The Effects of Vitamin D Application on NaF-Induced Cytotoxicity in Osteoblast Cells (hFOB 1.19)

Dede, Semiha; Taşpınar, Mehmet; Yüksek, Veysel; Çetin, Sedat; Usta, Ayşe

doi:10.1007/s12011-022-03177-8

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…More precisely, several enzymes require divalent metal ions as cofactors such as magnesium, calcium, zinc and selenium which have a strong affinity with fluoride, and thus can induce oxidative stress resulting from an inhibitory interaction of these enzymes 13 , 48 , 49 . For that, recent studies focused on supplementation of animals with antioxidants such as gallic acid 50 , quercetin 51 , vitamins 7 , 46 , 52 and medicinal plants 6 , 19 , 26 . In this study, Spirulina platensis showed an ameliorative effect against oxidative stress in fluorotic sheep species.…”

Section: Discussionmentioning

confidence: 99%

“…However, chronic exposure to high fluoride level can lead to several chronic intoxications such as dental and skeletal fluorosis 5 . Another important aspect of fluoride toxicity is its impact on the antioxidant system 6 and generation of free radicals 7 . Fluorosis is a global health problem and it is endemic in different parts of the world 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

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An interventional clinical trial investigating the effects of Spirulina platensis on dental fluorosis and antioxidant system in lambs reared in endemic areas

Rahim,

Sibaoueih,

Essamadi

et al. 2023

Sci Rep

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This study aimed to evaluate the protective effect of Spirulina platensis primary against dental fluorosis and secondary against oxidative stress in lambs reared in endemic fluorosis areas. Forty-eight lambs aged 5 months were divided into four equal groups (each one including 6 males and 6 females). Groups I and II served as controls belonging respectively to fluorosis-free (Settat) and endemic fluorosis (El Fokra) areas, while the other two Groups III and IV (belonging to El Fokra) received respectively a fixed daily intake of 250 and 500 mg/kg bodyweight (BW) of Spirulina platensis. The experiment was carried out for 13 months until the adult incisors appeared for all animals. According to the Dean’s Fluorosis Index (DFI), 500 mg/kg BW/day of Spirulina platensis (Group IV) protected against dental fluorosis. Moreover, in both male and female lambs, this dose significantly (p < 0.0001) reduced the plasmatic levels of fluoride, proteins, GSH, and MDA compared to the Group II. Furthermore, enzymatic activities of catalase and SOD increased significantly (p < 0.0001) in male and female lambs of the Group IV as compared to Group II. In conclusion, our findings support the potential use of Spirulina platensis as a valuable solution for addressing fluorosis in sheep, warranting further clinical trials.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An interventional clinical trial investigating the effects of Spirulina platensis on dental fluorosis and antioxidant system in lambs reared in endemic areas

Rahim,

Sibaoueih,

Essamadi

et al. 2023

Sci Rep

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“…Vitamin D deficiency [ 255 ] or Ca excess [ 256 ] were shown to aggravate F-induced alterations in bone metabolism. Correspondingly, vitamin D treatment significantly reduced F-induced osteoblast apoptosis [ 257 ].…”

Section: Fluoride (F)mentioning

confidence: 99%

The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings

et al. 2023

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The objective of the present study was to review recent epidemiological and clinical data on the association between selected minerals and trace elements and osteoporosis, as well as to discuss the molecular mechanisms underlying these associations. We have performed a search in the PubMed-Medline and Google Scholar databases using the MeSH terms “osteoporosis”, “osteogenesis”, “osteoblast”, “osteoclast”, and “osteocyte” in association with the names of particular trace elements and minerals through 21 March 2023. The data demonstrate that physiological and nutritional levels of trace elements and minerals promote osteogenic differentiation through the up-regulation of BMP-2 and Wnt/β-catenin signaling, as well as other pathways. miRNA and epigenetic effects were also involved in the regulation of the osteogenic effects of trace minerals. The antiresorptive effect of trace elements and minerals was associated with the inhibition of osteoclastogenesis. At the same time, the effect of trace elements and minerals on bone health appeared to be dose-dependent with low doses promoting an osteogenic effect, whereas high doses exerted opposite effects which promoted bone resorption and impaired bone formation. Concomitant with the results of the laboratory studies, several clinical trials and epidemiological studies demonstrated that supplementation with Zn, Mg, F, and Sr may improve bone quality, thus inducing antiosteoporotic effects.

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“…This term was coined by Norman’s laboratory to describe the rapid onset of calcium flow through the intestine of a Vit-D-fortified chick fed with 1,25(OH) 2 D [ 53 ]. Moreover, Vit D has been shown to modulate not only calcium, but also chloride channel activity, protein kinase C activation and distribution, and phospholipase C activity in various types of cell, including osteoblast, liver, muscle, and intestinal cells [ 54 , 55 , 56 , 57 , 58 ]. Vit D can also stimulate phosphate reabsorption in renal tubules and trigger the secretion of calcium from the bones into the blood.…”

Section: Overall Effects Of Vitamin D: From Antioxidant To Genomic Ef...mentioning

confidence: 99%

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

et al. 2022

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Background: Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent. Methods: A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health. Results: In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases. Conclusions: Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.

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The Effects of Vitamin D Application on NaF-Induced Cytotoxicity in Osteoblast Cells (hFOB 1.19)

Cited by 5 publications

References 31 publications

An interventional clinical trial investigating the effects of Spirulina platensis on dental fluorosis and antioxidant system in lambs reared in endemic areas

An interventional clinical trial investigating the effects of Spirulina platensis on dental fluorosis and antioxidant system in lambs reared in endemic areas

The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

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