The effects of taurine supplementation on diabetes mellitus in humans: A systematic review and meta-analysis

Tao, Xiaomei; Zhang, Zhanzhi; Yang, Zhenpeng; Rao, Benqiang

doi:10.1016/j.fochms.2022.100106

Cited by 19 publications

(14 citation statements)

References 58 publications

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“…The design of this study was based on the results of a systematic review and meta-analysis (PRISMA) [ 22 ]. The protocol for this study was registered with PROSPERO [ 23 ]. We used the following databases to conduct an electronic search: Pubmed, Cochrane library, Web of science, and Embase are all available online.…”

Section: Methodsmentioning

confidence: 99%

Zonisamide’s Efficacy and Safety on Parkinson’s Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review

Kong

Xi²,

Jiang

et al. 2022

BioMed Research International

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Objective. Clinical data has recently shown an association between Parkinson’s disease (PD), Dementia with Lewy bodies (DLB), and zonisamide. The purpose of this study was to thoroughly evaluate the efficacy and safety of zonisamide in PD and DLB. Methods.Pubmed, the Cochrane Library, Web of Science, and Embase databases were searched for all randomized clinical trials (RCTS) on the role of zonisamide in PD and DLB that were completed by April 18, 2022. UPDRS II (off) total score, UPDRS III total score, Daily “off” time, and UPDRS Part IV, Nos. 32, 33, and 34 were used as clinical efficacy endpoints. Adverse events reported in the RCTs will be considered in the final safety analysis. To better understand the effect of zonisamide on the efficacy and safety of PD and DLB, the UPDRS III total score and the six overlapping adverse events were examined in subgroups. Either a fixed effects model analysis (OR) or a random effects model analysis (MD) is used to figure out the mean difference (MD) and the relative risk. Results. Seven articles involving 1749 patients (916 PD and 833 DLB) were included in this study. Compared to the control group, zonisamide could significantly reduce the UPDRS III total score in patients with PD and DLB (WMD-2.27 [95% CI: -3.06, -1.48], p < 0.0001 ). For patients with PD, compared to the control group, zonisamide could significantly reduce the UPDRS II (off) total score (WMD-0.81 [95% CI: -1.36, -0.26], p = 0.004 ), daily “off” time (WMD-0.67 [95% CI: -1.10, 0.24], p = 0.002 ), and UPDRS part IV, No. 32 worsen (OR-3.48 [95% CI: 1.20, 10.10], p = 0.02 ). In terms of safety, compared with the control group, for patients with DLB, zonisamide could significantly increase the incidence of contusion (OR-0.60 [95% CI: 0.38, 0.96], p = 0.03 ) and may increase the probability of reduced appetite (OR-3.13 [95% CI: 1.61, 6.08], p = 0.0008 ). And for patients with PD, zonisamide may increase the probability of somnolence (OR-2.17 [95% CI: 1.25, 3.76], p = 0.006 ). Conclusions. For the analysis of the current study results, our results show that zonisamide could improve the motor function in patients with PD and DLB and improve the activities of daily living (off) and wearing off and decrease the duration of dyskinesia in patients with PD. In terms of safety, the use of zonisamide significantly increases the probability of contusion in patients with DLB and may increase the probability of reduced appetite in patients with DLB and somnolence in patients with PD. Zonisamide appears to be a new treatment option for patients with PD and DLB. However, the effectiveness and safety of zonisamide in the treatment of PD and DLB need to be further investigated.

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Section: Methodsmentioning

confidence: 99%

Zonisamide’s Efficacy and Safety on Parkinson’s Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review

Kong

Xi²,

Jiang

et al. 2022

BioMed Research International

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“…Taurine is considered a substitute in the event of magnesium deficiency. [12] The therapeutic effect of combined magnesium ion and taurine in treating diabetes has been proven to be superior to that of magnesium ion alone. [13] As a primary modulator of GK activity and a directly controllable factor in cell-based assays, a combination of the optimal magnesium ion concentration of 1.1 mM for GK activity with 2 mM taurine in the treatment of IR cells significantly increased glucose consumption and GK activity-the latter from 1.83 U/gprot to 4.29 U/gprot, an approximate 134.4% increase.…”

