The Effects of the Therapeutic Regimen Used in Hodgkin Lymphoma and the Correlation with Prognosis Factors

Abstract

The Hodgkin lymphoma treatment is adapted to the disease type, disease stage and to an evaluation of the risk. The treatment is focused on the adjustment of the therapy to each patient depending on the age, toxicity risk on short and long term and the relapse risk. The study proposes the evaluation of the response to the treatment further to the administration of different therapeutic regimens as well as the correlation with the negative diagnosis factors of Hodgkin lymphoma. This is a retrospective study on 71 patients diagnosed with Hodgkin lymphoma in the Hematology Department of Timisoara between January 2014 and December 2017. The data obtained have been collected from a database and processed with the SPSS 20.0. software . In our study there were included 71 patients diagnosed with Hodgkin lymphoma with a medium age of 42.12�16.45 years old. By the time of the diagnosis, the patients showed the following hematological, biochemical and immunological parameters. The response to treatment is influenced by the presence of the negative prognosis factors : the age of �40 years old, extralymphatic infiltration, VSH ] 50mm/h , presence of general B signs, more than 3 lymph node sites affected, bulky disease and Ann-Arbor III and IV stages. The treatment of Hodgkin lymphoma is guided by the traditional clinic prognostic factors and by the laboratory which often represent a substitute marker for the biological characteristics which many times are not included in the standard evaluation.

Accomplishments and Failures in the Management of Fortress Sarmizegetusa Regia, a Unesco World Heritage Monument

“…See also GHEORGHIU 1998, 177-189. 29 MATEESCU 2016 For the temples at Sarmizegetusa Regia and the rest of Dacia see ANTONESCU 1984;CRIȘAN 1986;CRIȘAN 1993;GLODARIU/ IAROSLAVSCHI/RUSU 1988;RUSU-PESCARU 2005;FLOREA 2011;MATEESCU 2012;GHEORGHIU 2005, 202-208;, 193-220. 31 FLOREA 2011, 161.…”