The effects of short-term contact lens-induced hypoxia tried on ourselves

Calossi, Antonio; Fossetti, Alessandro; Lupelli, Luigi; Rossetti, Anto

doi:10.1016/j.clae.2014.11.011

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventional hydrogel contact lenses are synthesized from hydrophilic monomers such as 2-hydroxyethyl methacrylate (HEMA), offering the wearer comfort due to their hydrophilicity. However, this class of contact lenses exhibits low oxygen permeability that may cause red-eye syndrome for long-term wearing [2,3]. To cope with this problem, silicon-containing polymers such as 3-(methacryloyloxy) propyltris(trimethylsiloxy) silane (TRIS) or polydimethylsiloxane (PDMS) are incorporated into the hydrogel to increase the oxygen permeability, leading to the inception of silicone hydrogel lenses [4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Ophthalmic Performance of Hydrogel Contact Lenses Loaded with Silicone Nanoparticles

Tran

Yang

2020

Polymers

View full text Add to dashboard Cite

In this study, silicone nanoparticles (SiNPs) were prepared from polydimethylsiloxane (PDMS) and tetraethyl orthosilicate (TEOS) via the sol-gel process. The resultant SiNPs were characterized by dynamic light scattering (DLS), transmission electron microscope (TEM), and scanning electron microscope (SEM). These SiNPs were then blended with 2-hydroxyethylmethacrylate (HEMA) and 1-vinyl-2-pyrrolidinone (NVP) before polymerizing into hydrogel contact lenses. All hydrogels were subject to characterization, including equilibrium water content (EWC), contact angle, and oxygen permeability (Dk). The average diameter of SiNPs was 330 nm. The results indicated that, with the increase of SiNPs content, the oxygen permeability increased, while the EWC was affected insignificantly. The maximum oxygen permeability attained was 71 barrer for HEMA-NVP lens containing 1.2 wt% of SiNPs with an EWC of 73%. These results demonstrate that by loading a small amount of SiNPs, the Dk of conventional hydrogel lenses can be improved greatly. This approach would be a new method to produce oxygen-permeable contact lenses.

show abstract