The Effects of Sodium Fluoride on Calcium Metabolism of Subjects with Metabolic Bone Diseases*

Rich, Charles L.; Ensinck, John W.; Ivanovich, Peter

doi:10.1172/jci104940

Cited by 134 publications

(9 citation statements)

References 16 publications

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“…Earlier, gastrointestinal symptoms were reported in 39% 30 31 of the patients treated with NaF. However, gastrointestinal side effects occur less frequently when enteric coated sodium fluoride tablets are used 32. In this study, none of the 23 NaF treated patients reported gastrointestinal complaints.…”

Section: Discussionmentioning

confidence: 45%

Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis?

Lems

Jacobs

Bijlsma

et al. 1997

Annals of the Rheumatic Diseases

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Objective-To investigate whether administration of sodium fluoride (NaF) in addition to cyclical etidronate has a positive eVect on bone mineral density (BMD) in patients with established osteoporosis during continued treatment with corticosteroids. Patients and methods-47 patients who were receiving treatment with corticosteroids were included in a two year randomised, double blind, placebo controlled trial. Established osteoporosis was defined as a history of a peripheral fracture or a vertebral deformity, or both, on a radiograph. All patients were treated with cyclical etidronate, calcium, and either NaF (25 twice daily) or placebo. Vitamin D was supplemented in the case of a low serum 25 (OH) vitamin D concentration. BMD of the lumbar spine and hips was measured at baseline and at 6, 12, 18, and 24 months. Results-After two years of treatment, the BMD of the lumbar spine in the etidronate/NaF group had increased by +9.3% (95% confidence intervals (CI): +2.3% to +16.2%, p<0.01), while the BMD in the etidronate/placebo group was unchanged: +0.3% (95% CI: −2.2% to +2.8%). The diVerence in the change in BMD between groups was +8.9% (95% CI: +1.9% to +16.0%, p<0.01). For the hips, no significant changes in BMD were observed in the etidronate/NaF group after two years: −2.5% (95% CI: −6.8% to +1.8%); in the etidronate/placebo group BMD had significantly decreased: −4.0% (95% CI: −6.6% to −1.4%; p<0.01). The diVerence between the groups was not significant: +1.5% (95% CI: −3.4% to +6.4%). No significant diVerences in number of vertebral deformities and peripheral fractures were observed between the two groups. Conclusion-The eVect of combination treatment with NaF and etidronate on the BMD of the lumbar spine in corticosteroid treated patients with established osteoporosis is superior to that of etidronate alone.

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Section: Discussionmentioning

confidence: 45%

Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis?

Lems

Jacobs

Bijlsma

et al. 1997

Annals of the Rheumatic Diseases

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“…All these findings are in accord with the opinion of most investigators that fluoride increases the mineralization rate of bones by reducing the excretion of calcium in both feces and urine. 4 5,21,26 Rich and Ensinck27 were able to convert negative calcium balances into positive ones by giving 60 mg. of NaF daily to human beings with osteoporosis or Paget's disease.…”

Section: Resultsmentioning

confidence: 99%

Effect of Fluoride on Hypervitaminosis D in Rats

Gedalia

Binderman

1966

J Dent Res

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SYNOPSIS IN INTERLINGUA LE EFFECTO DE FLUORURO SUPER HYPERVITAMINOSIS D IN RATTOS.-Esseva usate rattos recipients 0,2 mg de fluoruro per die (i.e., approximativemente le ingestion physiologic pro le ratto), rattos recipients doses toxic de vitamina D, rattos recipients vitamina D e fluoruro simultaneemente, e rattos de control. Esseva effectuate determinationes de calcium in le sero e le urina e del gravitate specific e del contento de cinere in le femure si hen como su contento de calcium. Le resultatos revelava que fluoruro age contra le syndrome de hypervitaminosis D per reducer usque ad valores quasi normal le concentrationes de calcium in le sero e le urina e etiam que illo preveni le resorption de osso. Es suggestionate que in hypervitaminosis D, le presentia de un augmentate concentration de iones de fluoruro in le liquidos del tissus induce un precipitation de fluoro-apatite.The toxic effects of excessive amounts of vitamin D on rats have been studied by many investigators. The main effects found were an increased rate of bone resorption, accompanied by hypercalcemia and histologic changes in bones and teeth.'-3It has often been stated that increased fluoride (F) intake hypermineralizes preformed bone.4 Some investigators were able to reduce the toxic effects produced by high doses of fluoride in rats by administering vitamin D in amounts greater than the normal physiologic requirement.5The purpose of this study was to investigate the effect of fluoride administration in hypervitaminosis D. Materials and MethodsForty-two male and female rats of the Sabra strain (Hebrew University), weighing 170 + 20 Gm., were used. They were maintained on a standard mixed diet containing 3.2 ppm F and were provided with drinking water containing 0.5 to 0.6 ppm of F. This diet is considered to be low in fluoride for rats.7 The rats were allotted to 6 groups ( Table 1): Group 1-4 rats were used as controls. Group 2-10 rats each received 500,000 USP units of vitamin D2 (12.5 mg.) daily, in a single subcutaneous dose for 4 consecutive days. Group 3-6 rats each received 1 ml. of 0.04 per cent NaF solution (0.2 mg. of F) intraperitoneally, daily, for 4 consecutive

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“…Thus, it appears that fluoride in a concentration between 4 and 6 ppm has significantly decreased the incidence of osteoporosis when compared to a similar population consuming less than 0.3 ppm. In addition, this study suggests that fluoride has a protective effect on the blood vessels, at least in preventing calcification of the aorta.…”

Section: Vivisection-vivistudy: the Facts And The Benefits To Animal mentioning

confidence: 91%

I. The contribution of animal studies to nutritional discoveries that have benefited both animals and man.

McCann¹,

Stare²

1967

Am J Public Health Nations Health

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The Effects of Sodium Fluoride on Calcium Metabolism of Subjects with Metabolic Bone Diseases*

Cited by 134 publications

References 16 publications

Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis?

Is addition of sodium fluoride to cyclical etidronate beneficial in the treatment of corticosteroid induced osteoporosis?

Effect of Fluoride on Hypervitaminosis D in Rats

I. The contribution of animal studies to nutritional discoveries that have benefited both animals and man.

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