The Effects of Vasoactive Intestinal Peptide on Dura Mater Nitric Oxide Levels and Vessel-Contraction Responses in Sympathectomized Rats

Töre, Fatma; Korkmaz, Orhan Tansel; Doğrukol-Ak, Dilek; Tunçel, Neşe

doi:10.1007/s12031-009-9310-8

Cited by 9 publications

(10 citation statements)

References 37 publications

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“…Our results show that short-term sympathectomy induces activation of ipsilateral trigeminal neurons and increases the number of mast cells in the dura mater. Previously it was shown that sympathectomy also increased dura mater NO levels (Tore et al, 2010).…”

Section: Discussionmentioning

confidence: 97%

“…In a previous study, VIP modulated hypotension in sepsis, prolonging survival time (Tunçel and Tore, ). Systemic administration of VIP in sympathectomized rats increased aortic contraction responses and decreased dura mater NO levels to control levels (Tore et al, ). VIP also promotes the survival of sympathetic neuroblasts, enhances differentiation, and regulates neural tube closure during embryogenesis (Pincus et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Check et al () showed that sympathetic amines treated resistant headaches in women. Although contradictory studies exist, it has been shown that short‐term sympathectomy induces a significant increase in dura mater NO levels and that VIP modulates NO to control these levels (Tore et al, ). The present study investigates the effects of VIP on the number of mast cells in the dura mater and on c‐Fos expression in the trigeminal nucleus of sympathectomized rats.…”

mentioning

confidence: 99%

“…VIP is a major neuropeptide neurotransmitter with neurotrophic, neuromodulatory, antioxidant, anti-inflammatory, and antiapoptotic properties (Said and Dickman, 2000;Dogrukol-Ak et al, 2004;Arranz et al, 2008a,b;Tan and Waschek, 2011). In a previous study, systemic administration of VIP in sympathectomized rats increased aortic contraction responses and decreased dura mater nitric oxide (NO) to control levels (Tore et al, 2010).…”

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confidence: 99%

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Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

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Fırat

Töre

et al. 2014

Journal of Neuroscience Research

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Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c-Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague-Dawley male rats with body weights of 200-250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c-Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P < 0.001). VIP decreased the number of mast cells in both sides of the dura mater in sympathectomized rats. VIP also decreased c-Fos expression in the ipsilateral trigeminal nucleus of sympathectomized rats (P < 0.001). In the context of an experimental superior cervical ganglionectomy model of migraine, VIP is an efficient modulator of neurogenic inflammation of the dura.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

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Fırat

Töre

et al. 2014

Journal of Neuroscience Research

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“…The sympathetic nervous system inhibits the trigeminal system (Peroutka, 2004). Superior cervical ganglionectomy increased dura mater NO levels, c-fos expression in the spinal trigeminal nucleus caudalis (TNc) and induced degranulation of meningeal mast cells (Tore et al, 2010; Kilinc et al, 2015). Yildiz et al (2007) measured a facial sympathetic skin response that indicated the activation of the sympathetic nervous system.…”

Section: From Functional Cross-talk Toward Therapeutical Targetmentioning

confidence: 99%

Shared Fate of Meningeal Mast Cells and Sensory Neurons in Migraine

Irmak

Kılınç

Töre

2019

Front. Cell. Neurosci.

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Migraine is a primary headache disorder which has complex neurogenic pathophysiological mechanisms still requiring full elucidation. The sensory nerves and meningeal mast cell couplings in the migraine target tissue are very effective interfaces between the central nervous system and the immune system. These couplings fall into three categories: intimacy, cross-talk and a shared fate. Acting as the immediate call-center of the neuroimmune system, mast cells play fundamental roles in migraine pathophysiology. Considerable evidence shows that neuroinflammation in the meninges is the key element resulting in the sensitization of trigeminal nociceptors. The successive events such as neuropeptide release, vasodilation, plasma protein extravasation, and mast cell degranulation that form the basic characteristics of the inflammation are believed to occur in this persistent pain state. In this regard, mast cells and sensory neurons represent both the target and source of the neuropeptides that play autocrine, paracrine, and neuro-endocrine roles during this inflammatory process. This review intends to contribute to a better understanding of the meningeal mast cell and sensory neuron bi-directional interactions from molecular, cellular, functional points of view. Considering the fact that mast cells play a sine qua non role in expanding the opportunities for targeted new migraine therapies, it is of crucial importance to explore these multi-faceted interactions.

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