1953
DOI: 10.1172/jci102733
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The Effects of Quiet Standing on Solute Diuresis 1

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1954
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Cited by 19 publications
(15 citation statements)
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“…The rate of renal excretion of sodium appears to be directly proportional, under the conditions of these experiments, to the rate of excretion of the mannitol, which in turn is directly proportional to the filtered load of mannitol (22). However, it will be noted that the slopes and intercepts of the lines relating mannitol and sodium excretion ( Figure 2) are not identical in the three subjects, indicating that other factors than the mannitol excretion rate are active in regulating sodium excretion, as has been observed previously (11,12). Mannitol, as a non-electrolyte which probably does not cross cell membranes in significant amounts, would be expected to affect the equilibria of diffusible electrolytes as well as water across the cell membranes which are in contact with the mannitol.…”
Section: Resultsmentioning
confidence: 61%
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“…The rate of renal excretion of sodium appears to be directly proportional, under the conditions of these experiments, to the rate of excretion of the mannitol, which in turn is directly proportional to the filtered load of mannitol (22). However, it will be noted that the slopes and intercepts of the lines relating mannitol and sodium excretion ( Figure 2) are not identical in the three subjects, indicating that other factors than the mannitol excretion rate are active in regulating sodium excretion, as has been observed previously (11,12). Mannitol, as a non-electrolyte which probably does not cross cell membranes in significant amounts, would be expected to affect the equilibria of diffusible electrolytes as well as water across the cell membranes which are in contact with the mannitol.…”
Section: Resultsmentioning
confidence: 61%
“…Goodyer and Seldin ( 11 ) gave hypertonic mannitol solutions to two subjects during quiet standing and found less increase in salt excretion than normally occurs; to one standing, hydrated subject they gave a small amount (one liter) of hypotonic mannitol and found no increase in salt excretion.2 Recently it has also been shown that dogs on a low salt intake prior to mannitol infusion exhibit far less natriuresis than those on a high salt intake (12). These findings suggest that other factors which affect the renal reabsorption of sodium may affect sodium excretion during mannitol diuresis.…”
mentioning
confidence: 99%
“…In a previous communication (4) the literature has been summarized to indicate that a) most workers find a fall in filtration rate on changing from the horizontal to a head-up tilt or to standing, b) all workers find falls in water and sodium excretion on changing from the horizontal to a head-up tilt or to standing. Additional relevant reports have since been published (5,(18)(19)(20).…”
Section: Discussionmentioning
confidence: 99%
“…The consequent retention of sodium is not accompanied by an increase in the rates of excretion of potassium and ammonium when quiet standing is superimposed upon a diuresis induced by water ingestion (16,17), infusion of physiological saline (4, 17), (4). The fact that urinary out-tion which postulate an inverse relationship between puts of potassium, ammonium and hydrogen ions the rates of secretion of potassium and hydrogen were simultaneously increased when sodium reten-ions (19), it is of interest that increases in the tion was provoked during the infusion of a non-production of ammonium and marked falls in urireabsorbable anion suggests alterations in tubular nary pH were promoted acutely by quiet standing activity since this cannot be explained by the hy-with a simultaneous increase in the excretion of pothesis of a lowered rate of glomerular filtration potassium.…”
Section: Discussionmentioning
confidence: 99%