The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid Carriers

Apostolou, Maria; Assi, Sulaf; Fatokun, Amos A.; Khan, Iftikhar

doi:10.1016/j.xphs.2021.04.012

Cited by 39 publications

(29 citation statements)

References 113 publications

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“…3 A). As mentioned earlier the main goal of the production of NLCs as the second generation of SLNs is to increase drug loading and encapsulation by the addition of a liquid lipid which creates less ordered crystal lattice resulting in more voids and deformations which accommodate a higher percentage of the drug ( Apostolou et al, 2021 ). Thus increasing solid lipid amount in NLCs will subsequently decrease EE%.…”

Section: Resultsmentioning

confidence: 99%

Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utilizing radioiodinated zopiclone

Taha

Nour

Mamdouh

et al. 2023

International Journal of Pharmaceutics: X

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Section: Resultsmentioning

confidence: 99%

Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utilizing radioiodinated zopiclone

Taha

Nour

Mamdouh

et al. 2023

International Journal of Pharmaceutics: X

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“…Apostoloure et al reported that the particle size of SLNs depended on the structure and melting point of the solid lipids. Smaller particle sizes resulted from lower molecular weight (MW) molecules with simple conformations rather than from higher MW molecules with more complex conformations [ 24 ]. In the present study, the particle sizes of SLNs were smaller for TLR (MW = 639) than for TPT (MW = 807.33).…”

Section: Resultsmentioning

confidence: 99%

New Approach for Preparing Solid Lipid Nanoparticles with Volatile Oil-Loaded Quercetin Using the Phase-Inversion Temperature Method

et al. 2022

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Quercetin (QCT), a natural flavonoid, is of research interest owing to its pharmacological properties. However, its pharmacokinetic limitations could hinder its widespread therapeutic use. Nanocarriers, especially solid lipid nanoparticles (SLNs), might overcome this constraint. This study aimed to investigate QCT-loaded SLNs prepared via a new approach using a volatile oil. The phase-inversion temperature method was used to incorporate rosemary oil (RMO) into SLNs prepared using solid lipids possessing different chemical structures. Among the solid lipids used in the formulations, trilaurin (TLR) exhibited the smallest particle size and good stability after a temperature cycling test. SLNs prepared with a ratio of RMO to TLR of 1:3 could load QCT with an entrapment efficiency of >60% and drug loading of ~2% w/w. The smallest particle size was achieved using the polyoxyethylene-hydrogenated castor oil RH40, and the particle size depended on the concentration. The drug-release profile of QCT_TLR exhibited prolonged biphasic release for >24 h. QCT_TLR was a safe formulation, as indicated by a cell viability percentage of >75% at <2% v/v. In a computer simulation, the system with RMO enabled smaller sized SLNs than those without RMO. This new discovery shows great promise for producing SLNs via the phase-inversion temperature method with incorporation of volatile oil, particularly for delivering compounds with limited water solubility.

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“…According to Pornputtapitak (2019), the high liquid lipid content in NLC can reduce the viscosity in the NLC, resulting in small particles size caused by low surface tension. In addition, according to Apostolou et al, 2021, with increasing liquid lipid concentration, PS will decrease. It can also be attributed to the higher amount of solid lipids than liquid lipids in an NLC constituent formula which can affect the melting process and form agglomerates during NLC production.…”

Section: Measurement Results Of Particle Size (Ps) and Polydispersity...mentioning

confidence: 99%

Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid

Suryawijaya

Purwanti

Purwanto

et al. 2022

JFIKI

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Background: Green tea extract is a hydrophilic antioxidant that is difficult to penetrate. A nanostructured lipid carrier (NLC) delivers a system consisting of solid-liquid lipids that can improve penetration. Argan oil is a vegetable oil that can be used as a liquid lipid in NLC, reducing particle size and increasing penetration by hydrating the skin. Objective: To determine the formula of NLC green tea extract (NLC-GTE) with liquid lipid argan oil, which has good characteristics and is stable. Methods: Preparation of NLC-GTE used the High Shear Homogenization with solid lipids (cetyl palmitate-glyceryl stearate) - liquid lipids (argan oil) NLC-GTE1 (50:50), NLC-GTE2 (70:30), and NLC-GTE3 (90:10). Characteristic tests included organoleptic, pH, particle size (PS), and polydispersity index (PI). The physical stability test (organoleptic, pH, PS, and PI) used the thermal cycling method (3 cycles six days). Result: NLC-GTE1 – NLC-GTE2 has an odor of argan oil. NLC-GTE3 has odorless. NLC-GTE1 – NLC-GTE3 has a pH scale from 5.782-5.784; PS ranges from 359.73–432.56 nm; PI ranges from 0.175-0.257. The statistical analysis results showed no significant difference between NLC-GTE1 – NLC-GTE3 in pH and PI, there was a significant difference in PS NLC-GTE1; NLC-GTE2 against NLC-GTE3. Physical stability test NLC-GTE2 – NLC-GTE3 phase separation occurs. The statistical analysis results showed no significant difference in pH values NLC-GTE1 – NLC-GTE3 before and after storage; there was a significant difference in NLC-GTE3 before and after storage. Conclusion: NLC-GTE1 was a formula with good characteristics and stability.

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The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid Carriers

Cited by 39 publications

References 113 publications

Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utilizing radioiodinated zopiclone

Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utilizing radioiodinated zopiclone

New Approach for Preparing Solid Lipid Nanoparticles with Volatile Oil-Loaded Quercetin Using the Phase-Inversion Temperature Method

Characteristic and Physical Stability of Anti-Aging Green Tea Extract (GTE) on NLC with Argan Oil as Liquid Lipid

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