The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy

Moraes, Andrea B; Haidar, Mauro Abi; Júnior, José Maria Soares; Simões, Manuel de Jesus; Baracat, Edmund Chada; Patriarca, Marisa Teresinha

doi:10.1016/j.ejogrb.2009.04.007

Cited by 44 publications

(30 citation statements)

References 26 publications

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“…22 Treatment can also be done with phytoestrogens, compounds that are found in plants, fruits, vegetables and grains and which have some properties and chemical structure similar to estrogen, binding to its receptor. 22,24 Phytoestrogens have less effect compared to estrogen to tackle severe vasomotor symptoms, but they can be an alternative for patients with phobia of classical hormonal therapy, even after explanations of the risks and benefits.…”

mentioning

confidence: 99%

Female aging

Sorpreso

Júnior²,

Fonseca³

et al. 2015

Rev. Assoc. Med. Bras.

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Conflict of interest: noneFemale aging is a process that involves hypoestrogenism time, the individual impact on each woman, and what we can do as experts to reduce morbidity and provide quality of life. This natural process in the female life cycle has been of concern to women after menopause. Changes in different biophysical and psychosocial aspects, and their individual experiences, have repercussions on the lives of patients seeking specialized and multidisciplinary support to reduce the harmful effects of prolonged hypoestrogenism. Overweight and obesity, inadequate living habits and the presence of multi-morbidities cause damage to the quality of life and impact the functional capacity. Behavioral prescription and hormone therapy are among the treatments given to ease symptoms and reduce morbidity. A better understanding of these factors can help identify groups that require more care after menopause.Keywords: post-menopause, women, aging.Aging is a physiological process in life and, in women, it is influenced by hypoestrogenism the greater their longevity. The increase in life expectancy among women brought changes in the mortality panorama. 1 Currently, the prevalence of chronic diseases, malignancies and repercussions of hypoestrogenism in each individual serves as motivation for health professionals in clinical and gynecological settings to offer prevention and promotion actions for women seeking quality of life and reduced morbidity. 2,3Also, concern about the quality of life and prevention of chronic diseases and cancer are the demands of women seeking a gynecologist.3,4 The notion of health has been a concern of the very patients interested in weight maintenance, adoption of healthy lifestyle habits, cessation of legal and illegal adictions, and the use of medications for adequate control of chronic diseases. 5Changes in biophysical aspects also affect the quality of life caused by prolonged hypoestrogenism related to urogenital disorders, changes in sexual behavior and libido, memory, skin tropism, effects on lipid profile, and bone metabolism. Psychosocial factors contribute to a positive or negative perception of women's health, which depends on how she experiences and sees life after menopause.7 There are occurrences such as loss of loved ones, change in marital status, retirement process, and prior preparation of this phase in which women turn their attention to themselves, their achievements and accomplishments, their wishes and needs. 8 It is known that age, overweight and obesity, smoking, and the presence of multi-morbidities impair the quality of life and impact the functional capacity.9 According to Fonseca et al., the most relevant information in medical history declared at the time of the initial treatment in women after menopause were: hypertension (44.94%), diabetes (10.1%), smoking (8.39%), thyroid disorders (7.7%), malignancies (6.41%), cardiovascular disease (17.1%), dyslipidemia (0.88%) and psychiatric disorders (0.06%).

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mentioning

confidence: 99%

Female aging

Sorpreso

Júnior²,

Fonseca³

et al. 2015

Rev. Assoc. Med. Bras.

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“…Son et al reported an increase of tropoelastin and fibrillin-1 in aged human skin by topical 17 β-estradiol treatment [9]. In addition to estrogen, there are reports about the evaluation of cutaneous healing and improvement in postmenopausal women skin using topical selective ER modulators [33] or phytoestrogen treatment [19]. However, the effect of daidzein on the expressional changes of dermal matrix proteins such as collagen type IV, elastin, and fibrillin-1 has not been studied extensively.…”

Section: Effect Of Daidzein On the Expression Of Ecm Componentsmentioning

confidence: 99%

“…The effect of topical application of genistein on postmenopausal women skin has been reported. Topical application of genistein stimulated production of hyaluronic acid [18] and increases of epidermal thickness as well as blood vessels [19]. Despite the effective action of phytoestrogens on aged human skin, the precise action mechanism of daidzein, another wellknown phytoestrogen, in skin cells is still unknown.…”