Section: Discussionmentioning

confidence: 99%

“…Glucose consumption was calculated using the following formula in order to select the optimal insulin concentration for model establishment. Subsequently, the treatment duration was varied (12,24,36, 48 h) to identify the optimal insulin processing time. Glucose Consumption (mmol/L) = (Glucose content in blank group supernatant − Glucose content in experimental group supernatant) (4) Experimental groupings and oil red O staining Cells were seeded in 35 mm dishes with 2 mL culture medium as per the earlier method.…”

Section: Mg 2+mentioning

confidence: 99%

Magnesium Ion-Dependent Activation of Glucokinase in Simulated Cytoplasmic System <em>in Vitro</em>

Pu,

Chen,

Diao

et al. 2023

Med. Res.

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Glucokinase (GK), as a key enzyme regulating carbohydrate metabolism, has been widely researched as a therapeutic target for diabetes. This study aimed to investigate the influence of magnesium ion concentration, ATP concentration, and enzyme concentration on the catalytic activity of GK by response surface. A cellular model of insulin resistance (IR) was established to observe the ameliorating effect of magnesium ion on IR by screening the concentration and duration of insulin action. The results indicated that the optimal concentrations for enzyme activity were found to be 1.1 mM for magnesium ion, 1.4 mM for ATP, and 0.5 U/mL for glucokinase. In the presence of taurine, the IR model was treated with magnesium ion (1.1 mM) can promote glucose consumption, GK activity and intracellular magnesium concentration in IR cells. Magnesium ion, as a key factor in GK-catalyzed glycolysis, showed a positive correlation between intracellular magnesium ions and the catalytic activity of GK within a certain concentration range. Therefore, magnesium ion could effectively promote carbohydrate metabolism and alleviate the progression of IR.

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“…Moreover, it’s worth noting that taurine can improve visual function and reduce the risk of cataracts at the same time [ 25 ]. Indeed, taurine is one of the most abundant amino acids in several tissues of the human eye, such as ciliary bodies, iris and cornea [ 26 , 27 ]. Besides, the unique structure and chemical functional groups of taurine molecular allow it combines with collagen molecular by chemical crosslinking [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Modification of Collagen Film via Surface Grafting of Taurine Molecular to Promote Corneal Nerve Repair and Epithelization Process

Liu

Zhang

Kong

et al. 2022

JFB

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Corneal defects can seriously affect human vision, and keratoplasty is the most widely accepted therapy method for visual rehabilitation. Currently, effective treatment for clinical patients has been restricted due to a serious shortage of donated cornea tissue and high-quality artificial repair materials. As the predominant component of cornea tissue, collagen-based materials have promising applications for corneal repair. However, the corneal nerve repair and epithelization process after corneal transplantation must be improved. This research proposes a new collagen-based scaffold with good biocompatibility and biological functionality enhanced by surface chemical grafting of natural taurine molecular. The chemical composition of collagen-taurine (Col-Tau) material is evaluated by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and its hydrophilic properties, light transmittance, swelling performance and mechanical tensile properties have been measured. The research results indicate that the Col-Tau sample has high transmittance and good mechanical properties, and exhibits excellent capacity to promote corneal nerve cell growth and the epithelization process of corneal epithelial cells. This novel Col-Tau material, which can be easily prepared at a low cost, should have significant application potential for the treating corneal disease in the future.

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The effects of taurine supplementation on diabetes mellitus in humans: A systematic review and meta-analysis

Cited by 19 publications

References 58 publications

Zonisamide’s Efficacy and Safety on Parkinson’s Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review

Zonisamide’s Efficacy and Safety on Parkinson’s Disease and Dementia with Lewy Bodies: A Meta-Analysis and Systematic Review

Magnesium Ion-Dependent Activation of Glucokinase in Simulated Cytoplasmic System <em>in Vitro</em>

Modification of Collagen Film via Surface Grafting of Taurine Molecular to Promote Corneal Nerve Repair and Epithelization Process

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