The effects of sitosterol on serum lipids

Best, Maurice M.; Duncan, Charles H.; Loon, Edward J. Van; Wathen, Joan D.

doi:10.1016/0002-9343(55)90274-6

Cited by 88 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical results we have observed are comparable to those reported by four other investigators 8,9,10,11,12 who conducted similar doubleblind studies using the same preparations.…”

Section: --+-F+-------;;-;----------pi--\-------c;------supporting

confidence: 90%

SECTION OF BIOLOGY: SYMPOSIUM ON SITOSTEROL I. THE EFFECTS OF SITOSTEROL INGESTION ON SERUM CHOLESTEROL CONCENTRATION*

Shipley¹

1955

Trans NY Acad Sci

View full text Add to dashboard Cite

“…The clinical results we have observed are comparable to those reported by four other investigators 8,9,10,11,12 who conducted similar doubleblind studies using the same preparations.…”

Section: --+-F+-------;;-;----------pi--\-------c;------supporting

confidence: 90%

SECTION OF BIOLOGY: SYMPOSIUM ON SITOSTEROL I. THE EFFECTS OF SITOSTEROL INGESTION ON SERUM CHOLESTEROL CONCENTRATION*

Shipley¹

1955

Trans NY Acad Sci

View full text Add to dashboard Cite

“…3 The lack of any effect on triglycérides is in conflict with the reduction reported in the earlier study in which triglycérides (neutral fat) were estimated by an indirect method. That this conflict is due to inaccu¬ racy of the indirect triglycéride estimation rather than to any difference in the response of diabetic and nondiabetic patients is indicated by a lack of effect of sitosterol on serum triglycérides of several nondiabetics recently observed.…”

Section: Commentmentioning

confidence: 73%

Effects of Cholesterol-Lowering Drugs on Serum Triglycerides

Best¹,

Duncan²

1964

JAMA

Self Cite

View full text Add to dashboard Cite

“…Daily administration of β-sitosterol at a dose of 25 mg for a prolonged time in patients was able to reduce serum total cholesterol with a reduction of serum total lipids (Best et al 1955). …”

Section: Bio-assay Guided Purification and Structural Elucidation Of mentioning

confidence: 99%

Effect of Thevetia Peruviana on Murine-Induced Obesity

Pérez-García¹,

Romero-Cerecero²,

Zamilpa³

et al. 2017

Afr J Tradit Complement Altern Med

View full text Add to dashboard Cite

Background: Obesity is considered a multifactorial disease that has importantly increased the development of chronic degenerative diseases. Drugs available for treating obesity have the inconvenience of producing side effects of importance. In Mexican traditional medicine, the seeds of Thevetia peruviana have been widely employed for weight reduction. Materials and Methods:The effect produced by different extracts of T. peruviana on MonoSodium Glutamate (MSG)-induced obesity in mice was evaluated. A chemical analysis oriented toward the identification of the chemical compounds contained in the active extract was carried out. Results: Oral administration of the hexanic extract of T. peruviana (for 7 weeks) was capable of diminishing weight gain by up to 24.1% in the mice without observing the development of resistance to insulin. Median lethal dose of the hexanic and Ethyl Acetate (EtOAc) extracts was >2 g/kg. By utilizing bio-assay guided fractionation, eight secondary metabolites were purified and characterized. Conclusion: The hexanic extract obtained from Thevetia peruviana seeds was capable of reducing weight gain in mice with induced obesity. In addition, this extract showed good response to the glucose tolerance test, was able to avoid the development of insulin resistance, and also substantially increased serum adiponectin levels. Eight low-polarity compounds were identified in the active fraction. This species could be considered for ongoing investigation as a potential option to reduce obesity

show abstract

The effects of sitosterol on serum lipids

Cited by 88 publications

References 10 publications

SECTION OF BIOLOGY: SYMPOSIUM ON SITOSTEROL I. THE EFFECTS OF SITOSTEROL INGESTION ON SERUM CHOLESTEROL CONCENTRATION*

SECTION OF BIOLOGY: SYMPOSIUM ON SITOSTEROL I. THE EFFECTS OF SITOSTEROL INGESTION ON SERUM CHOLESTEROL CONCENTRATION*

Effects of Cholesterol-Lowering Drugs on Serum Triglycerides

Effect of Thevetia Peruviana on Murine-Induced Obesity

Contact Info

Product

Resources

About