The effects of salicylate on bacteria

Price, Christopher; Lee, Ian; Gustafson, John E.

doi:10.1016/s1357-2725(00)00042-x

Cited by 131 publications

(124 citation statements)

References 94 publications

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“…[31][32][33] Previous investigations identified a bacterial transcriptional response to salicylate treatment, which leads to the upregulation of multiple drug resistance systems and induces appreciable phenotypic changes. 34 In the current study, Vila et al observed an inverse relationship between biofilm formation and salicylate, such that sessility is no longer favored at high salicylate concentrations. 30 In an attempt to identify differentially expressed factors in the presence of high salicylate levels that may contribute to the observed reduction in biofilm, the authors performed proteome profiling using 2D-gel electrophoresis.…”

supporting

confidence: 43%

What does it take to stick around?

Hadjifrangiskou

Hultgren²

2012

Virulence

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supporting

confidence: 43%

What does it take to stick around?

Hadjifrangiskou

Hultgren²

2012

Virulence

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“…Paradoxically, it can also reduce resistance to some antibiotics (Price et al, 2000). E. coli, for example exhibits increased resistance to chloramphenicol, ampicillin, naldixic acid and tetracycline after such treatment.…”

Section: B Non-antimicrobial Agentsmentioning

confidence: 99%

Application of Scanning Electron Microscopy for the Morphological Study of Biofilm in Medical Devices

El-Baky¹

2012

Scanning Electron Microscopy

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“…However, salicylate has been shown to decrease the susceptibility of bacteria, such as E. coli, to antimicrobials by altering membrane proteins and inducing efflux pumps (Price et al, 2000). Since C. jejuni possesses an outer-membrane protein (MOMP) belonging to the same porin family as E. coli OmpF (Bolla et al, 1995) and a multidrug efflux pump (CmeABC) belonging to the same RND family as AcrAB-TolC (Lin et al, 2002), it has been speculated that salicylate might also decrease antimicrobial accumulation in C. jejuni.…”

Section: Effect Of Sodium Salicylatementioning

confidence: 99%

“…This causes the down-regulation of the outermembrane protein OmpF and an increase in the synthesis of the RND multidrug efflux pump AcrAB-TolC, which leads to decreased antimicrobial accumulation (Price et al, 2000). Salicylate has also been reported to increase the effect of antimicrobial aminoglycosides in E. coli (Aumercier et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli

Hannula

Hänninen

2008

Journal of Medical Microbiology

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The CmeABC efflux pump plays an important role in the antimicrobial resistance of Campylobacter jejuni and Campylobacter coli. The aim of this investigation was to study the effect of putative efflux pump inhibitors, phenyl-arginine-b-naphthylamide (PAbN) and 1-(1-naphthylmethyl)-piperazine (NMP), as well as the effect of putative efflux pump inducers, sodium salicylate and sodium deoxycholate, on the MIC levels of erythromycin, ciprofloxacin, kanamycin, tetracycline and rifampicin for C. jejuni and C. coli. Our results indicated that susceptibility to erythromycin and rifampicin increased, respectively, 8-to 32-and 8-to 64-fold in the presence of PAbN and to a lesser extent in the presence of NMP. Salicylate produced a 2-to 4-fold increase in ciprofloxacin MIC values, whereas little effect was observed in the presence of deoxycholate. INTRODUCTIONCampylobacteriosis is the leading cause of bacterial gastroenteritis in industrialized countries (Friedman et al., 2000). Although in most cases the illness is self-limiting, in severe cases and in immunocompromised patients, the use of antimicrobial agents is warranted. However, the rapid increase in resistant strains and the emergence of strains with multiple resistances are of growing concern (Ruiz et al., 2007).It has been established that efflux pumps, particularly the resistance-nodulation-cell division (RND) type CmeABC pump, have an important role in the antimicrobial resistance of Campylobacter jejuni (Lin et al., 2002). The same efflux pump has recently been characterized in Campylobacter coli (Corcoran et al., 2005). This pump is able to significantly decrease the susceptibility of Campylobacter to a number of antimicrobials (Lin et al., 2002).Efforts have been made to find substances capable of reversing the action of the efflux pumps and which therefore have the potential to prevent antimicrobial resistance in vivo. A broad-spectrum efflux pump inhibitor (EPI), phenyl-arginine-b-naphthylamide (PAbN), was first characterized in Pseudomonas aeruginosa (Lomovskaya et al., 2001) and has since been studied in several bacteria, including Campylobacter (Cagliero et al., 2005;Gibreel et al., 2007;Payot et al., 2004). Another putative EPI is 1-(1-naphthylmethyl)-piperazine (NMP), characterized in Escherichia coli (Bohnert & Kern, 2005). It is able to partially reverse multidrug resistance in some members of the Enterobacteriaceae and in Acinetobacter baumannii (Bohnert & Kern, 2005;Pannek et al., 2006; Schumacher et al., 2006) but its effects on Campylobacter have not been studied previously.In E. coli, salicylic acid binds to a repressor protein, MarR, which results in the overexpression of the global regulatory gene marA. This causes the down-regulation of the outermembrane protein OmpF and an increase in the synthesis of the RND multidrug efflux pump AcrAB-TolC, which leads to decreased antimicrobial accumulation (Price et al., 2000). Salicylate has also been reported to increase the effect of antimicrobial aminoglycosides in E. coli (Aumercier et al., 1990). ...

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The effects of salicylate on bacteria

Cited by 131 publications

References 94 publications

What does it take to stick around?

What does it take to stick around?

Application of Scanning Electron Microscopy for the Morphological Study of Biofilm in Medical Devices

Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli

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