Section: Introductionmentioning

confidence: 99%

The Phytoestrogenic Effect of Daidzein in Human Dermal Fibroblasts

Kim¹,

Hong²,

Lee³

2014

Journal of the Society of Cosmetic Scientists of Korea

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Abstract:Estrogen deficiency results in a reduction of skin quality and function in postmenopausal women. Over the past decade, many studies have supported that estrogen provides anti-aging effects as a result of the ability of estrogen to prevent skin collagen decline, restore skin elasticity, and increase skin hydration in postmenopausal women skin. Due to their structural similarity with estrogen, isoflavones have been called phytoestrogens. Photoprotective effects of isoflavones are well established while their estrogenic-like activities are not fully understood in human skin. In this study, we investigated whether daidzein, an effective isoflavone, has phytoestrogenic activity and induces transcriptional change of extracellular matrix components in dermal fibroblasts. We examined the luciferase activity of daidzein and β -estradiol using transiently transfected NIH3T3-ERE cells. The estrogenic receptor-dependent transcriptional activity was increased in a dose-dependent manner when treated with daidzein, with a maximum of 2.5-fold induction at 10 µg/mL of daidzein compared with non-treated control. In addition, daidzein significantly in creased the expressions of collagen 1) † 주 저자 (e-mail: misunkim@lgcare.com) 2014 type I, collagen type IV, elastin, and fibrillin-1 in human dermal fibroblasts. By comparing with the effects of β -estradiol through out all the experiments, we confirmed that daidzein had estrogenic activity and function in fibroblasts. These results suggest that daidzein-based application, having both photoprotective and phytoestrogenic effects, may be a powerful approach for skin anti-aging of postmenopausal women.

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“…Zaobserwowano poprawę grubości naskórka, wzrost liczby brodawek skóry, ilości fibroblastów i utkania naczyniowego. Krem z fitoestrogenem także korzystnie wpływał na jakość naskórka i unaczynienie skóry [17]. Wciąż nadzieję budzą aktywne preparaty do leczenia miejscowego, np.…”

Section: Fitoestrogeny W Nutriceutykach I Kosmeceutykachunclassified

How to prevent menopausal consequences for skin?

Wojnowska¹

2013

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StreszczenieWspółcześnie 1/3 życia kobiet przypada na okres po menopauzie. Istotne przeobrażenia hormonalne dokonujące się w tym czasie w organizmie kobiety prowadzą do zmian w strukturze i funkcjonowaniu skóry. Starzenie hormonalne charakteryzuje się atrofią naskórka, suchością i ścieńczeniem skóry, formowaniem drobnych zmarszczek i opóźnionym gojeniem ran. W starzeniu skóry twarzy biorą udział zarówno czynniki wewnętrzne -genetyczne i hormonalne, jak i zewnętrzne -przede wszystkim przewlekła ekspozycja na promienie słoneczne. Układowe lub miejscowe estrogenowe leczenie zastępcze poprawia grubość skóry, zawartość kolagenu, syntezę włókien sprężystych i nawilżenie skóry. Jednak długotrwałe leczenie zastępcze estrogenami może powodować działania uboczne, dlatego też poszukuje się alternatywnych metod terapii skóry. W pracy omówiono możliwo-ści poprawy jakości skóry, w tym różne preparaty dermatologiczne i niechirurgiczne techniki zabiegowe.Słowa kluczowe: menopauza, starzenie skóry, estrogen, kosmeceutyki, toksyna botulinowa, wypełniacze, peeling, laser. SummaryCurrently, women spend one-third of their lives in a postmenopausal state. At this time significant hormonal changes occur, leading to marked structural and functional skin alterations. Hormonal aging of the skin is linked to such symptoms as: epidermal atrophy, dryness, thinning, fine wrinkling and delayed wound healing. Facial aging is caused by both intrinsic factors -hormonally and genetically determined -and extrinsic, especially chronic sun exposure. Systemic or local estrogen replacement therapy makes it possible to improve skin thickness, the level of total skin collagen, synthesis of elastic fibers and skin moisture. Long-term estrogen replacement therapy may lead to harmful side effects, so other effective methods are being researched. This article discusses possible ways of treatment used for skin rejuvenation: different dermatological preparations and nonsurgical techniques.

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The effects of topical isoflavones on postmenopausal skin: Double-blind and randomized clinical trial of efficacy

Cited by 44 publications

References 26 publications

Female aging

Female aging

The Phytoestrogenic Effect of Daidzein in Human Dermal Fibroblasts

How to prevent menopausal consequences for skin?

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