The effects of treatment with drospirenone/ethinyl oestradiol alone or in combination with metformin on elastic properties of aorta in women with polycystic ovary syndrome

Kaya, Mehmet; Çalapkorur, Bekir; Karaca, Züleyha; Yıldırım, Sümeyra; Çelik, Ahmet; Akpek, Mahmut; Ünlühızarcı, Kürşad; Keleştimur, Fahrettin

doi:10.1111/j.1365-2265.2012.04436.x

Cited by 15 publications

(11 citation statements)

References 42 publications

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“…In treatment of patients with PCOS, it should be considered that they have an increased cardiovascular risk profile. Treatment options, which improve cardiovascular risk factors, should be preferred if they have similar effects on hormonal parameters [24]. In this study, however, we showed OCP and metformin plus OCP treatment arms have similar effects on hormonal parameters, metformin plus OCP arm has positive effects on BMI, insulin resistance.…”

Section: Discussioncontrasting

confidence: 74%

Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

Kaya¹,

Yıldırım

Çalapkorur³

et al. 2015

Gynecological Endocrinology

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Section: Discussioncontrasting

confidence: 74%

Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

Kaya¹,

Yıldırım

Çalapkorur³

et al. 2015

Gynecological Endocrinology

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“…Treatment with pioglitazone and rosiglitazone was associated with improvement in adiponectin levels [66]. Besides glitazones, metformin was also shown to reduce arterial stiffness in several studies, including women with polycystic ovary syndrome [88, 89]. …”

Section: Influence Of Drugs On Arterial Stiffnessmentioning

confidence: 99%

Arterial Stiffness and Cardiovascular Therapy

Janić

Lunder

Šabovič

2014

BioMed Research International

120

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The world population is aging and the number of old people is continuously increasing. Arterial structure and function change with age, progressively leading to arterial stiffening. Arterial stiffness is best characterized by measurement of pulse wave velocity (PWV), which is its surrogate marker. It has been shown that PWV could improve cardiovascular event prediction in models that included standard risk factors. Consequently, it might therefore enable better identification of populations at high-risk of cardiovascular morbidity and mortality. The present review is focused on a survey of different pharmacological therapeutic options for decreasing arterial stiffness. The influence of several groups of drugs is described: antihypertensive drugs (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta-blockers, diuretics, and nitrates), statins, peroral antidiabetics, advanced glycation end-products (AGE) cross-link breakers, anti-inflammatory drugs, endothelin-A receptor antagonists, and vasopeptidase inhibitors. All of these have shown some effect in decreasing arterial stiffness. Nevertheless, further studies are needed which should address the influence of arterial stiffness diminishment on major adverse cardiovascular and cerebrovascular events (MACCE).

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“…A recent study by Kaya et al . found that this treatment helps to ameliorate insulin resistance and aortic stiffness in PCOS patients (154). …”

Section: Current Research and Future Perspectivementioning

confidence: 99%

Polycystic ovary syndrome current status and future perspective

2014

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Polycystic ovary syndrome (PCOS) is a widespread reproductive disorder that encompasses many associated health conditions and has an impact on various metabolic processes. PCOS is depicted by hyperandrogenism, polycystic ovaries, and anovulation. It increases the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. The etiology of the disease remains unclear, and the subjective phenotype makes a united diagnosis difficult among physicians. It seems to be a familial genetic syndrome caused by a combination of environmental and genetic factors. It can be linked with metabolic disorders in first-degree family members. PCOS is the cause of up to 30% of infertility in couples seeking treatment. Currently, there is no cure for PCOS. Despite the growing incidence of this syndrome, limited research has been done that encompasses the entirety of PCOS spectrum. In this review, the current status and possible future perspective will be discussed.

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The effects of treatment with drospirenone/ethinyl oestradiol alone or in combination with metformin on elastic properties of aorta in women with polycystic ovary syndrome

Abstract: We demonstrated an improvement in the elastic parameters of the aorta by adding metformin to OCP treatment. We suggest that metformin plus OCP treatment may decrease cardiovascular disease risk in women with PCOS.

Cited by 15 publications

References 42 publications

Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

Metformin improves endothelial function and carotid intima media thickness in patients with PCOS

Arterial Stiffness and Cardiovascular Therapy

Polycystic ovary syndrome current status and future perspective

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