Cervical sympathectomy reduces neurogenic vasodilation in dura mater of rats

Wei, Jun-chao; Yan, Lanyun; Liu, Ting; Xu, Wu; Shi, Zhang; Wu, Ting; Wan, Qi

doi:10.1016/j.autneu.2011.01.005

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…That any effect would last for 12 days in the sham groups was unexpected. We acknowledge the possibility of other compensatory effects due to SCGx, although we (Figure 1b) and others (48) have not detected any surgery-induced changes in calcitonin gene-related peptide IHC. While the relative impact of SPGN innervation on stress-induced changes in dural immune cells was confounded by the influence of surgery, per se, there were still cases of marked differences between SCGx and sham surgery groups, implicating a role of SPGN in the regulation of dural immune cells.…”

Section: Discussionmentioning

confidence: 47%

Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura

et al. 2016

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Aim of investigation Due to compelling evidence in support of links between sex, stress, sympathetic post-ganglionic innervation, dural immune cells, and migraine, our aim was to characterize the impacts of these factors on the type and proportion of immune cells in the dura. Methods Dural immune cells were obtained from naïve or stressed adult male and female Sprague Dawley rats for flow cytometry. Rats with surgical denervation of sympathetic post-ganglionic neurons of the dura were also studied. Results Immune cells comprise ~17% of all cells in the dura. These included: macrophages/granulocytes (“Macs”; 63.2% of immune cells), dendritic cells (0.88%), T-cells (4.51%), natural killer T-cells (0.51%), natural killer cells (3.08%), and B-cells (20.0%). There were significantly more Macs and fewer B- and natural killer T-cells in the dura of females compared with males. Macs and dendritic cells were significantly increased by stress in males, but not females. In contrast, T-cells were significantly increased in females with a 24-hour delay following stress. Lastly, Macs, dendritic cells, and T-cells were significantly higher in sympathectomized-naïve males, but not females. Conclusions It may not only be possible, but necessary to use different strategies for the most effective treatment of migraine in men and women.

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Section: Discussionmentioning

confidence: 47%

Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura

et al. 2016

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“…However, these results have been contradicted by another experimental study. Wei et al () showed that jugular venous blood CGRP levels and dural blood flow did not change 12 days after unilateral sympathectomy of female rats. They could not detect any blood flow change despite increased CGRP levels after trigeminal stimulation in sympathectomized rats.…”

Section: Discussionmentioning

confidence: 99%

Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

Kılınç

Fırat

Töre

et al. 2014

Journal of Neuroscience Research

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Neurogenic inflammation in the dura mater caused by trigeminal nociceptive activation has been implicated in the pathophysiology of migraine. Vasoactive intestinal polypeptide (VIP) is a powerful neuroprotective neuropeptide that can modulate mast cell behavior. Migraine is also associated with sympathetic insufficiency. This study investigates the effects of VIP on the number of mast cells in the dura mater and on c-Fos expression in the trigeminal nucleus of sympathectomized rats. Experiments were carried out with 32 Sprague-Dawley male rats with body weights of 200-250 g. In the sympathectomized group, the left superior cervical sympathetic ganglion was removed. In the sympathectomized + VIP group, postoperative VIP 25 ng/kg/day (0.2 ml) was administered for 5 days. In the sham group, the ganglion and nerves were exposed but not dissected. Dura maters were stained with toluidine blue, and brainstems were labeled by indirect immunohistochemistry for c-Fos. Sympathectomy significantly increased the number of mast cells in both the ipsilateral and the contralateral dura mater (P < 0.001). VIP decreased the number of mast cells in both sides of the dura mater in sympathectomized rats. VIP also decreased c-Fos expression in the ipsilateral trigeminal nucleus of sympathectomized rats (P < 0.001). In the context of an experimental superior cervical ganglionectomy model of migraine, VIP is an efficient modulator of neurogenic inflammation of the dura.

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“…Nevertheless, cervical sympathetic nerves have been shown to play an important role in the process of neurogenic dural vasodilation in rats [11]. In addition, a recent functional neuroimaging study identified potential important alterations in the hypothalamic connectivity across the migraine phases [12], in agreement with a pivotal role of the hypothalamus in the regulation of migraine-related head pain [13].…”

Section: Introductionmentioning

confidence: 79%

Effectiveness of Novel Sympathetic Nerve Entrapment Point Injections for Chronic Migraine: A Pilot Study

Seong,

Kim,

Kwon

et al. 2023

Life

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No studies to date have investigated the ability of sympathetic nerve entrapment point saline (SNEP) injections to achieve long-term pain relief in patients with migraine. Therefore, this study aimed to investigate the safety and long-term efficacy of repeat splenius capitis (SC) SNEP injections in patients with migraine (with/without tension-type headache). This retrospective, single-arm study included 12 patients with migraine. Isotonic saline was injected into their SC approximately six times for 3 months. Headache frequency, duration (hour/week), intensity (using the visual analog scale), and quality of life (using the Headache Impact Test-6) were assessed during the follow-up visits for up to 24 months after the first injection. Changes before and after treatment were assessed using repeated-measures analysis of variance. Significant reductions in headache frequency, duration, and intensity were observed at all assessment points after SNEP injections when compared with the baseline values (p < 0.05), while the patients’ headache-related quality of life also improved. Treatment was continued for up to 3 months to maintain these improvements, and no worsening of status or adverse effects were observed in any of the patients over the following 24 months. Our results show that SNEP injections may offer persistent, substantial, and clinically relevant benefits in patients with migraine.

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Cervical sympathectomy reduces neurogenic vasodilation in dura mater of rats

Cited by 7 publications

References 25 publications

Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura

Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura

Vasoactive Intestinal peptide modulates c-Fos activity in the trigeminal nucleus and dura mater mast cells in sympathectomized rats

Effectiveness of Novel Sympathetic Nerve Entrapment Point Injections for Chronic Migraine: A Pilot Study

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