Magnesium Ion-Dependent Activation of Glucokinase in Simulated Cytoplasmic System <em>in Vitro</em>
Xinyi Pu,
Boyu Chen,
Xiaozhen Diao
et al.
Abstract:Glucokinase (GK), as a key enzyme regulating carbohydrate metabolism, has been widely researched as a therapeutic target for diabetes. This study aimed to investigate the influence of magnesium ion concentration, ATP concentration, and enzyme concentration on the catalytic activity of GK by response surface. A cellular model of insulin resistance (IR) was established to observe the ameliorating effect of magnesium ion on IR by screening the concentration and duration of insulin action. The results indicated th… Show more
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