The Effects of Sevoflurane and Halothane Anesthesia on Cerebral Blood Flow Velocity in Children

“…Numerous articles report cardiac and cardiovascular complications subsequent to general anaesthesia with halothane [3,[6][7][8]. It may also have respiratory [4] and hepatic effects [5,11], being possibly associated with the development of fulminant hepatic failure [9].…”

Section: Anaesthesia Related Complicationsmentioning

confidence: 99%

“…Halothane is well known as an effective and usually safe anaesthetic agent, still in widespread use, being well tolerated by patients, without side effects in the upper airways and well suited for the inhalation induction of narcosis [1]. However, unwanted clinical problems may occasionally arise under halothane narcosis [3][4][5][6][7][8][9]. At the present time there is increased concern related to halothane narcosis for vulnerable groups, especially in children [3,4,[6][7][8] and through occupational exposure to this anaesthetic [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Selected Ion Monitoring – Gas Chromatography/Mass Spectrometry Determination of Halothane Fumes in Operating Theatres

Nicoarã

Culea

Nicac

et al. 2005

Indoor and Built Environment

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Halothane vapour, used as an inhaled anaesthetic for narcosis, is released during surgical operations causing occupational exposure to medical staff and nurses. The current work continues the controversial issues related to the biological side effects of halothane, and gives a simple method for sampling and determining the air concentration of the anaesthetic in different rooms used for surgical operations. Air contaminants were collected on active charcoal, using a portable pump. Liquid extraction with toluene was followed by injection of the eluate onto a GC capillary column coupled to a quadrupole mass detector. The method was validated with respect to linearity, precision and accuracy. The concentration of halothane in the air was found to depend on room volume, air ventilation rate inside the theatres, and on the technical condition of the vaporiser and anaesthesia devices. Introduction

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“…Monkhoff et al (2001) described a CBF increasing with a consequent increase in ICP, due to vasodilatation, variations in systemic arterial blood pressure and the loss of the cerebral vascular autoregulation. According to Omoigui (1998), the CBF increase is attenuated with time and reflects the restoration of cerebral vascular autoregulation.…”

Section: Introductionmentioning

confidence: 99%

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

Nunes

Leite²,

Paula³

et al. 2011

Arq. Bras. Med. Vet. Zootec.

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Intracranial variables in propofol or ABSTRACTThe effects of subarachnoid administration of iohexol on intracranial hemodynamic in dogs anesthetized with propofol or sevoflurane were evaluated. Thirty adult animals (10.92.9kg) were distributed into two groups: PG, where propofol was used for induction (100.5mg/kg), followed by a continuous rate infusion at 0.550.15mg/kg/hour, and SG, where sevoflurane was administered for induction (2.5 MAC) and for anesthetic maintenance (1.5 MAC). A fiberoptic catheter was implanted on the right superficial cerebral cortex to monitor intracranial pressure (ICP). After 30 minutes, cerebrospinal fluid (CSF) was collected at the cisterna magna and iohexol was injected. The measurements were performed before CSF collection (TA), after the iohexol injection (T0), and at 10-minute intervals (T10 to T60). Intracranial pressure decreased at T0 in SG. Cerebral perfusion pressure at T0 was higher than at TA, T50 and T60 in PG, but in SG, the mean value at T0 was higher than the ones from T20 to T60. Mean arterial pressure at T0 was higher than at TA in PG, while in SG, the values from T20 to T60 were lower than at T0. The heart rate at T60 was lower than at T0 in PG. Cardiac output at TA was lower than at T60 in SG. The cerebrospinal fluid collection and administration of iohexol promoted decrease in intracranial pressure in sevolflurane-anesthetized dogs and increase in cerebral perfusion pressure in propofol-anesthetized dogs.Keywords: anesthesia, dogs, cerebral autoregulation, myelography Palavras-chave: cão, anestesia, autoregulação cerebral, mielografia RESUMO Avaliaram-se os efeitos da administração subaracnóidea de iohexol sobre a hemodinâmica intracraniana em cães anestesiados com propofol ou sevofluorano. Trinta e dois animais (10,9±2,9kg) foram distribuídos em dois grupos: no GP, o propofol foi usado para indução, 100.5mg/kg, seguido por infusão contínua, 0,55±0,15mg/kg/min; no GS, o sevofluorano foi administrado para indução, 2,5 CAM, e manutenção, 1,5 CAM, da anestesia. O cateter de fibra óptica foi implantado na superfície direita do córtex cerebral para monitorar a pressão intracraniana (PIC). Após 30 minutos, o fluido cerebroespinhal (FCS) foi coletado da cisterna magna e o iohexol injetado. As mensurações ocorreram antes da coleta do FCS (TA), depois da injeção de iohexol (T0) e em intervalos de 10 minutos (T10 a T60

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The Effects of Sevoflurane and Halothane Anesthesia on Cerebral Blood Flow Velocity in Children

Cited by 24 publications

References 18 publications

Nasal encephalocele: Endoscopic excision with anesthetic consideration

Nasal encephalocele: Endoscopic excision with anesthetic consideration

Selected Ion Monitoring – Gas Chromatography/Mass Spectrometry Determination of Halothane Fumes in Operating Theatres

Intracranial variables in propofol or sevoflurane-anesthestized dogs subjected to subarachnoid administration of iohexol

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