The efferent connections of the nucleus raphe centralis superior in the rat as revealed by radioautography

Bobillier, Pierre; Seguin, S.; Degueurce, A.; Lewis, B.Douglas; Pujol, Jean‐François

doi:10.1016/0006-8993(79)90644-9

Cited by 139 publications

(37 citation statements)

References 15 publications

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“…It should be noted, however, that the effects obtained by dorsal raphe 5-HT injections indicated a decreased dopamine synthesis in the basal ganglia (statistically significant decrease in the olfactory tubercle and the amygdala), whereas an injection into the median raphe tended to produce the opposite result (statistically significant increase in the nucleus accumbens only). The effects of dorsal raphe 5-HT injections are in good agreement with serotonergic terminal fields as described by means of anterograde and retrograde tracer studies in the rat (Azmitia and Segal, 1978;Conrad et al, 1974;Bobillier et al, 1979;Taber Pierce et al, 1976). Thus, there was a decrease in the 5-HTP accumulation in all forebrain areas except for the hippocampus and the septum.…”

Section: Discussionsupporting

confidence: 67%

Effects of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the rat

Hillegaart

Stephan

Ahlénius

1990

J. Neural Transmission

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5-HT (10 and 40 micrograms) and 8-OH-DPAT (1 and 5 micrograms) were locally applied into the dorsal or median raphe nuclei in awake, unrestrained, rats. All animals were also treated with the 5-HTP and DOPA decarboxylase inhibitor NSD-1015, 100 mg kg-1 SC, 30 min before decapitation. 5-HT or 8-OH-DPAT were administered 5 min before NSD-1015. The regional brain in vivo rate of tyrosine and tryptophan hydroxylase activity was estimated by measuring the accumulation of DOPA and 5-HTP. The following brain regions were sampled: neocortex, hippocampus, dorso-lateral neostriatum, ventro-medial neostriatum, nucleus accumbens, olfactory tubercle, globus pallidus, septum and the amygdala. Compared to normal controls, there were small and inconsistent effects on forebrain 5-HTP accumulation by saline injections into the dorsal or the median raphe (an increase in 3 out of 36 experiments), whereas strong effects by the injection procedure were noted on forebrain DOPA accumulation (an increase in 15 out of 36 experiments). Injections of 5-HT (same effect by 10 or 40 micrograms) into the dorsal raphe, produced a decrease in 5-HTP accumulation in all forebrain areas except for the hippocampus and the septum, whereas no effects were seen in any area after median raphe injections. In contrast, 8-OH-DPAT preferentially produced a decrease in forebrain 5-HTP accumulation after median raphe injections and less, but statistically significant effects by dorsal raphe injections. The 8-OH-DPAT injection into the median raphe primarily affected limbic forebrain areas (hippocampus, nucleus accumbens, ventro-medial neostriatum, amygdala and the septum). This dissociation of the effects of 5-HT and 8-OH-DPAT on forebrain 5-HT synthesis after local application into the dorsal or the median raphe strongly supports the contention of heterogeniety in the brain 5-HT receptor population in terms of receptor subtypes and/or receptor regulation.

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Section: Discussionsupporting

confidence: 67%

Effects of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the rat

Hillegaart

Stephan

Ahlénius

1990

J. Neural Transmission

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“…However, in the context of the present work it may be relevant that, of the noradrenergic fibres which project from the locus coeruleus to the hippocampus (Pickel, Segal&Bloom, 1974;Swanson& Hartman, 1975;Jones & Moore, 1977), about half do so by the dorsal route through medial septum, fimbria and cingulum, the remainder entering by the temporal route (Storm-Mathisen & Guldberg, 1974) and that noradrenergic fibres inhibit hippocampal cells by ß-adrenergic receptors Björklund, Segal & Stenevi, 1979). Interrelationships between aminergic fibre systems in this region are complex since the dorsal noradrenergic input to the hippocampus is accompanied by the majority of serotonergic fibres which project from the median raphe to the hippocampus (Lorens & Guldberg, 1974;Storm-Mathisen & Guldberg, 1974;Moore & Halaris, 1975; Bobillier, Seguin, Deguerce, Lewis & Pujol, 1979) which counter the effect of the pacemaker by inhibiting the theta rhythm (Maru, Takahashi & Iwahara, 1979). In turn, noradrenergic fibres from the locus coeruleus can inhibit the median raphe (Massari, Tizabi & Jacobowitz, 1979).…”

