The effects of sugar-free chewing gums on dental plaque regrowth: A comparative study

Pizzo, Giuseppe; Licata, Maria Ester; Cara, M; Pizzo, Ignazio; Guiglia, Rosario; Melilli, Dario

doi:10.1016/j.jdent.2007.01.008

Cited by 9 publications

(2 citation statements)

References 21 publications

(37 reference statements)

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“…They also include chlorhexidine [ 42 ] and copper chlorophyllin [ 43 ]. Hydrogen peroxide [ 44 ] and zinc [ 45 ] are antibacterial and antiviral agents, as are pycnogenol [ 46 ], stannous EDTA [ 47 ], sulfathiazole [ 11 ], urea [ 48 , 49 ], zirconium silicate [ 50 – 52 ], and also fluoride [ 53 – 56 ]. Among these drugs, chlorhexidine, hydrogen peroxide, sulfathiazole, and zinc have more potential to be loaded in chewing gum and as an oral disease remedy [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

Chewing Gums as a Drug Delivery Approach for Oral Health

Banakar

Moayedi

Shamsoddin³

et al. 2022

International Journal of Dentistry

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Background. Drug delivery approaches with the shortest therapeutic period and the lowest side effects have always been considered a sublime target in the medical sciences. Among many delivery methods, chewing gum could be perceived as a promising drug carrier that can carry several types of drugs for oral health. These drug carriers could represent optimal therapeutic time and lower side effects due to their sustained release capability and lower required thresholds for the drug compared with other delivery approaches. The convenient use in the oral cavity’s local environment and the ability to locally carry multiple drugs are considered the main advantages of this delivery approach. Aim. This review aimed to explore chewing gum as a promising drug carrier that can carry several types of drugs for oral health. Materials and Methods. Articles were searched for on PubMed, ISI, SCOPUS, Google Patents, the Royal Society of Chemistry website, and electronic databases using MESH terms and the following keywords: (“Gum” OR “Chewing gum”) and (“Drug delivery OR Drug delivery systems”) in the English language. No time limit was applied, and all documents as of August 30th, 2020 were retrieved. Results. Gum-drug interactions, mechanisms of release, and formulations of the drugs might all play a role in this versatile delivery method. Accordingly, chewing gum-based carriers may be presented as a plausible candidate for drug delivery in oral diseases. Conclusion. Gum-driven drugs could be introduced as promising candidates for treating oral diseases due to their ability to deliver the proper local dosages of active ingredients, short contact time, biocompatibility, and biodegradable chemical structures.

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Section: Resultsmentioning

confidence: 99%

Chewing Gums as a Drug Delivery Approach for Oral Health

Banakar

Moayedi

Shamsoddin³

et al. 2022

International Journal of Dentistry

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“…Chewing of regular sugar-free gum dislodges loosely bound bacteria from the oral mucosa [100] and inhibits regrowth and maturation of oral biofilm on occlusal surfaces [101] (Figure 1). Nonetheless, there is no unanimous judgment on a chewing gum-induced reduction of biofilm regrowth on smooth lingual and buccal surfaces and a relation between biofilm removal directly after a single gum chew has not been firmly established [102][103][104], not even when abrasive agents were included in the gum [105]. Therefore, the EFSA has concluded that the claim that the chewing of regular sugar-free gum 'reduces oral biofilm formation' is unsubstantiated [102], although this conclusion does not rule out the possibility that the chewing of gum can modify oral biofilm composition toward a less cariogenic one.…”

Section: Effects On Biofilm Formation Composition and Removalmentioning

confidence: 99%

Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare

Weßel

Mei

Maitra³

et al. 2016

Expert Opinion on Drug Delivery

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Evidence for oral-health benefits of chewing gum additives is hard to obtain due to their relatively low concentrations and rapid wash-out. Clinical effects of gum additives are overshadowed by effects of increased mastication and salivation due to the chewing of gum and require daily chewing of gum for prolonged periods of time. Future studies on active ingredients should focus on specifically targeting pathogenic bacteria, whilst leaving the healthy microbiome unaffected.

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