The effects of resveratrol on tendon healing of diabetic rats

Zeytin, Kayhan; Çiloğlu, Nesibe Sinem; Ateş, Filiz; Aker, Fügen; Ercan, Feríha

doi:10.3944/aott.2014.13.0096

Cited by 12 publications

(13 citation statements)

References 27 publications

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“…Previous studies reported that various antioxidants are effective for treating musculoskeletal tissue degeneration . Kim et al showed that oxidative stress induces autophagic cell death in rotator cuff tenofibroblasts, and cyanidin inhibits cell death.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that various antioxidants are effective for treating musculoskeletal tissue degeneration. 20,31,[43][44][45][46] Kim et al 44 showed that oxidative stress induces autophagic cell death in rotator cuff tenofibroblasts, and cyanidin inhibits cell death. Morikawa et al 20 revealed that rotator cuff degeneration in SOD1 deficient-mice could be suppressed by vitamin C. Moreover, Koike et al 31 reported that vitamin C effectively suppressed superoxide generation and cartilage degeneration.…”

Section: Discussionmentioning

confidence: 99%

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Association of Superoxide‐Induced Oxidative Stress With Rotator Cuff Tears in Human Patients

Yoshida

Itoigawa

Wada

et al. 2019

Journal Orthopaedic Research

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Rotator cuff degeneration is one of the factors contributing to rotator cuff tears. Oxidative stress is involved in tendon degeneration, and superoxide‐induced oxidative stress plays a pathological role in regulating the balance between oxidation and reduction. The role of oxidative stress in rotator cuff tears, however, is unclear. This study, therefore, aimed to investigate the contribution of superoxide‐induced oxidative stress to rotator cuff tears. Seventy patients were recruited and divided into two groups: patients with (Ruptured group) and those without (Unruptured group) a rotator cuff tear. Specimens from both groups were collected during surgery. Degeneration morphology was classified according to the degeneration score. Superoxide‐induced oxidative stress was assessed according to dihydroethidium (DHE) relative fluorescence intensity, capacity for antioxidation according to superoxide dismutase (SOD) activity, and the balance between oxidation and reduction based on the redox ratio. Data were compared between groups. Correlations between the degeneration score and the oxidative stress factors were calculated. Degeneration score and DHE relative fluorescence intensity were significantly higher in the Ruptured than the Unruptured group. The SOD activity was not significantly different between groups. Degeneration score was positively correlated with both DHE relative fluorescence intensity and SOD activity. Thus, superoxide‐induced oxidative stress and tendon degeneration were greater in rotator cuff tear tissues than in those with no tear, suggesting that oxidative imbalance may be involved in degenerative rotator cuff tears. Clinical Relevance: Understanding the mechanisms of superoxide‐induced oxidative stress may lead to targeted tissue therapy for degenerative rotator cuff tears. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:212–218, 2020

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of Superoxide‐Induced Oxidative Stress With Rotator Cuff Tears in Human Patients

Yoshida

Itoigawa

Wada

et al. 2019

Journal Orthopaedic Research

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“…STZ-induced rats were maintained for another 2 weeks before renal I/R. To examine the effect of RES, 10 mg/kg RES (Sigma-Aldrich, St. Louis, MO, USA) was intraperitoneally injected daily for 7 consecutive days before renal I/R [37]. The diabetic and normal rats were randomly divided into six groups of 4–6 rats each: ND sham group (NS); ND I/R group (NI/R); DM sham group (DS); DM + RES sham group (DS-RES); DM I/R group (DI/R); and DM + RES I/R group (DI/R-RES).…”

Section: Methodsmentioning

confidence: 99%

Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

Xiao

Huang

Wang

et al. 2016

Oxidative Medicine and Cellular Longevity

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Kidney in diabetic state is more sensitive to ischemic acute kidney injury (AKI). However, the underlying mechanisms remain unclear. Herein, we examined the impact of diabetes mellitus on thioredoxin-interacting protein (TXNIP) expression and whether mediated NLRP3 activation was associated with renal ischemia/reperfusion- (I/R-) induced AKI. In an in vivo model, streptozotocin-induced diabetic rats showed higher susceptibility to I/R injury with increased TXNIP expression, which was significantly attenuated by resveratrol (RES) treatment (10 mg/kg intraperitoneal daily injection for 7 consecutive days prior to I/R induction). RES treatment significantly inhibited TXNIP binding to NLRP3 in diabetic rats subjected to renal I/R injury. Furthermore, RES treatment significantly reduced cleaved caspase-1 expression and production of IL-1β and IL-18. In an in vitro study using cultured human kidney proximal tubular cell (HK-2 cells) in high glucose condition (HG, 30 mM) subjected to hypoxia/reoxygenation (H/R), HG combined H/R (HH/R) stimulated TXNIP expression which was accompanied by increased NLRP3 expression, ROS generation, caspase-1 activity and IL-1β levels, and aggravated HK-2 cells apoptosis. All these changes were significantly attenuated by TXNIP RNAi and RES treatment. In conclusion, our results demonstrate that TXNIP-mediated NLRP3 activation through oxidative stress is a key signaling mechanism in the susceptibility to AKI in diabetic models.

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“…It has diverse biological activities including anti-oxidation [21] , anti-cancer [22] , anti-inflammation [23] , cardioprotection [24] , and neuroprotection [25] . Several reports indicate that RSV is capable of preventing and treating diabetes and its related complications [26,27] . However, the effect of RSV on diabetic periodontitis and the underlying mechanisms of action are not clear.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling

et al. 2014

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Aim: To investigate the therapeutic effects of resveratrol (RSV) on periodontitis in diabetic mice and to explore the underlying mechanisms in vitro. Methods: Experimental periodontitis was induced in db/db mice by ligature application of porphyromonas gingivalis. The mice were treated with RSV (20 mg/kg, po) daily for 4 weeks. Alveolar bone loss, proinflammatory cytokines and TLR4 expression in the gingival tissue were measured. Cultured gingival epithelial cells (GECs) were used for in vitro studies. The transcriptional activity of TLR4 downstream signaling was analyzed using Western blotting. Results: RSV administration significantly decreased the blood glucose levels, and ameliorated alveolar bone loss in db/db mice with experimental periodontitis. RSV administration also suppressed the high levels of IL-1β, IL-6, IL-8, TNF-α, and TLR4 in gingival tissue of the mice. In the GECs incubated in high glucose medium, TLR4 expression was substantially upregulated, which was partly blocked in the presence of RSV. Lipopolysaccharides markedly increased the expression and secretion of IL-1β, IL-6, IL-8, and TNF-α in the GECs cultured in high glucose medium, which was also partly blocked in the presence of RSV. Furthermore, RSV significantly suppressed the phosphorylation of TLR4 downstream factors NF-κB p65, p38MAPK, and STAT3. Conclusion: RSV exerts protective effects against experimental periodontitis in db/db mice via negative regulation of TLR4 signaling.

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The effects of resveratrol on tendon healing of diabetic rats

Abstract: Resveratrol appears to have a positive impact on the process of tendon healing in diabetic conditions in the first 14 days.

Cited by 12 publications

References 27 publications

Association of Superoxide‐Induced Oxidative Stress With Rotator Cuff Tears in Human Patients

Association of Superoxide‐Induced Oxidative Stress With Rotator Cuff Tears in Human Patients

Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes

Resveratrol ameliorates experimental periodontitis in diabetic mice through negative regulation of TLR4 signaling

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