The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis

Abstract

Objective: To assess the efficacy and safety of Curcuma longa Extract and curcumin supplements on osteoarthritis (OA). Methods: The databases such as Pubmed and Cochrane Library were searched to collect the article about Curcuma longa Extract and curcumin in the treatment of OA. Then, randomized controlled trials (RCTs) were selected and their data was extracted. Finally, the RevMan5.3 was utilized for risk of bias assessment and meta-analysis, the STATA15.0 were utilized for publication bias assessment, and GRADE tool were used for the evidence quality assessment of primary outcomes. Results: A total of 15 RCTs involving 1621 participants were included. (1) Compared with placebo, Curcuma longa Extract and curcumin (C.) can decrease the VAS and WOMAC score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, Curcuma longa Extract and curcumin are comparable to those of placebo. (2) Compared with NSAIDs, Curcuma longa Extract and curcumin have similar effects on joint pain, function and stiffness. The incidence of adverse events in Curcuma longa Extract and curcumin was lower. (3) Compared with the NSAIDs group, C.+NSAIDs can also decrease the VAS and WOMAC score-pain, the WOMAC score-function and the WOMAC score-stiffness. In terms of adverse events, the addition of Curcuma longa Extract and curcumin to NSAIDs did not increase adverse events. Conclusion: Curcuma longa Extract and curcumin may be a safer and effective supplement for OA patients. It is recommended to use Curcuma longa Extract and curcumin supplement for OA patients for more than 12 weeks.

Therapeutic Potential of Natural Products in the Treatment of Renal Cell Carcinoma: A Review

“…Antcin B, H and K (antcins) are bioactive compounds isolated from Antrodia cinnamomea , a medical mushroom widely used in Asian countries [ 82 ]. Of note, Curcuma longa extract and curcumin supplements have shown comparable relieving effects on osteoarthritis to non-steroidal anti-inflammatory drugs (NSAIDs) with less adverse effects [ 83 ]. Likewise, EGCG , another widely accepted food supplement has shown various effects in combating metabolic syndrome and cancer [ 84 ].…”

Superior Bioavailability of a Novel Curcumin Formulation in Healthy Humans Under Fasting Conditions

“…Curcumin has been extensively studied under experimental conditions as well as human clinical studies including treatment of osteoarthritis [23,[28][29][30][31], and bioavailability of curcuminoids plays an important role in the bioactivity such as exhibiting antioxidant and anti-inflammatory properties [32]. A recent study that used cell-based experimental models of osteoarthritis demonstrated that curcumin suppresses inflammation by blocking the NF-jB-Sox9 signaling pathway that plays a critical role in initiation of pathogenesis of osteoarthritis [29].…”

Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research

“…A meta-analysis showed that the use of CUR as a dietary supplement was better than glucosamine (GA) and chondroitin in improving OA in the knee joints, hip joints, and hands in the short term (Liu et al, 2018b). Other studies have also shown that CUR can reduce OA pain and improve joint function while reducing the risk of adverse events (Panahi et al, 2014;Bannuru et al, 2018;Zeng et al, 2021) and can serve to decrease the use of NSAIDs which has more adverse effects (Grover and Samson, 2016;Wang et al, 2021a). At present, there are many methods, such as nanoparticles, liposomes, micelles, and phospholipid complexes, which can extend drug release time and increase permeability and resistance to clearance (Anand et al, 2007;Wang et al, 2019).…”