The Ophthalmic Performance of Hydrogel Contact Lenses Loaded with Silicone Nanoparticles

Tran, Nguyen‐Phuong‐Dung; Yang, Ming‐Chien

doi:10.3390/polym12051128

Cited by 16 publications

(7 citation statements)

References 45 publications

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“…Figure 4 shows the FTIR spectra of HEMA, NVP, and poly(HEMA- co -NVP)-SNPs, where the peaks of C–H groups (2878 cm −1 ) and C=O groups (1720 cm −1 ) were observed. Additionally, in SNP-loaded lenses, the peaks of Si–O–Si group in SiO 2 were appeared at 720 and 1068 cm −1 while the C–N group of NVP were observed in 1150 cm −1 [ 6 , 15 ]. The characteristic peaks of C–C double bond were absent from the infrared spectrum of the resultant lens, indicating the successful synthesis of the hydrogel.…”

Section: Resultsmentioning

confidence: 99%

A Novel Approach to Increase the Oxygen Permeability of Soft Contact Lenses by Incorporating Silica Sol

et al. 2020

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This study presents a novel approach to increase the oxygen permeability of hydrogel by the addition of silica sol. Herein, 2-hydroxyethyl methacrylate (HEMA) was copolymerized with N-vinyl-2-pyrrolidone (NVP) after mixing with silica sol. The resultant hydrogel was subject to characterizations including Fourier-transform infrared (FTIR), equilibrium water content (EWC), contact angle, optical transmittance, oxygen permeability (Dk), tensile test, anti-deposition of proteins, and cytotoxicity. The results showed that with the increase of silica content, the Dk values and Young’s moduli increased, the optical transmittance decreased slightly, whereas the EWC and contact angle, and protein deposition were not much affected. Moreover, the cytotoxicity of the resultant poly(HEMA-co-NVP)-SNPs indicated that the presence of silica sol was non-toxic and caused no effect to the growth of L929 cells. Thus, this approach increased the Dk of soft contact lenses without affecting their hydrophilicity.

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Section: Resultsmentioning

confidence: 99%

A Novel Approach to Increase the Oxygen Permeability of Soft Contact Lenses by Incorporating Silica Sol

et al. 2020

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“…The oxygen permeability of the control and drug-laden contact lenses was determined at 100% relative humidity using a Cretech permeometer by Rehder Development Company (CA, USA). 39,40 The flat cell was stabilized and the intensity was measured with dark current to determine the oxygen permeability of the contact lens.…”

Section: Methodsmentioning

confidence: 99%

In vitro and in vivo evaluation of brimonidine loaded silica nanoparticles-laden silicone contact lenses to manage glaucoma

2022

J Biomater Appl

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Glaucoma is treated by frequent instillation of 0.2% w/v brimonidine tartrate eye drop solution, which showed poor ocular bioavailability of 1–3%. Medicated contact lenses can be used to improve the ocular drug bioavailability. However, drug loading in the contact lens matrix showed high burst release and changes the optophysical properties of the contact lens material. In this paper, a novel brimonidine loaded silica nanoparticles-laden silicone contact lenses (Bri-Si) were designed to achieve controlled drug delivery without altering the optophysical properties of the contact lens. Silica nanoparticles were prepared by polymerizing octadecyltrimethoxysilane (OTMS) molecules at the oil/water interface of microemulsion. Traditional soaking method (Bri-SM), direct brimonidine-loading method (Bri-DL) and microemulsion-laden contact lens (Bri-ME) were developed for comparison. The Bri-Si lens showed improved swelling, transmittance, oxygen permeability and lysozyme adherence compared to Bri-SM, Bri-DL and Bri-ME lenses. The Bri-DL lens showed high brimonidine leaching during extraction and sterilization steps, with low cumulative drug release. While, Bri-Si lens show controlled brimonidine release for 144 h. In a rabbit tear fluid model, the Bri-Si lens showed high brimonidine concentration for 96 h compared to Bri-ME lens and eye drop therapy. Based on histopathological studies of cornea, the Bri-Si lens was found to be safe for human applications. The data demonstrated the novel application of silica nanoparticles to control brimonidine release from the contact lens without altering the optophysical properties of the contact lens.

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“…In another study, Meola et al [13] used Capmul ® MCM in the preparation of silica-lipid hybrid microparticles to improve the dissolution and oral delivery of simvastatin. 2-hydroxyethyl methacrylate (HEMA) represents one of the most commonly used synthetic monomers for the preparation of crosslinked polymers and it has been widely used in many pharmaceutical applications such as soft contact lenses [14] and drug carriers [15]. The easiness of preparation, the flexibility in modifying the polymer structure, the ability to control the drug release and protect it from degradation as well as the polymer swelling behaviour are all features encouraged its use in many biomedical and drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

Bayan

2021

Int J App Pharm

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Objective: The main aim of this study was to design a drug carrier capable to control and enhance the release of poorly water soluble drugs. Methods: Three polymeric formulations, based on poly (2-hydroxyethyl methacrylate) and loaded with different Capmul® MCM C8 concentrations (0, 10 and 20 % w/w), were prepared. Felodipine, which is a poorly soluble substance, was selected as a model drug. The effect of Capmul® MCM C8 on swelling behavior and in vitro release profile of the prepared polymer was investigated in PBS. Results: The swelling profiles of allformulationswere statistically similar, which indicated the non-significant effect of added Capmul® MCM C8 on polymer's swelling behavior. All formulations showed a delayed drug release. Formulation-F3, which is loaded with 20% w/wCapmul® MCM C8 displayed a significant higher release compared to the other formulations. Conclusion: Capmul® MCM products, which are widely used in food industries, can be used to improve the oral delivery of poorly soluble substances. The optimized formulation exhibited the ability to control and enhance the release of the model drug.

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The Ophthalmic Performance of Hydrogel Contact Lenses Loaded with Silicone Nanoparticles

Cited by 16 publications

References 45 publications

A Novel Approach to Increase the Oxygen Permeability of Soft Contact Lenses by Incorporating Silica Sol

A Novel Approach to Increase the Oxygen Permeability of Soft Contact Lenses by Incorporating Silica Sol

In vitro and in vivo evaluation of brimonidine loaded silica nanoparticles-laden silicone contact lenses to manage glaucoma

Drug Release Control and Enhancement Using Carriers With Different Concentrations of Capmul® MCM C8

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