“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Culture of mouse embryos has served as a tool for identifying these embryotoxins in human serum. I been suggested as a cause for reproductive failure because sera from some women with recurrent pregnancy 10SS,4,5,8,9,11.I3, 16 unexplained infertility,5,16 and infertility associated with endometriosis 14 inhibit growth of mouse embryos in vitro. Although the mouse blastocyst assay has been proposed to provide a basis for a new classification of idiopathic recurrent spontaneous abortion and act as an indicator of those women likely to respond to immunotherapy," the clinical utility of the embryotoxicity assay has been controversial.…”