadamente 3x mais tempo que a lidocaína. A bupivacaína racêmica tem se mostrado eficaz para o bloqueio peribulbar (4) e sua principal desvantagem está relacionada à cardiotoxicidade (5,6) . A lidocaína é um fármaco de curta ação, com iní-cio de ação em 1 a 5 minutos após infiltração e em 5 a 15 minutos para outras vias de administração.…”

Section: Introductionunclassified

Avaliação da pressão intraocular e exoftalmometria pré e pós-bloqueio peribulbar em pacientes submetidos à facectomia

Favarato¹,

Almodin²,

Almodin³

et al. 2011

Rev. bras.oftalmol.

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RESUMOObjetivos: Comparar os efeitos sobre a PIO após o bloqueio peribulbar com lidocaína e bupivacaína em pacientes submetidos à cirurgia de facectomia com implante de lente intraocular (LIO), bem como avaliar indiretamente e comparar a distribuição dos anestésicos na órbita com a medida da exoftalmometria antes e após a anestesia peribulbar. A bupivacaína e a lidocaína são anestésicos locais que rotineiramente têm sido utilizados para realização de bloqueio peribulbar. Sabe-se que a pressão intraocular (PIO) é um fator importante no pré-operatório imediato da cirurgia de catarata para evitar possíveis complicações como perda vítrea e hérnia de íris. Métodos: Cinquenta pacientes de ambos os sexos, com idade entre 48 e 93 anos, com avaliação pré-anestésica ASA I e II, foram randomizados após a conclusão da pesquisa em 2 grupos: Grupo 1: os que receberam lidocaína e Grupo 2: os que receberam bupivacaína. A medida da PIO foi realizada e analisada em 4 momentos: Antes da anestesia; 1 minuto após o bloqueio; 5 minutos após o bloqueio; 7 minutos após o bloqueio. Também foi avaliado a exoftalmometria antes e imediatamente após o bloqueio com exoftalmômetro de Luedde. Resultados: Houve um aumento na medida da PIO com o bloqueio anestésico nos dois grupos comparados, porém não houve diferença estatisticamente significante no aumento da PIO quando comparada as duas drogas analisadas. Quando comparamos a exoftalmometria, identificamos que não houve diferença estatisticamente significante no aumento da proptose em relação aos dois grupos, isto é, os dois anestésicos quando comparados distribuem-se da mesma forma na cavidade orbitária. Conclusão: Não houve diferença na variação do aumento da PIO e da na variação da exoftalmometria entre os dois anestésicos comparados.

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The efficacy and safety of 0.75% levobupivacaine vs 0.75% bupivacaine for peribulbar anaesthesia

Cited by 15 publications

References 22 publications

Comparison of levobupivacaine 0.5% or bupivacaine 0.5% both in a mixture with lidocaine 2% for superficial extraconal blockade

Comparison of levobupivacaine 0.5% or bupivacaine 0.5% both in a mixture with lidocaine 2% for superficial extraconal blockade

Levobupivacain in der Regionalanästhesie

Avaliação da pressão intraocular e exoftalmometria pré e pós-bloqueio peribulbar em pacientes submetidos à facectomia

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