“…However, the advantages of S. cerevisiae have allowed increased understanding of fungal polyketide pathways and biosynthesis (Tsunematsu et al, 2013). For example, of the polyketides in Figure 1, the lovastatin and brefeldin A biosynthetic pathways were identified using heterologous yeast expression (Barriuso et al, 2011; Ma et al, 2009; Zabala et al, 2014), and the effects of statins, brefeldin A, mycophenolic acid, and griseofulvin have all been studied in yeast (Athlin et al, 1987; Desmoucelles et al, 2002; Kuranda et al, 2010; Leszczynska et al, 2009; Maciejak et al, 2013; Shah and Klausner, 1993). Aflatoxin pathway genes have been expressed heterologously in yeast in order to study aflatoxin biosynthesis, and its mode of action has also been studied using yeast (Fasullo et al, 2008; Kelly et al, 2002; Yabe et al, 2012).…”