There is no evidence that ultrasound examination during pregnancy is harmful. Prenatal exposure to ultrasound is not associated with adverse influence on school performance and physical or neurological function. l Ultrasound should be performed by trained and experienced professionals, with continuing education and ongoing quality-monitoring programs. l Routine use of ultrasound increases early detection of multiple pregnancies, increases earlier detection of major fetal anomalies when termination of pregnancy is possible, and increases detection rates of fetal malformations. l Ultrasound examination is the best method to estimate gestational age dating in pregnancy.l Ultrasound examination at first prenatal visit (usually first trimester) versus at 18 to 20 weeks provides more precise estimate of gestational age and may be associated with less women feeling worried about their pregnancy. First-trimester ultrasound also allows earlier detection of multiple pregnancies, screening for Down's syndrome with nuchal translucency (NT), and diagnosis of nonviable pregnancies. l All pregnant women should be offered a second-trimester ultrasound for optimal anatomy evaluation. Until more evidence accumulates regarding the detection of fetal anomalies on the first-trimester ultrasound, if only one ultrasound will be done in pregnancy, it should be a second-trimester scan at about 18 to 22 weeks. l In low-risk or unselected populations, routine third-trimester (>24 weeks) pregnancy ultrasound has not been associated with improvements in perinatal mortality, though these studies lack sufficient sample size. Routine use of ultrasound in the third trimester significantly decreases the rate of intrauterine growth restriction (IUGR). l Routine use of ultrasound reduces the incidence of postterm pregnancies and rates of induction of labor for postterm pregnancy. l In low-risk or unselected populations, routine Doppler ultrasound examination, usually around 28 to 34 weeks, does not result in reduced perinatal mortality. l In high-risk populations, such as those with IUGR, umbilical artery Doppler assessment is associated with a reduction in perinatal deaths and obstetric interventions.l Measurement of cervical length (CL) by transvaginal ultrasound (TVU) has been shown to be an effective predictor of preterm birth (PTB). When a short CL is detected before 24 weeks, interventions such as vaginal progesterone in singletons without prior PTB (using TVU CL < 21 mm) and cerclage in singletons with prior PTB (using TVU CL < 25 mm) have been associated with decrease in PTB and perinatal morbidity and mortality.