The Effects of Sevoflurane Anesthesia on Insulin Secretion and Glucose Metabolism in Pigs

Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentration-independent manner

“…The results of the present clinical study suggest that sevoflurane anesthesia impairs glucose tolerance in humans to the same degree as does isoflurane anesthesia. Previous studies have shown that levels of stress hormones, such as epinephrine, norepinephrine, and cortisol, which influence insulin output, are not increased during sevoflurane anesthesia [4]. Therefore, sevoflurane may directly inhibit insulin secretion.…”

“…In vitro, glucose-stimulated insulin secretion is inhibited by halothane in a concentrationdependent fashion [9]. Saho et al [4] have also reported that insulin secretion is inhibited by sevoflurane in a dose-dependent manner in pigs. However, this observed inhibition may have been due to their use of only the insulinogenic index as an index of insulin secretion, because zero-time insulin values differed among their various MAC groups.…”

“…Insulin secretion and glucose tolerance during sevoflurane anesthesia have been studied in pigs [4] and in humans during surgery [5]. In addition, studies in human subjects have shown that isofluranenitrous oxide anesthesia has dose-independent effects on insulin secretion [6].…”

Functional and histopathological study of the pancreas in hamsters (Mesocricetus auratus) infected and reinfected with Trypanosoma cruzi

“…Although inhalant anesthesia could influence the release of PI hormones in response to adrenergic stimulation and stress (Saho et al 1997), in this study infected and normal hamsters were equally submitted to inhalation of the same kind of anesthetic agent, allowing us to compare the data obtained from both groups of animals.…”

What is the optimal dose of glucose administration during minor surgery under sevoflurane anesthesia?

“…Nitrous oxide has been reported to change folic acid metabolism but not that of carbohydrates [16]. Saho et al suggested that sevoflurane and nitrous oxide anesthesia do not alter carbohydrate metabolism in comparison with combinations of nitrous oxide and other fluorocarbon anesthetics [17]. However, sevoflurane has been reported to lower insulin excretion in patients under prolonged anesthesia [18].…”