Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare

Weßel, Stefan; Mei, Henny C. van der; Maitra, Amarnath; Dodds, Michael; Busscher, Henk J.

doi:10.1080/17425247.2016.1193154

Cited by 36 publications

(33 citation statements)

References 111 publications

(123 reference statements)

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“…[138,139] Currently, marketed products of chewing gum contain chlorhexidine as an antiplaque agent (e.g. Recent evidence has indicated that chewing gum is an interesting and promising carrier for antiplaque agents, due to its longer residence time in the mouth than toothpaste or rinses.…”

Section: Other Systemsmentioning

confidence: 99%

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

2017

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Micro-organism resistance is an important challenge in modern medicine due to the global uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMPs) symbolize a new family of antibiotics, which have stimulated research and clinical interest as new therapeutic options for infections. They represent one of the most promising antimicrobial substances, due to their broad spectrum of biological activity, against bacteria, fungi, protozoa, viruses, yeast and even tumour cells. Besides, being antimicrobial, AMPs have been shown to bind and neutralize bacterial endotoxins, as well as possess immunomodulatory, anti-inflammatory, wound-healing, angiogenic and antitumour properties. In contrast to conventional antibiotics, which have very defined and specific molecular targets, host cationic peptides show varying, complex and very rapid mechanisms of actions that make it difficult to form an effective antimicrobial defence. Importantly, AMPs display their antimicrobial activity at micromolar concentrations or less. To do this, many peptide-based drugs are commercially available for the treatment of numerous diseases, such as hepatitis C, myeloma, skin infections and diabetes. Herein, we present an overview of the general mechanism of AMPs action, along with recent developments regarding carriers of AMPs and their potential applications in medical fields.

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Section: Other Systemsmentioning

confidence: 99%

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

2017

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“…Indeed, one of the goals of oral hygiene is to reduce the amount of pathogenic bacteria, shifting the oral microbiome towards a less pathogenic one. [13,53] In this regard, active substances contained in the mouthrinses should ideally act progressively, with a gradual change in the composition of the oral biofilm. [13] One possible approach is the use of mouthrinses with antibacterial compounds which inhibit pathogenic bacteria and maintain bacteria associated with a healthy microbiota.…”

Section: Expert Opinionmentioning

confidence: 99%

“…[13,53] In this regard, active substances contained in the mouthrinses should ideally act progressively, with a gradual change in the composition of the oral biofilm. [13] One possible approach is the use of mouthrinses with antibacterial compounds which inhibit pathogenic bacteria and maintain bacteria associated with a healthy microbiota. [2,13] Among the various candidate molecules, HA and triclosan demonstrate the most promise.…”

Section: Expert Opinionmentioning

confidence: 99%

“…Tooth brushing, interproximal toothbrushes, dental floss, dentifrices, gels, mouthrinses, chewing gums have all been described as efficacious in home maintenance programs. [5,[9][10][11][12][13] In particular, mouthrinses are usually used to support conventional tooth brushing in an attempt to reduce accumulation of oral plaque. [5,9,10,[14][15][16][17][18][19][20] They even can be used as the only oral care for patients unable to brush either after surgery or because of the motor or cognitive limitations (elderly or special needs patients).…”

Section: Introductionmentioning

confidence: 99%

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Mouthwashes in the 21^st century: a narrative review about active molecules and effectiveness on the periodontal outcomes

Tartaglia

Kumar

Fornari³

et al. 2016

Expert Opinion on Drug Delivery

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Poor oral hygiene is a major risk factor for oral diseases. Regular home-based care is essential to maintain good oral hygiene. In particular, mouthrinses can support conventional tooth brushing in reducing accumulation of oral plaque. Areas covered: The most common molecules contained in mouthrinses (chlorhexidine, essential oils, cetyl pyridinium chloride, triclosan, octeneidine, delmopinol, polyvinylpyrrolidone, hyaluronic acid, natural compounds) are discussed, together with relevant clinical and in vitro studies, focusing on their effects on periodontal health. Currently, chlorhexidine is the most efficacious compound, with both antiplaque and antibacterial activities. Similar results are reported for essential oils and cetyl pyridinium chloride, although with a somewhat reduced efficacy. Considering the adverse effects of chlorhexidine and its time-related characteristics, this molecule may best be indicated for acute/short-term use, while essential oils and cetyl pyridinium chloride may be appropriate for long-term, maintenance treatment. Expert opinion: The literature has not clearly demonstrated which compound is the best for mouthrinses that combine good efficacy and acceptable side effects. Research should focus on substances with progressive antibacterial activity, prompting a gradual change in the composition of oral biofilm and mouthrinses that combine two or more molecules acting synergistically in the mouth.

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“…Sus principales agentes patógenos son el Streptococcus mutans (S. mutans) y Porphyromonas gingivalis (P. gingivalis) (2,3) . Para mantener la salud de los tejidos bucales se requieren de cepillos dentales, dentífricos, hilo dental y antisépticos bucales (4)(5)(6) . El gluconato de clorhexidina (CHX) es la primera elección (7) , porque conjuga los efectos antibiopelícula/antibacteriano.…”

Section: Mensajes Clave Introducciónunclassified

Actividad antimicrobiana in vitro del camu camu (Myrciaria dubia) contra microorganismos orales: una revisión sistemática

Pardo-Aldave

Pareja-Vásquez

Guillén

et al. 2019

Rev Peru Med Exp Salud Publica

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Objetivos. Evaluar la actividad antimicrobiana de la Myrciaria dubia sobre microorganismos orales. Materiales y métodos. Se realizó una revisión sistemática de la literatura siguiendo las recomendaciones PRISMA mediante búsquedas en Pubmed, LILACS, SciELO, ProQuest, EBSCO y Google Scholar, de estudios publicados durante 2008 y 2018. Resultados. Se recopilaron 11 estudios, in vitro, todos los estudios evidenciaron actividad antimicrobiana positiva, principalmente por cada una de las partes de sus frutos, sobre grampositivos. Sin embargo, dicha actividad fue comparada con clorhexidina en solo dos estudios y en otro resultó ser mejor que un antibiótico. Se detectó un alto riesgo de sesgo en la mayoría de estudios. Los compuestos fenólicos incluidos polifenoles y acilfloroglucinoles fueron señalados como los responsables de su actividad. Conclusiones. Existe evidencia sobre la actividad antimicrobiana de M. dubia. Su estudio como antimicrobiano contra microorganismos orales es aún incipiente, pero se advierte un gran potencial debido a los fitoquímicos potentes que posee. Además, se necesita más estudios de calidad, que comparen su actividad versus antisépticos orales y sobre más microorganismos asociados a caries dental y enfermedad periodontal.

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Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare

Cited by 36 publications

References 111 publications

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

Mouthwashes in the 21^st century: a narrative review about active molecules and effectiveness on the periodontal outcomes

Actividad antimicrobiana in vitro del camu camu (Myrciaria dubia) contra microorganismos orales: una revisión sistemática

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Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare

Cited by 36 publications

References 111 publications

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

Current state of a dual behaviour of antimicrobial peptides—Therapeutic agents and promising delivery vectors

Mouthwashes in the 21st century: a narrative review about active molecules and effectiveness on the periodontal outcomes

Actividad antimicrobiana in vitro del camu camu (Myrciaria dubia) contra microorganismos orales: una revisión sistemática

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Product

Resources

About

Mouthwashes in the 21^st century: a narrative review about active molecules and effectiveness on the periodontal outcomes