Section: Discussionmentioning

confidence: 96%

A Neural Basis for Central Inhibition of Milk Ejection in the Rabbit

Tindal¹,

Blake²

1980

Journal of Endocrinology

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Discrete, transverse stereotaxic cuts in th forebrain of the anesthetized lactating rabbit caused spontaneous milk-ejection responses repeated at intervals of 1-5 min. The region of the brain in which cuts were effective included the diagonal band of Broca, the entire rostrocaudal extent of the dorsal medial septum, part of the cingulum and part of the hippocampal fimbria. It is proposed that severance of a septo-hippocampal patway frees the hippocampus from inhibition and allows oxytocin release to occur. It remains to be determined whether the hippocampus itself is directly responsible for periodic activation of neurosecretory cells.

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“…In addition, the vast majority of other projections to LA originate in forebrain areas Herzog and Van Hoesen, 1975;Jones and Powell, 1970;Price et al, 1987;Russchen, 1982;Turner et al, 1980), and damage to the caudal diencephalon leaves these connections intact. The only regions caudal to MGm/PIN that give rise to a significant projection to LA are the midline raphe groups (Bobillier et al, 1979;Kheck, et al, 1991;Moore et al, 1978;Parent et al, 1981), the fibers of which are unlikely to pass laterally through the lesioned area.…”

Section: Methodological Considerations Degeneration As An Anterogradementioning

confidence: 97%

NMDA and AMPA receptors in the lateral nucleus of the amygdala are postsynaptic to auditory thalamic afferents

Farb

LeDoux

1997

Synapse

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Projections from the medial geniculate body (MGB) to the lateral nucleus of the amygdala (LA) have been implicated in the conditioning of emotional reactions to acoustic stimuli. Anatomical and physiological studies indicate that this pathway uses the excitatory amino acid L-glutamate as a transmitter. Recent physiological studies have demonstrated that synaptic transmission in the thalamo-amygdala pathway requires the activation of both N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors, two of the major classes of ionotrophic glutamate receptors. In order to characterize the nature of thalamoamygdala interactions, we examined the synaptic associations between thalamic afferents and amygdala neurons that contain at least one glutamate receptor subtype. Thalamic afferents to the amygdala were identified by lesion-induced anterograde degeneration and anterograde transport of biotinylated dextran-amine, while postsynaptic glutamate receptors were labeled immunocytochemically using antisera directed the R1 subunit of the NMDA receptor and the GluR1 and GluR2/3 subunits of the AMPA receptors. Both methods demonstrated that the majority (77%) of thalamic afferents contact dendritic spines, and most (60%) of these spines express at least one glutamate receptor subtype. To a lesser extent, identified afferents also contacted small and large dendritic shafts, and many of these were immunoreactive. Thalamic afferents terminated on approximately the same proportion (60%) of immunoreactive targets for each glutamate receptor studied. These data provide morphological evidence that thalamic afferents directly synapse onto amygdala neurons that express glutamate receptors and suggest ways in which thalamic afferents activate and influence amygdala circuitry.

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The efferent connections of the nucleus raphe centralis superior in the rat as revealed by radioautography

Cited by 139 publications

References 15 publications

Effects of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the rat

Effects of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the rat

A Neural Basis for Central Inhibition of Milk Ejection in the Rabbit

NMDA and AMPA receptors in the lateral nucleus of the amygdala are postsynaptic to auditory thalamic afferents

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