The effects on bone cells of metal ions released from orthopaedic implants. A review

Abstract

SummaryThe increasing use of orthopedic implants and, in particular, of hip and knee joint replacements for young and active patients, has stimulated interest and concern regarding the chronic, long-term effects of the materials used. This review focuses on the current knowledge of the adverse biologic reactions to metal particles released from orthopaedic implants in vivo and in vitro. More specifically, the purpose of this article is to provide an overview of the current literature about the adverse effects of metal particles on bone cells and peri-implant bone.

Tribocorrosion behavior of veneering biomedical PEEK to Ti6Al4V structures

“…A major concern regarding the toxicity of the wear particles released into the human body during the performance of the orthopedic implants has been reported in the literature (Souza et al, 2015;Guleryuz and Cimenoglu, 2004;Sansone et al, 2013;Maloney et al, 1993;Kumazawa et al, 2002;Case et al, 1994;Urban et al, 2000;Goodman, 2007;Hallab et al, 2000;Ozakaki, 2001). Wear debris and ions release produced due to the loss of material by bio-tribocorrosion of titanium-based prosthetic surfaces have been related to tissue inflammatory reactions (Souza et al, 2015;Guleryuz and Cimenoglu, 2004;Sansone et al, 2013;Maloney et al, 1993;Kumazawa et al, 2002;Case et al, 1994;Urban et al, 2000;Goodman, 2007;Hallab et al, 2000;Ozakaki, 2001). The presence of metallic ions and particles in human tissues induces the activation of macrophages, neutrophils, and T-lymphocytes with elevation of cytokines and metallic proteinases that can promote bone resorption (Maloney et al, 1993;Kumazawa et al, 2002).…”

Nanotoxicity: emerging concerns regarding nanomaterial safety and occupational hard metal (WC-Co) nanoparticle exposure

“…22 Additionally, emerging evidence suggests that humans may also be exposed to NPs internally, which may be generated in situ due to orthopedic surgical implant wear. 23,24 These potential routes of NP exposure are summarized graphically in Figure 1. Importantly, the route of exposure ultimately determines which body system or specific tissues the NPs interact with which in turn determines the effects of NP exposure such as toxicity 25,26 or alterations in physiological function.…”

Implantação de Íons de Nitrogênio em PMMA Através de uma Fonte Kaufman

“…Estudos prévios comprovam que o cromo é citotóxico a diversos tipos de célula, em especial osteoblastos, cuja viabilidade e proliferação são afetadas e, consequentemente, a osseointegração torna-se um problema [34][35][36]. Íons de ferro também mostram toxicidade, quando em forma de detritos em implantes ósseos [37]. A presença do ferro e do cromo foi comprovada via análise por Espectroscopia por Dispersão em Energia (EDS).…”