The effects of simvastatin and levothyroxine on intima-media thickness of the carotid artery in female normolipemic patients with subclinical hypothyroidism: a prospective, randomized-controlled study

Duman, Dursun; Demirtunç, Refik; Şahin, Sinan; Esertas, Kenan

doi:10.2459/jcm.0b013e3282f03bc1

Cited by 25 publications

(23 citation statements)

References 39 publications

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“…Moreover, SH decreases flow-mediated vasodilation and nitric oxide (NO) availability, which are markers of endothelial function [98, 99]. An increase in CIMT has also been described in SH patients compared with controls [78, 79]. However, a study in SH patients (n=21) did not confirm such an increase in CIMT compared with euthyroid subjects [100].…”

Section: Hypothyroidismmentioning

confidence: 99%

Effects of Thyroid Dysfunction on Lipid Profile

Rizos

Elisaf²,

Liberopoulos³

2011

TOCMJ

293

249

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Thyroid dysfunction has a great impact on lipids as well as a number of other cardiovascular risk factors. Hypothyroidism is relatively common and is associated with an unfavorable effect on lipids. Substitution therapy is beneficial for patients with overt hypothyroidism, improving lipid profile. However, whether subclinical hypothyroidism should be treated or not is a matter of debate. On the other hand, hyperthyroidism can be associated with acquired hypocholesterolemia or unexplained improvement of lipid profile. Overall, thyroid dysfunction should be taken into account when evaluating and treating dyslipidemic patients.

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Section: Hypothyroidismmentioning

confidence: 99%

Effects of Thyroid Dysfunction on Lipid Profile

Rizos

Elisaf²,

Liberopoulos³

2011

TOCMJ

293

249

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“…The lipid abnormalities in overt hypothyroidism are reversible with L-T4 therapy unless the patient has underlying hyperlipidemia [95]. SCH is associated with increased levels of TC and LDL-C [96][97][98][99]. In addition, some studies have shown that SCH-induced dyslipidemia may also be accompanied by increased TGs [100][101] and decreased HDL-C levels [102].…”

Section: *Correspondencementioning

confidence: 99%

Association of Diabetes Mellitus and Thyroid Disorders: A Metabolic Prospective

Mishra¹,

Relatado-Sotto²,

Panta³

et al. 2017

APJHS

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The prevalence of diabetes has nearly doubled since 1980, mounting from 4.7% to 8.5% in overall adult population. Thyroid disorder is another common endocrine disorder with prevalence of hypothyroidism as much as 4.6% and hyperthyroidism as much as 1.3% in population according to the National Health and Nutrition Examination Survey. These two most common endocrinopathies often co-exist and mutually influence each other. They have complex links of abnormal biochemical pathways, unregulated genetic expression of many genes and hormonal malfunctions. Thyroid hormones affects the regulation of carbohydrate metabolism, lipid metabolism and pancreatic function, and on the other hand, diabetes affects thyroid function tests to variable extents. In this review article we emphasized the epidemiology of diabetes and thyroid disorders, classification of thyroidism, and finally the impact of thyroidism to the various aspects of glucose and lipid metabolism in diabetics.

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“…Therefore, the cIMT reduction associated with levothyroxine replacement cannot be attributed to improved lipid parameters. 68 On the other hand, 1-year treatment with levothyroxine conferred no improvement in cIMT in women with SCH (n = 32), 67 but decelerated the deterioration in brachial artery flow-mediated dilatation (FMD), an effect also noted in the study group receiving no treatment. Moreover, there is additional evidence suggesting a beneficial effect of levothyroxine treatment on endothelial function in SCH.…”

mentioning

confidence: 98%

“…47, [67][68][69][70][71] Overall, it appears that the beneficial effect-if any-of levothyroxine treatment on lipid profile in SCH mainly concerns TC and LDL-C levels. TG concentrations are not significantly affected.…”

Section: Effect Of Levothyroxine Treatmentmentioning

confidence: 99%

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Subclinical hypothyroidism and vascular risk: Αn update

Lioudaki¹,

Mavroeidi²,

Mikhailidis³

et al. 2013

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subclinical hypothyroidism (scH), defined as elevated serum thyroid-stimulating hormone (tsH) in the presence of normal circulating free thyroxine (Ft4) and triiodothyronine (t3), is a relatively common condition. replacement treatment with levothyroxine is justified only for individuals with tsH levels >10 mIU/l. serum lipid levels are influenced by thyroid status and there is evidence pointing to a link between scH and an unfavorable lipid profile. Despite some conflicting data, most studies suggest that levothyroxine treatment may exert a beneficial effect on the lipid profile in scH regarding mainly total cholesterol and low-density lipoproteincholesterol. Moreover, it appears that treatment may also improve some other markers associated with cardiovascular (cV) disease such as carotid intima media thickness ( 17-03-201317-03- , Accepted 20-10-2013 Review (FT4) and triiodothyronine (T3) levels within the reference range.1 This is a relatively common condition with a prevalence ranging from 4 to 15% in the general population and up to 20% among females aged >60 years. [2][3][4][5]

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The effects of simvastatin and levothyroxine on intima-media thickness of the carotid artery in female normolipemic patients with subclinical hypothyroidism: a prospective, randomized-controlled study

Cited by 25 publications

References 39 publications

Effects of Thyroid Dysfunction on Lipid Profile

Effects of Thyroid Dysfunction on Lipid Profile

Association of Diabetes Mellitus and Thyroid Disorders: A Metabolic Prospective

Subclinical hypothyroidism and vascular risk: Αn update

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