The effects of some essential and toxic metals/metalloids in COVID-19: A review

Domingo, José L.; Marquès, Montse

doi:10.1016/j.fct.2021.112161

Cited by 40 publications

(29 citation statements)

References 95 publications

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“…Recent studies have demonstrated the efficiency of selenium supplementation in viral infections such as polio, influenza, HIV, hantavirus, and SARS-CoV [14,47,48]. The decreased level of selenium among COVID-19 patients and its association with severity and mortality of disease may suggest the application of selenium supplementation for COVID-19 cases, but it has not been proven yet in large-scale clinical trials [4,11,49]. There is a narrow range between an appropriate and a toxic amount of this metalloid, so selenium supplements should be taken with caution [50].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 and Selenium Deficiency: a Systematic Review

Fakhrolmobasheri

Mazaheri‐Tehrani

Kieliszek

et al. 2021

Biol Trace Elem Res

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Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and in the case of COVID-19, several studies have reported heterogeneous results concerning the association of selenium deficiency with the severity of disease. To summarize the available data surrounding the association of body selenium levels with the outcomes of COVID-19, a systematic search was performed in the Medline database (PubMed), Scopus, Cochrane Library, Embase, and Web of Science using keywords including “SARS-CoV-2,” “COVID-19,” and “selenium,” Studies evaluating the association of COVID-19 with body selenium levels were included. Among 1,862 articles viewed in the database search, 10 articles were included after title, abstract, and full-text review. One study was further included after searching the literature again for any newly published articles. Out of 11 included studies, 10 studies measured serum selenium level, and one study investigated urinary selenium level. Three of 10 studies measured serum SELENOP level as well as selenium level. Glutathione peroxidase-3 level in serum was also assessed in one study. The reported outcomes were severity, mortality, and risk of COVID-19. Nine studies indicated that a lower serum selenium level is associated with worse outcomes. Two studies reported no significant association between serum selenium level and COVID-19. In one study, urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients, respectively. In most cases, selenium deficiency was associated with worse outcomes, and selenium levels in COVID-19 patients were lower than in healthy individuals. Thus, it could be concluded that cautious selenium supplementation in COVID-19 patients may be helpful to prevent disease progression. However, randomized clinical trials are needed to confirm this.

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Section: Discussionmentioning

confidence: 99%

COVID-19 and Selenium Deficiency: a Systematic Review

Fakhrolmobasheri

Mazaheri‐Tehrani

Kieliszek

et al. 2021

Biol Trace Elem Res

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“…With a lack of some trace elements, human immunity decreases, in the case of compensation with heavy metals, a negative effect on the body is also observed. The current SARS-CoV-2/COVID-19 epidemic has had a significant impact on the health of citizens (Domingo & Marquès, 2021 ). Consideration should be given to the role of metals and metalloids in the treatment of this disease.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Ecotoxicity of Pollution by Potentially Toxic Elements by Biological Indicators of Haplic Chernozem of Southern Russia (Rostov region)

Колесников

Minnikova

Казеев

et al. 2022

Water Air Soil Pollut

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The content of various chemical elements such as metals, metalloids, and nonmetals in the environment is associated with natural and anthropogenic sources. It is necessary to normalize the content of metals, metalloids, and nonmetals as potentially toxic elements (PTE) in the Haplic Chernozem. The soils of the Southern Russia are of high quality and fertility. However, this type of soil, like Haplic Chernozem, is subject to contamination with a wide range of PTE. The aim of the work was to rank metals, metalloids, and nonmetals by ecotoxicity in Haplic Chernozem. To assess the ecotoxicity of chernozem, data for 15 years (2005–2020) were used. Biological indicators used to assess the ecotoxicity of Haplic Chernozem: catalase activity, cellulolytic activity, number of bacteria, Azotobacter spp. abundance, to change of length of radish’s roots. Based on these biological indicators, an integral indicator of the state of Haplic Chernozem was calculated. The ecotoxicity of 23 metals (Cd, Hg, Pb, Cr, Cu, Zn, Ni, Co, Mo, Mn, Ba, Sr, Sn, V, W, Ag, Bi, Ga, Nb, Sc, Tl, Y, Yb), 5 metalloids (B, As, Ge, Sb, Te) and 2 nonmetals (F, Se) as priority pollutants. It is proposed to distinguish three hazard classes of metals, metalloids, and nonmetals to Haplic Chernozem: I class — Te, Ag, Se, Cr, Bi, Ge, Sn, Tl, Hg, Yb, W, Cd; II class — As, Co, Sc, Sb, Cu, Ni, B, Nb, Pb, Ga; III class — Sr, Y, Mo, Zn, V, Ba, Mn, F. It is advisable to use the results of the study for predictive assessment of the impact of metals, metalloids, and nonmetals on the ecological state of the soil during pollution.

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“…As one of the trace elements, cobalt is closely associated with human health [6]. Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element.…”

Section: Introductionmentioning

confidence: 99%

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

et al. 2021

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Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element. Current cancer treatment strategies, including chemotherapy and radiotherapy, have been seriously restricted by their side effects and low efficiency for a long time, which urges us to develop new technologies for more effective and much safer anticancer therapies. Novel nanotechnologies, based on different kinds of functional nanomaterials, have been proved to act as effective and promising strategies for anticancer treatment. Based on the important biological roles of cobalt, cobalt oxide nanoparticles (NPs) have been widely developed for their attractive biomedical applications, especially their potential for anticancer treatments due to their selective inhibition of cancer cells. Thus, more and more attention has been attracted to the preparation, characterization and anticancer investigation of cobalt oxide nanoparticles in recent years, which is expected to introduce novel anticancer treatment strategies. In this review, we summarize the synthesis methods of cobalt oxide nanoparticles to discuss the advantages and restrictions for their preparation. Moreover, we emphatically discuss the anticancer functions of cobalt oxide nanoparticles as well as their underlying mechanisms to promote the development of cobalt oxide nanoparticles for anticancer treatments, which might finally benefit the current anticancer therapeutics based on functional cobalt oxide nanoparticles.

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The effects of some essential and toxic metals/metalloids in COVID-19: A review

Cited by 40 publications

References 95 publications

COVID-19 and Selenium Deficiency: a Systematic Review

COVID-19 and Selenium Deficiency: a Systematic Review

Assessment of the Ecotoxicity of Pollution by Potentially Toxic Elements by Biological Indicators of Haplic Chernozem of Southern Russia (Rostov region)

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

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