Effects of Thyroid Dysfunction on Lipid Profile

Rizos, Christos V.; Elisaf, Moses; Liberopoulos, Evangelos N.

doi:10.2174/1874192401105010076

Cited by 309 publications

(309 citation statements)

References 146 publications

(208 reference statements)

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“…Serum HDL-C in the present study was nonsignificantly lower in hypothyroid patients compared to the controls, which is in agreement with previous studies (38,39). However, this finding differs from other studies (41,42), which reported a significant increase in serum HDL-C levels in hypothyroid patients.…”

Section: Discussionsupporting

confidence: 94%

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

2016

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Objectives: This study aimed to measure lipoprotein (a) [Lp(a)], lipid profile and mean platelet volume (MPV) in hypothyroid patients compared to healthy controls.Methods: An unmatched case-control study was conducted involving 100 subjects (50 overt hypothyroidism patients and 50 healthy controls admitted to the University of Science and Technology Hospital, Al-Thawra Hospital and Al-Jomhori Hospital-Sana'a, Yemen during the period from May 2013 to March 2014. Data were collected by in-person interview using a structured questionnaire followed by weight and height measurements. Fresh blood samples were collected and analyzed using electrochemiluminescent, spectrophotometric and immunoturbidimetric methods for estimating Lp(a), lipid profile and MPV parameters. Results:Hypothyroid patients had a significantly higher concentration of Lp(a) compared to the control. Total cholesterol (TC), triglycerides and low-density lipoprotein-cholesterol (LDL-C) levels were also significantly higher in hypothyroid patients. Serum level of free triiodothyronine (FT3) was negatively correlated with Lp(a), p=0.007; p=0.012; p=0.013, respectively). However, serum thyroid-stimulating hormone was positively correlated with Lp(a), p=0.015; r=0.299, p=0.035; r=0.405, p=0.004, respectively) among hypothyroid patients. MPV levels, on the other hand, showed a strong positive correlation with (r=0.611, p=0.001). Conclusions:These findings indicate that overt hypothyroidism patients tend to have increased Lp(a) and atherogenic lipids that may contribute to increasing risk of atherosclerosis. However, hypothyroid patients showed no significant difference compared to the controls regarding the MPV

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Section: Discussionsupporting

confidence: 94%

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

2016

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“…Elevated prolactin may result from untreated hypothyroidism because hypothalamic thyrotropin‐releasing hormone, which is commonly elevated in hypothyroidism, stimulates both prolactin synthesis and release from the pituitary 29. Hypothyroidism is associated with hypertension and elevations in HDL cholesterol 30, 31. Nevertheless, this mechanism is speculative.…”

Section: Discussionmentioning

confidence: 99%

Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study

Therkelsen

Abraham

Pedley

et al. 2016

JAHA

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BackgroundProlactin is an anterior pituitary hormone that may modulate the adverse effects of obesity. Prolactin has been associated with cardiovascular disease mortality, but less is known about whether prolactin predicts incidence of cardiovascular disease risk factors.Methods and ResultsOur sample (n=3232, mean age 40.4 years, 52.1% women) was drawn from Framingham Heart Study participants who attended 2 examinations an average of 6.1 years apart. After excluding those with elevated prolactin (>30 mg/dL for women, >20 mg/dL for men), multivariable‐adjusted regressions modeled the associations between baseline prolactin and changes in cardiovascular disease risk factors. Models were adjusted for age, sex, baseline value of the risk factor, smoking status, hormone replacement therapy, and menopausal status and additionally for body mass index. Mean prolactin levels were 11.9 mg/dL (SD 5.2) in women and 8.0 mg/dL (SD 2.9) in men. No associations were observed for change in weight, body composition, total cholesterol, triglycerides, or fasting glucose. In women, for example, for each 5‐mg/dL increment in prolactin, odds of incident hypercholesterolemia were 1.06, which was not significant (95% CI 0.91–1.23, P=0.46). Some exceptions were of note. In women, for each 5‐mg/dL increment in prolactin, we observed increased odds of low high‐density lipoprotein cholesterol at follow‐up (odds ratio 1.50, 95% CI 1.18–1.91, P=0.001) that persisted after adjustment for body mass index (P=0.001). In men, a 5‐mg/dL increment in prolactin was associated with increased odds of incident hypertension (odds ratio 1.61, 95% CI 1.18–2.20 P=0.002) and incident diabetes (odds ratio 1.70, 95% CI 1.04–2.78, P=0.03).ConclusionsProlactin is not associated with a comprehensive panel of incident cardiovascular disease risk factors. Measurement of circulating prolactin levels in the community likely does not provide substantial insight into cardiometabolic risk.

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“…9 The difference could be explained by our larger sample size of 50 individuals whereby the study in Tamil Nadu had a sample size of 30. have also reported similarly higher TG levels, but TC and LDL-C were also reported to be higher in SCH as in our study. 2,5 Contrary to all what is being said, an amazing result was presented in National Health Examination Survey III, in which 215 subjects with diagnosed SCH and 8013 Euthyroid individuals were checked for fasting lipid profile. Strangely no difference was found in the lipid profile picture of SCH and Euthyroid individuals.…”

Section: Discussionmentioning

confidence: 92%

“…10,28 In overt hypothyroidism also AIP levels have not been studied, but conflicting results were seen in studies investigating the impact of overt hypothyroidism on LDL-C subfractions, particularly LDL. 5 Though a recent study conducted on newly diagnosed hypothyroid patients showed an association between hypothyroidism and elevated LDL, other studies could not conclusively prove such an association. 29,30,31 All these results reiterate the need for studies on the association of fasting Lipid levels with SCH.…”

Section: Discussionmentioning

confidence: 97%

“…VLDL( Very low density Lipoprotein) LDL (Low Density Lipoprotein) TC (Total Cholesterol) and Triglycerides (TG) thereby predisposing individuals to vascular diseases. [3][4][5] However, the association of SCH with abnormalities in lipid parameters have been studied with conflicting results. 4,6 Some studies have also shown a link between SCH and metabolic syndrome while others have been unable to prove this.…”

mentioning

confidence: 99%

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Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

Zubair

Ijaz²,

Aftab³

2017

Annals KEMU

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A controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality. Methods:The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiarycare center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These were 1 Assistant Professor of Physiology

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Effects of Thyroid Dysfunction on Lipid Profile

Cited by 309 publications

References 146 publications

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

Lipoprotein (a), Lipid Profile and Mean Platelet Volume in Hypothyroid Patients in Sana'a, Yemen: A Case-Control Study

Association Between Prolactin and Incidence of Cardiovascular Risk Factors in the Framingham Heart Study

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

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