The effects of sitosterol on serum cholesterol, platelet economy, thrombogenesis and atherosclerosis in the rabbit

Murphy, Edmond A.; Rowsell, H. C.; Mustard, J. F.

doi:10.1016/0021-9150(73)90092-0

Cited by 15 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…B and C. If platelets from cholesterol-fed rabbits are younger than norm al they should survive longer than normal platelets, so that, when injected into a cholesterol-dam aged vasculature the net result could be a normal survival (when com pared to normal platelets injected into norm al animals). This phenom enon may also explain why a previous study did not find shortened survival in cholesterol-fed rabbits (34).…”

Section: Discussionmentioning

confidence: 87%

See 1 more Smart Citation

The Effect of Dietary Cholesterol on Platelet Survival in the Rabbit – A Study Using 14C-Serotonin and 51Chromium Double-Labelled Platelets

Wanless

1984

Thromb Haemost

View full text Add to dashboard Cite

SummaryHypercholesterolemic men and monkeys have shortened platelet survival but attempts to demonstrate this in rabbits have been unsuccessful. The present study examines platelet survival in cholesterol-fed rabbits. Platelets were double-labelled in vitro with 51Cr and 14C-serotonin or in vivo by intravenous injection of 14C-serotonin.In the double-label experiments 51Cr survival was always shorter than 14C survival but changes in survival of one label were accompanied by similar changes in the other label. Survival was shortened after 4 and 7 weeks of cholesterol feeding. This was demonstrated when the donor platelets were from normal rabbits for both cholesterol and control recipients but no shortening was demonstrated when cholesterol-rich platelets were injected into cholesterol-fed recipients and normal platelets were injected into the control rabbits. When 14C-serotonin was injected intravenously 14C survival was the same as when platelets were labelled ex vivo prior to injection and 14C survival was shortened in rabbits fed cholesterol for 1,2, and 6 weeks.These results indicate that cholesterol-feeding shortens platelet survival. This effect may be masked if the test platelets are not identical in both test and control groups.

show abstract

Section: Discussionmentioning

confidence: 87%

“…M urphy and M ustard found that platelet survival was shortened in men with hypercholesterolem ia (30). This was confirmed in men (25,31,32) and in monkeys (22,33) but not in rabbits (34).…”

Section: Discussionmentioning

confidence: 90%

The Effect of Dietary Cholesterol on Platelet Survival in the Rabbit – A Study Using 14C-Serotonin and 51Chromium Double-Labelled Platelets

Wanless

1984

Thromb Haemost

View full text Add to dashboard Cite

show abstract

“…According to Pollak (21), a six-fold excess of S over cholesterol was needed to entirely prevent the hypercholesterolemia in the rabbit induced by daily ingestion of 1g of dietary cholesterol and the extent of depression of cholesterol-induced hypercholesterolemia was proportional to the dosage of S. Murphy et al found that 100mg of cholesterol and 400mg of S per day completely inhibited the increase of serum cholesterol (22). Thus, the incompleteness in the lowering of serum choles terol in the present study can be attributed to a lower dosage of S or HS relative to cholesterol, the ratio of cholesterol to plant sterols (stanols) was 1:1 and 1:2.5 in Exps.…”

Section: Discussionmentioning

confidence: 99%