The effects of taurine on perfused heart muscle malondialdehyde levels

Kaplan, Birsen; Aricioglu, Aysel; Erbaş, Deniz; Erbaş, Semra; Türközkan, Nurten

doi:10.1016/0306-3623(93)90427-y

Cited by 14 publications

(5 citation statements)

References 12 publications

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“…[32] have demonstrated that TAU exerts a protective effect on the biomembranes against oxidative damage by trapping HOCl. It interacts with peroxide ions to form stable products [34]. Moreover, TAU might activate Na + , K + ‐ATPase and ameliorate the reduction in the mitochondrial membrane potential that is known as the membrane stabilizing activity [31].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of taurine against alendronate‐induced gastric damage in rats

Şener

Şehirli

Çetınel

et al. 2004

Fundamemntal Clinical Pharma

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Alendronate (ALD) causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether taurine (TAU), a semi-essential amino acid and an antioxidant, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg ALD by gavage for 4 days, either alone or following treatment with TAU (50 mg/kg, i.p.). On the last day of treatment, following drug administration, pylorus ligation was performed and 2 h later, rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of ALD induced significant gastric damage, increasing lipid peroxidation, MPO activity and collagen content, as well as decreasing tissue GSH levels. Treatment with TAU prevented the damage and also the changes in biochemical parameters. Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects.

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Section: Discussionmentioning

confidence: 99%

Protective effect of taurine against alendronate‐induced gastric damage in rats

Şener

Şehirli

Çetınel

et al. 2004

Fundamemntal Clinical Pharma

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“…Taurine functions as an anti-oxidant in a variety of biological systems 1,2 and protects against oxidative damage under many conditions, decreasing rates of malondialdehyde formation. 36 Pre-operative infusion of taurine during myocardial revascularization reduces reperfusion injury. 37 Taurine reduces oxidant injury accompanied with decreased lipid peroxidation and, thereby, ameliorates streptozotocin-induced diabetic nephropathy in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Taurine functions as an anti‐oxidant in a variety of biological systems 1,2 and protects against oxidative damage under many conditions, decreasing rates of malondialdehyde formation 36 . Pre‐operative infusion of taurine during myocardial revascularization reduces reperfusion injury 37 .…”

Section: Discussionmentioning

confidence: 99%

Taurine Inhibits Development Of Atherosclerotic Lesions In apolipoprotein E‐Deficient Mice^‡

Kondo

Toda

Kitajima

et al. 2001

Clin Exp Pharma Physio

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1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholesterol was significantly elevated after 12 weeks treatment with taurine. This elevation was due to increases in very low-density lipoprotein- and low-density lipoprotein-cholesterol. 3. Despite such effects on serum lipoproteins, analysis using en face oil red O staining revealed that taurine reduced the area of arterial lipid accumulation by 28%, as measured quantitatively as an index of atherosclerosis. Histological examination also demonstrated a decrease in the size of aortic lesions in taurine-treated mice. 4. Serum levels of thiobarbituric acid reactive substances (TBARS) in apoE-deficient mice were higher than in normolipidaemic C57BL/6J mice. Serum TBARS levels were significantly decreased by 12 weeks treatment of apoE-deficient mice with taurine. 5. Thus, taurine prevents the formation of atherosclerotic lesions, independently of serum cholesterol levels, and the results suggest that the anti-oxidative effects of taurine are related to its anti-atherosclerotic actions.

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“…It should be taken into consideration that a vicious cycle is observed between sodium and calcium, and more sodium is available for calcium entry via the Na + /Ca 2+ exchanger, exacerbating calcium overload (165). Firstly, taurine exerts great anti-oxidant activity by preventing calcium overload during reperfusion (166)(167)(168) and by protecting the myocardium from LPO products (169). In particular, taurine has also been shown to regulate the activity of the sarcoplasmic reticulum (SR) Ca 2+ ATPase, given that ATPase retains cytosolic calcium to normal levels, promoting cellular calcium homeostasis (170).…”

Section: The Regulatory Importance Of Taurine In Ischemia and Reperfusionmentioning

confidence: 99%

Protective role of taurine against oxidative stress (Review)

et al. 2021

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Taurine is a fundamental mediator of homeostasis that exerts multiple roles to confer protection against oxidant stress. The development of hypertension, muscle/neuroassociated disorders, hepatic cirrhosis, cardiac dysfunction and ischemia/reperfusion are examples of some injuries that are linked with oxidative stress. The present review gives a comprehensive description of all the underlying mechanisms of taurine, with the aim to explain its anti-oxidant actions. Taurine is regarded as a cytoprotective molecule due to its ability to sustain normal electron transport chain, maintain glutathione stores, upregulate anti-oxidant responses, increase membrane stability, eliminate inflammation and prevent calcium accumulation. In parallel, the synergistic effect of taurine with other potential therapeutic modalities in multiple disorders are highlighted. Apart from the results derived from research findings, the current review bridges the gap between bench and bedside, providing mechanistic insights into the biological activity of taurine that supports its potential therapeutic efficacy in clinic. In the future, further clinical studies are required to support the ameliorative effect of taurine against oxidative stress. Contents1. Introduction 2. The role of taurine in homeostasis 3. The role of taurine against oxidative stress and its underlying molecular mechanisms 4. The beneficial effect of taurine against neuro-associated disorders 5. The anti-oxidant efficacy of taurine against cardiacassociated oxidative stress 6. The regulatory importance of taurine in ischemia and reperfusion 7. The anti-oxidant efficacy of taurine against muscle-associated disorders 8. The anti-oxidant efficacy of taurine against hepatic-associated stress 9. The anti-oxidant properties of taurine in various toxicmediated insults 10. Conclusions

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The effects of taurine on perfused heart muscle malondialdehyde levels

Cited by 14 publications

References 12 publications

Protective effect of taurine against alendronate‐induced gastric damage in rats

Protective effect of taurine against alendronate‐induced gastric damage in rats

Taurine Inhibits Development Of Atherosclerotic Lesions In apolipoprotein E‐Deficient Mice^‡

Protective role of taurine against oxidative stress (Review)

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The effects of taurine on perfused heart muscle malondialdehyde levels

Cited by 14 publications

References 12 publications

Protective effect of taurine against alendronate‐induced gastric damage in rats

Protective effect of taurine against alendronate‐induced gastric damage in rats

Taurine Inhibits Development Of Atherosclerotic Lesions In apolipoprotein E‐Deficient Mice‡

Protective role of taurine against oxidative stress (Review)

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Resources

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Taurine Inhibits Development Of Atherosclerotic Lesions In apolipoprotein E‐Deficient Mice^‡