The effects of Vitis vinifera L. phenolic compounds on a blood-brain barrier culture model: Expression of leptin receptors and protection against cytokine-induced damage

Ardid-Ruiz, Andrea; Harazin, András; Barna, Lilla; Walter, Fruzsina R.; Bladé, Cinta; Suárez, Manuel; Deli, Mária A.; Aragonès, Gerard

doi:10.1016/j.jep.2019.112253

Cited by 27 publications

(21 citation statements)

References 75 publications

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“…Studies have addressed that bioactive compounds present in food can improve leptin resistance by acting in the recovery of signaling between leptin and neurotransmitters and in the transport of this adipokine to the blood-brain barrier [ 64 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Resistance Training Associated with Dietetic Advice Reduces Inflammatory Biomarkers in the Elderly

Lopes

Oliveira

Becker

et al. 2020

BioMed Research International

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Aging is a biological process during which chronic low-grade inflammation is present due to changes in the immune system of the elderly. The main objective of this study is to evaluate the effects of resistance training associated with dietary advice on chronic inflammation in the elderly. We conducted a prospective intervention study in which we evaluated anthropometric parameters and inflammatory biomarkers (CRP, IL-8, CCL-2, and leptin) in 40 elderly people before and after long-term progressive resistance training (19 weeks) associated with dietary advice. The participants trained twice a week on nonconsecutive days, and the training lasted one hour with an intensity of 60-85% of 1-MR. Dietary advice was explained in person and individually focusing on foods rich in compounds with anti-inflammatory and antioxidant properties. Participants were instructed at the beginning of the training program, and dietary advice was reinforced verbally weekly. There was an improvement in body composition evidenced by a reduction in waist circumference and body fat percentage and by the increase in arm circumference, calf circumference, and corrected arm muscle area. In addition, there was a reduction in the inflammatory biomarkers CCL-2 (p=0.01) and leptin (p<0.01). Resistance training associated with dietary guidance can contribute to a healthy aging due to observed improvements in body composition and in the inflammatory profile of the elderly.

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Section: Discussionmentioning

confidence: 99%

Resistance Training Associated with Dietetic Advice Reduces Inflammatory Biomarkers in the Elderly

Lopes

Oliveira

Becker

et al. 2020

BioMed Research International

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“…Increase in pro-inflammatory cytokines such as TNF-α, interleukin-1β, and interleukin-6 are frequently observed in infants suffering from neonatal sepsis. [ 23 ] These events might damage the endothelial integrity and increase blood brain barrier permeability, [ 24 , 25 ] which could facilitate the entry of free bilirubin to the brain. This may be 1 possible explanation of the association between sepsis and ABE.…”

Section: Discussionmentioning

confidence: 99%

A clinical prediction rule for acute bilirubin encephalopathy in neonates with extreme hyperbilirubinemia

Zhang¹,

Chen²,

Shang

et al. 2020

Medicine

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To establish a clinical prediction rule for acute bilirubin encephalopathy (ABE) in term/near-term neonates with extreme hyperbilirubinemia. A retrospective cohort study was conducted between January 2015 and December 2018. Six hundred seventy-three out of 26,369 consecutive neonates with extreme hyperbilirubinemia were enrolled in this study. Data included demographic characteristics, total serum bilirubin (TSB), albumin, bilirubin/albumin ratio (B/A), direct antiglobulin test, glucose-6-phosphate deficiency, asphyxia, sepsis, acidosis. ABE was defined as a bilirubin induced neurological dysfunction score of 4 to 9. We used stepwise logistic regression to select predictors of ABE and devised a prediction score. Of the 673 eligible infants, 10.8% suffered from ABE. Our prediction score consisted of 3 variables: TSB (as a continuous variable; odds ratio [OR] 1.16; 95% confidence interval [CI], 1.02–1.31; logistic coefficient 0.15), B/A (as a continuous variable; OR 1.88; 95% CI, 1.19–2.97; logistic coefficient 0.67), and sepsis (OR 3.78; 95% CI, 1.40–10.21; logistic coefficient 1.19). Multiplying the logistic coefficients by 10 and subtracting 75, resulted in the following equation for the score: Score = 12 × (if sepsis) + 1.5 × (TSB) + 7 × (B/A) − 75. The model performed well with an area under the curve of 0.871. The risk of ABE can be quantified according to TSB, B/A, and sepsis in term/near-term neonates with extreme hyperbilirubinemia.

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“…Thus, the enhanced OBRb protein content induced by RSV reported for the first time in the present study could be the mechanism by which this compound increased the cellular response to leptin in our experimental model of hepatic fat accumulation. In fact, we have demonstrated in previous studies that cafeteria-fed rats supplemented with a high dose of RSV show an increase in OBRb protein concentrations in skeletal muscle [7] and in rat brain endothelial cells [26], but it has never been reported in the liver. In the present study, the effects of RSV on the cellular content of OBRb assessed by Western blotting and immunofluorescence suggest that RSV re-established the leptin sensibility of steatotic hepatocytes by increasing the cell surface content of ObRb to enhance the cellular response to leptin.…”

Section: Discussionmentioning

confidence: 84%

Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells

Ardid-Ruiz

Ibars

Mena

et al. 2019

IJMS

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The interaction of leptin with its hepatic longest receptor (OBRb) promotes the phosphorylation of signal transducer and activator of transcription-3 (STAT3), protecting the liver from lipid accumulation. However, leptin signalling is disrupted in hepatic steatosis, causing leptin resistance. One promising strategy to combat this problem is the use of bioactive compounds such as polyphenols. Since resveratrol (RSV) is a modulator of lipid homeostasis in the liver, we investigated whether treatment with different doses of RSV restores appropriate leptin action and fat accumulation in palmitate-induced steatotic human hepatoma (HepG2) cells. Both RSV metabolism and the expression of molecules implicated in leptin signalling were analysed. RSV at a 10 μM concentration was entirely metabolized to resveratrol-3-sulfate after 24 and counteracted leptin resistance by increasing the protein levels of OBRb. In addition, RSV downregulated the expression of lipogenic genes including fatty acid synthase (Fas) and stearoyl-CoA desaturase-1 (Scd1) without any significant change in Sirtuin-1 (SIRT1) enzymatic activity. These results demonstrate that RSV restored leptin sensitivity in a cellular model of hepatic steatosis in a SIRT1-independent manner.

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The effects of Vitis vinifera L. phenolic compounds on a blood-brain barrier culture model: Expression of leptin receptors and protection against cytokine-induced damage

Cited by 27 publications

References 75 publications

Resistance Training Associated with Dietetic Advice Reduces Inflammatory Biomarkers in the Elderly

Resistance Training Associated with Dietetic Advice Reduces Inflammatory Biomarkers in the Elderly

A clinical prediction rule for acute bilirubin encephalopathy in neonates with extreme hyperbilirubinemia

Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells

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