Protective effect of taurine against alendronate‐induced gastric damage in rats

Abstract

Alendronate (ALD) causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether taurine (TAU), a semi-essential amino acid and an antioxidant, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg ALD by gavage for 4 days, either alone or following treatment with TAU (50 mg/kg, i.p.). On the last day of treatment, following drug administration, pylorus ligation was performed and 2 h later, rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of ALD induced significant gastric damage, increasing lipid peroxidation, MPO activity and collagen content, as well as decreasing tissue GSH levels. Treatment with TAU prevented the damage and also the changes in biochemical parameters. Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects.

Modulation of indomethacin‐induced gastric injury by spermine and taurine in rats

“…Taurine failed to affect the elevated gastric acidity. Similarly, taurine had no significant effect on the increased gastric acidity reported in alendronate-induced gastric damage in rats [36]. The gastroprotective effects of spermine [37] and taurine [36] as represented by reduction in GUI were previously demonstrated.…”

“…Similarly, taurine had no significant effect on the increased gastric acidity reported in alendronate-induced gastric damage in rats [36]. The gastroprotective effects of spermine [37] and taurine [36] as represented by reduction in GUI were previously demonstrated. The suppression of acid secretion by spermine might be attributed to uncoupling of the gastric K + /H + exchange pump in the secretory membrane, thus decreasing the ATPase-mediated uptake of H + .…”

“…Spermine was reported to interfere with NF-κB activating pathway [9] that leads to the suppression of proinflammatory cytokines synthesis including TNF, interleukins-1 and 6, and macrophage inflammatory proteins-1α and -1β (MIP-1α and MIP-1β) [8]. Taurine has been previously demonstrated in indomethacin- [17] and alendronateinduced gastric injuries [36] to suppress neutrophil infiltration. Results of the present study confirmed the previous studies, suppression of neutrophil infiltration by taurine might be attributed to the scavenging of HOCl to form TauCl that facilitate the observed gastric NO recovery.…”

The potential impact of new effervescent alendronate formulation on compliance and persistence in osteoporosis treatment

“…The correlation between GI AE with increased pH and inflammation has been confirmed in these models using gastro protective and anti-inflammatory agents, showing a decrease in the occurrence and magnitude of these AE [43][44][45][46][47][48]. Thus, in the last years, different oral formulations than tablets have been tested and proposed for osteoporosis treatment [49].…”

Effects of Taurine Supplementation on Heat Shock Protein 70 and In Vitro Protein Syntheses in Liver of Broiler Chicks under Chronic Heat Stress

“…타우린은 담즙산과 결합 (Ito et al, 2004), 세포 내 삼투압 조 절 (Schaffer et al, 2010), 항산화 (Kocak-Toker et al, 2005), 세 포손상 예방 (Sener et al, 2005) 및 고온 스트레스 완화 (Shim et al, 2006) (Yan et al, 2009), hsp70 (Mahmoud et al, 2003) 및 hsp90 (Lei et al, 2009) …”