Abbreviations: (ASAPS) American Society of Anesthesiologists physical status, (BG) blood glucose, (BMI) body mass index, (BUN) blood urea nitrogen, (DM) diabetes mellitus, (I&D) irrigation and debridement, (INR) international standardized ratio, (MI) myocardial infarction, (PJI) periprosthetic joint infection, (POD) postoperative day

No abstract

Acute hyperglycemia attenuates reductions in myocardial infarct size produced by isoflurane in dogs.

We conclude that reducing pain with intraperitoneal bupivacaine is effective, easy to administer, and without side-effects.

Background-Development of coronary collateral vessels is impaired in patients with diabetes mellitus. We tested the hypothesis that hyperglycemia alone attenuates collateral development and abolishes proliferative properties of myocardial interstitial fluid (MIF) by enhancing expression of matrix metalloproteinases (MMP) and angiostatin. Methods and Results-Chronically instrumented dogs were randomly assigned to receive an infusion of normal saline (control; nϭ9) or 70% dextrose in water to increase blood glucose to 350 to 400 mg/dL for 8 h/d (hyperglycemia; nϭ7) in the presence or absence (sham; nϭ9) of brief (2 minutes), repetitive coronary artery occlusions (1/h; 8/d for 21 days). Collateral perfusion increased to 41Ϯ11% and 49Ϯ6% of normal zone flow in control dogs on days 14 and 21 (PϽ0.05) but remained unchanged over 21 days in hyperglycemic and sham dogs (12Ϯ3% and 13Ϯ3%, respectively). A progressive reduction of the postocclusive peak reactive hyperemic response was also observed in control dogs (16Ϯ1 to 10Ϯ1 Hz · 10 2 on days 1 and 21, respectively) but not in hyperglycemic (17Ϯ2 to 20Ϯ2) or sham (17Ϯ2 to 16Ϯ1) dogs. Endothelial cell tube formation was produced by MIF obtained from control dogs but not hyperglycemic or sham dogs. Coincubation of MIF from hyperglycemic dogs with an angiostatin antibody restored endothelial cell tube formation. MMP-9 activity and expression of angiostatin were increased in dogs receiving exogenous glucose compared with controls Conclusions-Chronic hyperglycemia abolishes development of coronary collateral vessels by increasing MMP-9 activity and angiostatin expression in dogs.