The Efficacy and Safety of Topical Brinzolamide and Dorzolamide When Added to the Combination Therapy of Latanoprost and a Beta-Blocker in Patients with Glaucoma

Abstract

We concluded that the efficacy of brinzolamide 1% was equivalent to dorzolamide 1%; however, the safety of brinzolamide 1% was superior to dorzolamide 1% as adjunctive therapy to the combination with latanoprost and a beta-blocker.

24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost

“…18 IOP was maintained without further decrease when brinzolamide 1% was substituted for dorzolamide 1% in combination therapy with latanoprost and timolol. 22,23 The present study demonstrated almost identical effect on IOP reduction when the two CAIs examined were added to latanoprost.…”

“…Other researchers have reported that substituting brinzolamide 1% for dorzolamide 1% in Japanese patients with POAG maintained stable IOP while improving ocular comfort without significant increase of blurred vision. 22,23 In the domestic phase IIb study of dorzolamide, 25 no significant difference of efficacy was observed between 1% and 2% solutions whereas the latter concentration was associated with more adverse reactions. These results influenced the Japanese regulatory authority to approve dorzolamide 0.5% and 1% for clinical use.…”

The Efficacy and Ocular Discomfort of Substituting Brinzolamide for Dorzolamide in Combination Therapy with Latanoprost, Timolol, and Dorzolamide

“…4,8 Furthermore, when dorzolamide is substituted with brinzolamide, intraocular pressure (IOP) after is further decreased 5 or maintained 9,10 compared with IOP before substituting.…”

“…1 The comparative studies of dorzolamide 2% versus brinzolamide 1% 2-7 and dorzolamide 1% versus brinzolamide 1% [8][9][10] were performed to evaluate the efficacy and safety of dorzolamide and brinzolamide.…”

Comparison of twice-daily and three-times-daily dosing of dorzolamide in ocular hypertension and primary open-angle glaucoma patients treated with latanoprost

“…In a randomised, open-label comparative study in 52 glaucoma patients treated with latanoprost and a beta blocker, the mean IOP was reduced by 10% after addition of either dorzolamide or brinzolamide. 12 In a prospective, non-randomised, non-comparative trial in 14 patients with openangle glaucoma treated with latanoprost, IOP was significantly lowered (15%) at 1 month after addition of brinzolamide. 13 In a prospective, randomised trial of 22 normal tension glaucoma patients treated with latanoprost, diurnal mean IOP measurements were significantly reduced after addition of brinzolamide.…”