“…However, current non-invasive measures of arterial stiffness are BP-dependent, making it hard to distinguish the beneficial BP-lowering effects from those caused by de-stiffening of the arterial wall. In addition to BP-lowering drugs, statins, antidiabetic drugs, advanced glycation end-products, cross-link breakers, and anti-inflammatory drugs have been proposed to lower arterial stiffness, but are still under development or validation [80]. On the other hand, favourable effects of physical activity [81][82][83][84][85] and weight reduction [86] on arterial stiffness have been described in both healthy individuals and in patients with cardiovascular risk factors.…”