The Efficacy and Safety of Fentiazac and Diclofenac Sodium in Peri-Arthritis of the Shoulder: A Multi-Centre, Double-Blind Comparison

Abstract

In a double-blind parallel group comparison of efficacy and safety, 19 patients with peri-arthritis of the shoulder received 200 mg fentiazac twice daily and 19 received 50 mg diclofenac sodium twice daily, with both drugs given orally for 3 weeks. In both groups, observers' verbal rating scales of pain severity at rest and on movement showed decreases that were significant by week 1. Both groups also had significant improvement in abduction, external rotation, retroversion and anteversion. At week 1, the patients reported improvement, on a verbal rating scale, of global effectiveness, but there were no subsequent changes. There were no statistically significant differences between the treatments in any of these variables. Five (26%) fentiazac-treated patients and four (21%) diclofenac sodium-treated patients reported adverse effects, mostly gastro-intestinal. One case of rash in each group and one case of pruritus in a diclofenac sodium-treated patient were severe enough for the patients to be withdrawn from therapy. There were no clinically significant changes in laboratory values. It was concluded that fentiazac (400 mg/day) and diclofenac sodium (100 mg/day) were equally effective within 1 week in decreasing pain severity and improving shoulder mobility.

Systematic review of randomised controlled trials of interventions for painful shoulder: selection criteria, outcome assessment, and efficacy

“…Thirty one out of 58 identified studies met our selection criteria 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34. A list of excluded studies is available from us.…”

“…Reasons for exclusion were lack of randomisation (23 studies), lack of blinding (12 studies), not the study population of interest (5 studies), and not the intervention of interest (6 studies). Despite blinding, 8 of the 58 trials were identified by RB or RG, or both 4 8 14 18 20 21 25 30…”

“…The included studies assessed non-steroidal anti-inflammatory drugs (17 trials),4 5 6 7 8 10 11 12 13 16 17 18 19 22 26 29 33 intra-articular or subacromial glucocorticosteroid injection (10 trials),10 11 13 14 18 23 24 25 31 32 physiotherapy (5 trials),9 15 18 20 21 oral glucocorticosteroid treatment (2 trials),31 34 hydrodilatation (2 trials),24 32 and manipulation under anaesthesia (1 trial) 28. There were no randomised controlled trials of surgical interventions.…”

“…These included periarthritis (7 trials),4 5 16 27 29 30 31 adhesive capsulitis (6 trials),14 18 24 25 26 33 frozen shoulder (3 trials),28 29 31 rotator cuff tendinitis (7 trials),8 10 11 17 18 24 30 supraspinatus tendonitis (3 trials),29 30 32 bursitis (2 trials),8 14 infraspinatus tendonitis (1 trial),14 subscapularis tendonitis (1 trial),14 acromioclavicular joint sprain (1 trial),14 and rotator cuff lesion (1 trial) 19. Definitions of distinct diagnoses were specified in 16 of the 24 trials.…”

Pain in Rheumatoid Arthritis: Specific Features of Its Development and Methods of Correction

“…При назначении диклофенака натрия больным с хроническим артритом отмечалось значительное уменьшение выраженности артралгий, утренней скованности, припухлости суставов и болезненности при пальпации [43]. У пациентов с поражением околосуставных мягких тканей (субакромиальным бурситом, тендинитом вращательной манжетки, эпикондилитом) диклофенак натрия обеспечивал существенное снижение интенсивности болевого синдрома, а также значи-тельную положительную динамику функционального статуса [44][45][46]. В нашей стране диклофенак натрия остается одним из наиболее популярных НПВП.…”