The Effects of the Menstrual Cycle on the Incidence of Emesis and Efficacy of Ondansetron

Comparison of ondansetron & dexamethasone in prevention of postoperative nausea & vomiting in laparoscopic surgery

“…6 In our study the incidence of PONV is not related to increase BMI as also seen in study by Kranke et al 7 . There was no relationship between incidence of PONV and phases of menstrual cycle in our study and is supported by studies done by Panditrao et al 8 and Irwin et al 9 . There is no difference between the three inhalation anaesthetics currently used with regard to frequency or severity of postoperative nausea, vomiting, or both also seen byWallenborn.…”

Influence of the menstrual cycle on the incidence of nausea and vomiting after laparoscopic gynecological surgery: a pilot study

“…In the early postoperative period, the incidence of nausea but not of vomiting was decreased during the luteal phase. The results of this study were similar to studies that suggested that the early phase of the cycle increases risk of PONV [9][10][11], but differed with those that determined that the luteal phase was a predictor of PONV [12,13] and likewise to those studies that found no influence of the cycle on PONV [14,16,17]. Small, single-center studies may not have enough power to answer the question, but a subsequent metaanalysis may be helpful.…”

“…While the follicular phase of the menstrual cycle increased the risk for PONV in some studies [9][10][11], the luteal phase increased the risk in another [12]. Moreover both phases, follicular and luteal increased the risk in one study [13] but not in a multicentre study [14] or a factorial trial of six interventions for the prevention of PONV (IMPACT study) [8] (Table 1).…”

Sex-related differences in the efficacy of dexamethasone pretreatmentfor postoperative analgesia in patients undergoing laparoscopiccholecystectomy: a randomized controlled study

“…Gonadal hormones are associated with modulating pain intensity (19). A decrease in pain threshold and an increase in morphine consumption has been found in women with menstrual cycles, notably during the luteal phase (19,20). Our study also showed that the potential postoperative antiemetic effects of dexamethasone in women were greater than in men (reduction rate of PONV 16.4% vs. 7.8%).…”