The Effects of Some Anticholinergic Compounds on the Rabbit Ureter

Sjögren, Christer; Ulmsten, Ulf

doi:10.3109/00365597709179708

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Actions of acetylcholine on the dog ureteral move ments have been confused [8,9,14], In the present study, acetylcholine exhibited a tendency to decrease frequency and tension of the spontaneous contractions at lower con centrations and to increase them at a high concentration, which were not affected by atropine, phentolamine and hexamethonium. This result indicates the possibility that acetylcholine may directly act on ureteral smooth muscle.…”

Section: Discussionsupporting

confidence: 50%

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

et al. 1984

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Effects of some autonomic drugs on the isolated dog ureteral preparations showing spontaneous contractions were investigated quantitatively. Noradrenaline, adrenaline and phenylephnne produced increases in frequency and tension of the contractions which were reversed to decreases or depressed by phentolamine. Isoproterenol abolished the spontaneous contractions. Acetylcholine did not significantly change frequency and tension of the contractions. The results indicate that ureteral spontaneous contractions may be enhanced through an activation of Α-adrenoceptors and be attenuated through an activation of Β-adrenoceptors. However, acetylcholine will not display an important role on the ureteral contractions.

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Section: Discussionsupporting

confidence: 50%

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

et al. 1984

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Pharmacological effect on pyeloureteric dynamics with a clinical perspective: a review of the literature

et al. 2006

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We searched to review experimental and clinical trials concerning the capabilities of impacting on the ureteric and pelvic activity by means of pharmacological stimulation. Ureteropyeloscopy may cause high renal pelvic pressure. The normal pressure is in the range of 5-15 mmHg whereas pressure of 410 mmHg has been measured during endoscopy. The threshold pressure for intrarenal reflux is about 35 mmHg. Studies in animals have revealed that high renal pelvic pressures may cause permanent damage to the renal parenchyma. Furthermore, it has been demonstrated that elevated pressures may entail an increased risk of several complications related to endourological procedures including bleeding, perforation and infection. In other words, means by which intrarenal pressure could be lowered during endourological procedures might be beneficial with respect to clinical outcomes. In vitro experiments support the existence of different receptors in the ureter and renal pelvis. The ureteric and pelvic responses to the corresponding neurotransmitters have been determined. It seems that alpha-adrenergic and cholinergic agents are stimulating whereas beta-adrenergic agents inhibit ureteric activity. The effect may depend on the mode of administration. Drugs exerting advantageous effects in the pyeloureter may cause undesirable systemic side effects when administered intravenously. In animal studies, renal pelvic pressure can be significantly lowered by topical administration of beta-adrenergic agonists without systemic side effects. In vivo human studies are necessary to clarify the exact dose-response relationship and the degree of urothelial absorption of a drug before clinical use may be adopted.

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The Effects of Some Anticholinergic Compounds on the Rabbit Ureter

Cited by 2 publications

References 16 publications

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

Actions of Some Autonomic Drugs on Spontaneous Contractions of Isolated Dog Ureter

Pharmacological effect on pyeloureteric dynamics with a clinical perspective: a review of the literature

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