The Effects of Some Immunosuppressive Agents on Kidney Graft Survival in Rats

Wj, Tinbergen

doi:10.1097/00007890-196803000-00006

Cited by 23 publications

(3 citation statements)

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“…at the time of transplantation. Hydronephrosis remained more of a problem, and it would appear from the literature that the same degree of hydronephrosis has been an almost inevitable sequel to renal transplantation in the rat (Guttmann and others, 1967;Feldman and Lee, 1967;Sakai and others, 1968;Tinbergen, 1968).…”

Section: Resultsmentioning

confidence: 99%

Renal transplantation in the rat

Salaman

1969

British Journal of Surgery

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Section: Resultsmentioning

confidence: 99%

Renal transplantation in the rat

Salaman

1969

British Journal of Surgery

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“…As the infusioncatheters clogged to an unacceptable degree when used longer than 4 weeks, statistically usable survival data from methylprednisolone administration by continuous infusion could only be obtained with smaller, less immunosuppressive doses. A dose of 10 mgkg per day given every 12 h was moderately effective in prolonging transplant survival. However, despite a strong histocompatibility barrier, a continuous infusion of this daily methylprednisolone dose created a threefold increase in FST.…”

Section: Discussionmentioning

confidence: 96%

The influence of dose interval on the immunosuppressive potency of methylprednisolone: an experimental organ transplant study in isogenous rats

Husberg

Konrad

1990

Transplant Int

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Groups of isogenous Brown-Norway rats received heterotopic heart transplants from (Brown-Norway/Wistar Furth) x F1 hybrid rats. Methylprednisolone was administered IV in a daily dose of 5-40 mg/kg, using a dose interval of 24, 12, or 0 h (continuous infusion). Continuous infusion proved to be superior when small daily doses were used and then caused a more than threefold increase in graft survival. High daily doses created a substantial mortality with all dose intervals. Moreover, the equipment used for continuous drug administrations was unreliable beyond 4 weeks of infusion.

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“…36,37 The donor bladder cuff is anastomosed end-to-end to the dome of the recipient bladder after excising a cuff. A full thickness end-toend anastomosis is carried out by using continuous 6/0 Vicryl sutures.…”

Section: Bladder Cuffmentioning

confidence: 99%

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Shrestha

Haylor²

2017

Exp Clin Transplant

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Microvascular surgical techniques of renal transplant in rats have evolved over the past 5 decades to achieve successful rat renal transplant; these modifications have included surgical techniques to address the anatomic variations in the renal blood vessels and those to reduce ischemic and operation durations. Here, we review the surgical techniques of renal transplant in rats and evaluate the advantages and disadvantages of individual techniques of vascular and ureteric anastomoses. For this review, we performed a systematic literature search using relevant medical subject heading terms and included appropriate publications in the review. Since the first description of a rat model of renal transplant by Bernard Fisher and his colleagues in 1965, which used end-to-side anastomosis between the renal vein and renal artery to the recipient inferior vena cava and aorta, several vascular and ureteric anastomosis techniques have been modified. Vascular anastomosis techniques now include end-to-end anastomosis, use of donor aortic and inferior vena cava conduits, sleeve and cuff anastomoses, and application of fibrin glue. Likewise, restoration of the urinary tract can now be achieved by direct anastomosis of the donor ureter to the recipient bladder, end-to-end anastomosis between the donor and recipient ureters, and donor bladder cuff to the recipient bladder. There are advantages and disadvantages attributable to individual techniques. The range of vascular and ureteric anastomosis techniques that has emerged reflects the need for mastering more than one technique to suit the vascular anatomy of individual animals and to reduce operating time for achieving successful outcomes after renal transplant.

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The Effects of Some Immunosuppressive Agents on Kidney Graft Survival in Rats

Cited by 23 publications

References 0 publications

Renal transplantation in the rat

Renal transplantation in the rat

The influence of dose interval on the immunosuppressive potency of methylprednisolone: an experimental organ transplant study in isogenous rats

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