1955
DOI: 10.1172/jci103108
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Mechanism of Increased Renal Sodium Excretion Following Mannitol Infusion in Man

Abstract: Mannitol, when given intravenously to normal human subjects or animals, shares with a number of other substances the property of promoting an increased rate of renal excretion of sodium, chloride, and water. The generally accepted hypothesis concerning the mechanism of this action is that mannitol exerts its effect directly on the renal tubules. The osmotic pressure of the mannitol within the tubular lumen is considered to interfere with the reabsorption of water. Sodium excretion is thought to be increased in… Show more

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Cited by 21 publications
(6 citation statements)
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References 16 publications
(26 reference statements)
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“…These effects qualitatively and quantitatively resemble those produced by aminophylline in normal subjects (48) and by mannitol in both normal (51) and cirrhotic subjects (52). Since, as stated previously, these effects occurred without much change in CNa/CIn, the major action of norepinephrine in cirrhosis appears to be an increase in the GFR, leading to delivery of more of the filtrate to the distal nephron.…”
Section: Discussionsupporting
confidence: 76%
“…These effects qualitatively and quantitatively resemble those produced by aminophylline in normal subjects (48) and by mannitol in both normal (51) and cirrhotic subjects (52). Since, as stated previously, these effects occurred without much change in CNa/CIn, the major action of norepinephrine in cirrhosis appears to be an increase in the GFR, leading to delivery of more of the filtrate to the distal nephron.…”
Section: Discussionsupporting
confidence: 76%
“…An increase in endogenous ADH activity as serum osmolality rose may have produced the precipitous falls in CFH9O shown in Table VII. Williams and associates (25) also noted an increase in CFH2O with the infusion of 5 per cent mannitol in one of three studies in orally hydrated subjects. It is worthy of note that the serum osmolality of the subject demonstrating the increase in CFH2O fell from 271 to 267 mOsm per L during the infusion of the mannitol.…”
Section: Fig 2 Osmolal Clearance (Hatched Areas Below) Free Water mentioning
confidence: 86%
“…Mannitol also does not interact with any known receptors and has an extremely low permeability across biologic membranes (29). Mannitol has long been used as a diuretic and as a marker to test renal function (30). It is also used as a non-absorbable marker for intestinal drug absorption studies.…”
Section: Discussionmentioning
confidence: 99%