Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity &amp; in vivo biodistribution utilizing radioiodinated zopiclone

Taha, Esraa; Nour, Samia A.; Mamdouh, Wael; Selim, Adli A.; Swidan, Mohamed M.; Ibrahim, A. B.; Naguib, Marianne J.

doi:10.1016/j.ijpx.2023.100160

Cited by 7 publications

(6 citation statements)

References 113 publications

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“…High surfactant concentration was illustrated to decrease surface tension, thereby stabilising the surface during homogenisation and preventing particle agglomeration which in turn leads to the production of smaller particle size [ 60 , 61 ]. Kim et al [ 58 ] and Taha et al [ 62 ] also reported similar findings. Sonication time showed biphasic responses indicating optimal sonication time was required to produce particles of the desired size as illustrated in Fig.…”

Section: Resultssupporting

confidence: 60%

Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery

Abdella,

Kim,

Afinjuomo

et al. 2023

Drug Deliv. and Transl. Res.

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Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and low oral bioavailability. To overcome the challenges associated with CBD delivery, we employed Design of Experiments (DoE), lipid carriers, and 3D printing techniques to optimize and develop buccal film loaded with CBD-NLCs. Three-factor Box-Behnken Design was carried out to optimise the NLCs and analyse the effect of independent factors on dependent factors. The emulsification-ultrasonication technique was used to prepare the NLCs. A pressure-assisted micro-syringe printing technique was used to produce the films. The produced films were studied for physicochemical, and mechanical properties, release profiles, and predicted in vivo performance. The observed particle size of the NLCs ranged from 12.17 to 84.91 nm whereas the PDI varied from 0.099 to 0.298. Lipid and sonication time positively affected the particle size whereas the surfactant concentration was inversely related. CBD was incorporated into the optimal formulation and the observed particle size, PDI, and zeta potential for the CBD-NLCs were 94.2 ± 0.47 nm, 0.11 ± 0.01 and − 11.8 ± 0.52 mV. Hydroxyethyl cellulose (HEC)-based gel containing the CBD-NLCs was prepared and used as a feed for 3D printing. The CBD-NLCs film demonstrated a slow and sustained in vitro release profile (84. 11 ± 7.02% in 6 h). The predicted AUC0–10 h, Cmax, and Tmax were 201.5 µg·h/L, 0.74 µg/L, and 1.28 h for a film with 0.4 mg of CBD, respectively. The finding demonstrates that a buccal film of CBD-NLCs can be fabricated using 3D printing. Graphical Abstract

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Section: Resultssupporting

confidence: 60%

Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery

Abdella,

Kim,

Afinjuomo

et al. 2023

Drug Deliv. and Transl. Res.

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“…organ (contralateral muscle). 46,70,71,76 Throughout the whole experiment duration, the data showed positive T/NT values, with a magnitude value of 17.5 at 1 h p.i. (Fig.…”

Section: In Vivo Biodistribution Evaluationmentioning

confidence: 92%

“…As a key tactic for determining the pharmacokinetic characteristics connected to any recently established theranostic platforms, the in vivo distribution studies are at the leading edge of this approach. 46,70,71 Consequently, two distinct experimental mouse groups were used to examine the biodistribution pattern of 99m Tc-labeled DOX-loaded ZnO@dextran. Upon administering 99m Tc-labeled DOX-loaded ZnO@dextran intravenously to healthy mice, the in vivo distribution profile displayed the conventional biodistribution pattern of functionalized nanomaterials.…”

Section: In Vivo Biodistribution Evaluationmentioning

confidence: 99%

pH-Sensitive doxorubicin delivery using zinc oxide nanoparticles as a rectified theranostic platform: in vitro anti-proliferative, apoptotic, cell cycle arrest and in vivo radio-distribution studies

Swidan,

Marzook,

Sakr

2024

J. Mater. Chem. B

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“…Synthesis of radioiodinated compound 4Radioactive iodine (I-131) was electrophilically introduced in compound 4 by using chloramine-T which oxidize [ 131 I]iodide to [ 131 I]iodonium form 49,50 . The radiolabeling process was carried out through the optimization of different parameters: Chloramine-T: from 100 to 600 µg, pH: from 4 to 9, Compound 4 content: from 100 to 600 µg, and Reaction time: from 15 min to 24 h. Radioiodinated compound 4 formation was calculated by chromatographic technique using paper chromatography and TLC to evaluate the highest radiochemical purity.…”

Section: Radiosynthesis and In-vivo Biodistribution Of Radioiodinated...mentioning

confidence: 99%

Novel pyridine bearing pentose moiety-based anticancer agents: design, synthesis, radioiodination and bioassessments

Mehany,

Hammam,

Selim

et al. 2024

Sci Rep

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Pyridine compounds are one of the most important heterocyclic derivatives showing wide ranges in biological and pharmacological activities. Green chemistry eliminates or reduces the generation of hazardous compounds. It prevents pollution at a molecular level. The microwave technique used in heterocyclic compound synthesis is also an important branch of green chemistry techniques. In this study, we report designing and synthesizing a new pyridine-bearing pentose moiety via a one-pot multicomponent reaction using D-glucose and also investigate its behavior and reactivity toward some simple and heterocyclic amino derivatives. The chemical structures of the synthesized compounds were characterized and tested for their cytotoxic activities. Some of the test compounds exhibited slight to high cytotoxic activities against Caco2 (colon cancer) cells, HepG2 (hepatocellular carcinoma) cells and MCF-7 (human breast cancer) cells by MTT assay. The results showed clearly that compound 4 and compound 8 displayed strongest to moderate cytotoxic activity against the HepG2, Caco2 and MCF-7 respectively and compound 1 showed good activity against MCF-7 in comparison to the standard anticancer drug doxorubicin. These data were by cytopathological examination. An in-vivo radioactive tracing study of compound 4 proved its targeting ability to sarcoma cells in a tumor-bearing mice model. Our findings suggest that the synthesized compounds may be promising candidates as novel anticancer agents.

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Cod liver oil nano-structured lipid carriers (Cod-NLCs) as a promising platform for nose to brain delivery: Preparation, in vitro optimization, ex vivo cytotoxicity & in vivo biodistribution utilizing radioiodinated zopiclone

Cited by 7 publications

References 113 publications

Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery

Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery

pH-Sensitive doxorubicin delivery using zinc oxide nanoparticles as a rectified theranostic platform: in vitro anti-proliferative, apoptotic, cell cycle arrest and in vivo radio-distribution studies

Novel pyridine bearing pentose moiety-based anticancer agents: design, synthesis, radioiodination and bioassessments

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