The Effects of Topical Carvacrol Application on Wound Healing Process in Male Rats

Abstract

Carvacrol containing products such as Origanum onites have been used as phytotherapeutic agents in the treatment of serious skin injury. It has been suggested that carvacrol is the active component of these herbs because of its anti-microbial property. With the anti-microbial activity and as an ingredient of these herbs, carvacrol is a promising molecule for the treatment of skin injury. In the present study, we have evaluated the efficacy of carvacrol on healing progress after excisional skin injury. Here, Wistar-Albino rats were divided into two groups and treated with carvacrol and vehicle. Carvacrol was administrated topically at a concentration of %12.5 for the 5 consecutive days after excisional skin injury. Tissue samples were harvested on days 3 rd , 8th and 12 th after injury. Significant beneficial effect of carvacrol was observed at the end of the experiment. In the acute phase of the injury, carvacrol treatment increased tissue granulation and decreased wound depth moderately. These effect of carvacrol was associated with increased TNF-α. However, at the second half of the experiment the elevated level of TGF-B 1 was observed as compared with control animals. The level of IL-1 β was increased in carvacrol treated animals only on day 8. Here, we provide evidence that carvacrol improves wound healing by regulating pro-inflammatory molecules TNF-α, IL-1 β and TGF-β 1 .

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

“…Subsequently, Gunal et al . evaluated the healing effect of a dressing containing carvacrol (12.5%) diluted in sunflower oil (2%) for 12 days.…”

Impregnation of cellulose acetate films with carvacrol using supercritical carbon ioxide

“…Milovanovic et al [19] also showed that the mechanisms of release of thymol from CA beads followed Fickan and non-Fickan diffusion depending on the thymol impregnation yields as well as the release medium. The antibacterial activity of carvacrol has been already analyzed in many studies [9][10][11][12][13]. Carvacrol's hydrophobic nature as well as its free hydroxyl function are two main factors responsible for its antibcterial nature [12].…”

“…Carvacrol (5-isopropyl-2-methyl phenol) is a natural monotherpenic phenol found in isolates of Lamiaceae family (i.e. oregano, thyme) [9,[11][12][13]. It also displays anti-inflammatory and antioxidant activity [9,11,12].…”

“…oregano, thyme) [9,[11][12][13]. It also displays anti-inflammatory and antioxidant activity [9,11,12]. Because carvacrol has been approved as a safe food additive by the US Food and Drug Administration (2006) and due to its beneficial biological activities, it can be used both in food packaging and in wound dressings [9,[11][12][13].…”

“…It also displays anti-inflammatory and antioxidant activity [9,11,12]. Because carvacrol has been approved as a safe food additive by the US Food and Drug Administration (2006) and due to its beneficial biological activities, it can be used both in food packaging and in wound dressings [9,[11][12][13]. Since carvacrol is prone to degradation and rapid evaporation, it is important to find a suitable technique to prolong its activity [9,12,13].…”