The Effects of Subarachnoid Injections of Iron-Containing Substances on the Central Nervous System

Further Observations on the Syndrome of Chronic Encephalitis and Epilepsy

“…Each continued to be neurologi cally stable after hemispherectomy except for the development in one of the patients of superficial cerebral hemosiderosis [2][3][4] in the 11th post operative year, which was promptly recognized and has responded well to the appropriate CSF shunt.…”

Superficial Siderosis of the Central Nervous System: Neuroradiological Evaluation of Two Cases

“…Systemic hemo chromatosis has no relationship with superficial hemo siderosis of CNS [2,3]. In our 2 cases too.…”

“…Clinical and experimental findings indicate that the deposition of hemosiderin is due to a chronical bleeding into CSF; a unique subarachnoid bleeding does not play any role in determining this illness [1][2][3]. Systemic hemo chromatosis has no relationship with superficial hemo siderosis of CNS [2,3].…”

“…the diagnosis could only be suspected in life, based upon CSF and clinical findings, and could be confirmed only after autopsy [3]. With the support of MRI, a diagnostical tool for this condition in life is now available; hemosider in, due to its paramagnetic effect, can be easily depicted by this technique [4].…”

Cerebral Amyloid Angiopathy, Hemorrhages and Superficial Siderosis

“…Already in 1960, Iwanowski and Olszewski were able to experimentally reproduce SS in dogs by repeated subarachnoidal injections of blood. 2 In the review article from 1995 by Fearnly and colleagues, one can find a comprehensive summary of the issues regarding clinical, radiological and pathological findings observed in this entity. 3 In a more recent case report including a fine review of the literature, Levy and colleagues summarized the findings of the worldwide published reports (ie, 270 SS cases) and concluded that in only 3% of all reported SS cases was the etiology considered to be related to CAA.…”